Studies of the interaction of 5‐hydroxytryptamine and the perivascular innervation of the guinea‐pig caecum

Drakontides, Anna B.; Gershon, Michael D.

doi:10.1111/j.1476-5381.1972.tb08098.x

Cited by 27 publications

(2 citation statements)

References 30 publications

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“…This has also been found in 3-day post-natal rabbits (Day & Rand, 1961;Burn, 1968 (Burnstock, 1969). The cholinergic component of the perivascular innervation is masked in adult mammals and is not seen unless adrenergic fibres are paralysed with a drug such as reserpine (Gillespie & MacKenna, 1961) or destroyed by treatment with 6-hydroxydopamine (Drakontides & Gershon, 1972). In foetal and new-born gut, therefore, the extrinsic adrenergic innervation is not yet functionally developed and the cholinergic innervation must function without adrenergic modulation.…”

Section: Discussionmentioning

confidence: 99%

The maturation of neuromuscular function in a multiply innervated structure: development of the longitudinal smooth muscle of the foetal mammalian gut and its cholinergic excitatory, adrenergic inhibitory, and non‐adrenergic inhibitory innervation

Gershon¹,

Thompson²

1973

The Journal of Physiology

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SUMMARY1. The earliest components of the developing innervation of the rabbit intestine to be detected in this study were the cholinergic excitatory and the intrinsic inhibitory innervation. These developed simultaneously in the rabbit at 17 days of gestation. Both were also present in the mouse by the 16th day of gestation. Responsiveness of rabbit tissue to exogenous acetylcholine appeared together with the advent of a functional cholinergic innervation. Since excitatory responses were potentiated by eserine, the tissue was probably able to inactivate acetylcholine through hydrolysis mediated by cholinesterase. Early relaxant responses resisted blockade by adrenergic neurone blocking agents and by antagonists active at a-and /J-adrenoceptors.2. The development of the adrenergic innervation lagged far behind that of the other two components. Specific uptake of noradrenaline in the rabbit was detected for the first time at the 21st day of gestation and stores of noradrenaline could not be detected histochemically until 26-28 days. However, relaxant responses to stimulation of the perivascular sympathetic supply, such as characterize adult tissues, had not yet developed by the time of birth. Relaxation in response to perivascular stimulation could be seen 30 days after birth.3. Morphologic studies indicated that the longitudinal layer of smooth muscle was very primitive when an effective innervation was established.

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Section: Discussionmentioning

confidence: 99%

The maturation of neuromuscular function in a multiply innervated structure: development of the longitudinal smooth muscle of the foetal mammalian gut and its cholinergic excitatory, adrenergic inhibitory, and non‐adrenergic inhibitory innervation

Gershon¹,

Thompson²

1973

The Journal of Physiology

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“…Tachyphylaxis (TPX) to 5HT is a normal phenomenon detected in the isolated organs of animals of various species (1,2,3,4,5,6,7), as well as in the rings of the human temporal artery in vitro (8). The fatigue of smooth muscle which follows its repeated exposure to 5HT is attributed to an indirect effect this monoamine has upon the presynaptic sympathetic neuron, resulting in nor-adrenaline (NA) release into the synaptic cleft.…”

Section: Introductionmentioning

confidence: 99%

Is Acute Tolerance to 5-Hydroxytryptamine Opioid Dependent? Its Absence in Migraine Sufferers

Sicuteri

1983

Cephalalgia

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The human dorsal hand vein, exhausted in vivo (tachyphylaxis) by repeated inoculations of 5-hydroxytryptamine, recovers its capacity to contract in response to the 5HT when naloxone (per se ineffective) is inoculated into the same vein. It would seem, therefore, that in the 5HT tachyphylactic mechanism a role could be played by the progressive excitation of a local opioid modulator apparatus (silent in basal condition); naloxone's capacity for neutralizing the vein's fatigue could be indirect evidence of this. This postulation of an opioid role in the tachyphylactic mechanism differs from the conventional thesis, which explains tachyphylaxis as a progressive exhaustion of NA released from the sympathetic neuron by 5HT (see Table 1). Tachyphylaxis is poor, delayed or absent in migraine sufferers; this anomaly is present even in the period between attacks. The anomaly of inverted tachyphylaxis appears amplified during attacks. The loss or inversion of 5HT-tachyphylaxis is constantly observed in heroin addicts during acute abstinence. The fact that the clinical phenomena of acute heroin abstinence are comparable with those of a migraine attack could be a matter for further investigation.

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Lower extremity vasospasm associated with ischemic neuropathy, dermal fibrosis, and digital gangrene in a patient with carcinoid syndrome

Küçük¹,

Noskin²,

Petersen³

et al. 1988

Cancer

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Bilateral lower extremity vasospasm associated with severe pain and hyperesthesias in the legs, and digital gangrene in both feet developed in a 50-year-old man with carcinoid syndrome. Nifedipine and chemical lumbar sympathectomy were partially effective in relieving the vasospasm. Electromyographic findings were consistent with ischemic neuropathy. A skin biopsy specimen showed striking dermal fibrosis. Serotonin and other vasoconstrictor substances released from the tumor may be responsible for the vasospasm, the dermal sclerosis, and the ischemic neuropathy. The early use of lumbar sympathec-tomy in patients with lower extremity vasospasm may prevent these irreversible ischemic complications. Cancer 62:1026-1029, 1988. ARCINOID TUMORS are apudomas' originating C from the Kulchitsky cells of the crypts of Lieber-kuhn.' Pearse coined the term APUD for cells with amine precursor uptake and decarb~xylation.~ These endocrine cells are widely distributed in the body and are particularly numerous in the gastrointestinal tract. They synthesize and secrete several biologically active peptides and amines including serotonin, substance P, histamine, prostaglandins, kallikrein, bradykinin, Shy-droxytryptophan, hydroxytryptophol, vasoactive intestinal polypeptide (VIP), catecholamines, calcitonin, corticotropin (ACTH), and growth h ~ r m o n e. " ~ Carcinoid syndrome usually occurs when the hepatic inactivation of the amine is exceeded because of the massive secretion by the primary tumor, or if the tumor involves the liver, which reduces the metabolizing capacity and also permits a direct release of secretory products into the hepatic veins. The systemic manifestations of the syndrome are ~ariable.~ The most frequent symptoms include diarrhea, flushing, those due to valvular disease of the right heart, and asthma.6 More unusual are the manifestations of malnutrition and pellagra due to overconsumption of tryptophan by the tumor.7 From the Divisions of Hematology/Oncology and Vascular Surgery,

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Studies of the interaction of 5‐hydroxytryptamine and the perivascular innervation of the guinea‐pig caecum

Cited by 27 publications

References 30 publications

The maturation of neuromuscular function in a multiply innervated structure: development of the longitudinal smooth muscle of the foetal mammalian gut and its cholinergic excitatory, adrenergic inhibitory, and non‐adrenergic inhibitory innervation

The maturation of neuromuscular function in a multiply innervated structure: development of the longitudinal smooth muscle of the foetal mammalian gut and its cholinergic excitatory, adrenergic inhibitory, and non‐adrenergic inhibitory innervation

Is Acute Tolerance to 5-Hydroxytryptamine Opioid Dependent? Its Absence in Migraine Sufferers

Lower extremity vasospasm associated with ischemic neuropathy, dermal fibrosis, and digital gangrene in a patient with carcinoid syndrome

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