Studies of the mechanism by which the mechanical failure of polymethylmethacrylate leads to bone resorption.

Horowitz, Stephen M.; Doty, Stephen B.; Lane, Joseph M.; Burstein, Albert H.

doi:10.2106/00004623-199306000-00002

Cited by 280 publications

(167 citation statements)

References 26 publications

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“…[1][2][3] Prostaglandins, cytokines, metalloproteinases, lysosomal enzymes and other substances are produced by the interface tissue, but their relative importance in the resorption of periprosthetic bone is controversial [4][5][6][7][8][9][10][11][12][13][14][15][16] An understanding of the cellular and cytokine profiles of tissues surrounding revised joint prostheses may further elucidate the biological processes of loosening and osteolysis and suggest preventative or therapeutic methods which may favourably affect the survival of the implant. Our aim in this prospective study was to determine the major cell types and cytokines produced by periprosthetic tissues, using immunohistochemistry and in situ hybridisation.…”

mentioning

confidence: 99%

Cellular profile and cytokine production at prosthetic interfaces

Goodman¹,

Huie

Song³

et al. 1998

The Journal of Bone and Joint Surgery. British volume

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T he tissues surrounding 65 cemented and 36 cementless total joint replacements undergoing revision were characterised for cell types by immunohistochemistry and for cytokine expression by in situ hybridisation.We identified three distinct groups of revised implants: loose implants with ballooning radiological osteolysis, loose implants without osteolysis, and well-fixed implants. In the cemented series, osteolysis was associated with increased numbers of macrophages (

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mentioning

confidence: 99%

Cellular profile and cytokine production at prosthetic interfaces

Goodman¹,

Huie

Song³

et al. 1998

The Journal of Bone and Joint Surgery. British volume

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“…We used the mouse cell line J774.A1 because of the close resemblance to macrophages seen in the proximity of prosthesis and cement in humans (Bockman, 1981;Catelas et al, 1999;Horowitz et al, 1993). Non-stimulated J774A.1 cells tend to be less activated and thereby create a more uniform inflammatory response, when delicate changes are studied, than isolated human monocytes/ macrophages.…”

Section: Discussionmentioning

confidence: 99%

“…Authors: The authors agree that one has to be careful before extrapolating these results into a human clinical setting. We used the murine J774A.1 cell line because it is reported to create a more uniform inflammatory response when studying delicate changes, than harvested isolated human monocytes/macrophages (Horowitz et al, 1993;Sethi et al, 2003; text references). The J774A.1 cell line have demonstrated several effects [patterns] comparable to that of human macrophages, e.g.…”

Section: Jhuntmentioning

confidence: 99%

“…The J774A.1 cell line have demonstrated several effects [patterns] comparable to that of human macrophages, e.g. phagocytosis, transcription and release of proinflammatory cytokines when activated, transcription and release of TGF-β, transcription of BMP-2 at rest (nonactivated), and finally the ability to speed out on a surface [Bockman, 1981;Catelas et al, 1999;Horowitz et al, 1993 (all text references); Takebe et al, 2007]. In agreement with these reports, we have in the present study and other current studies observed the same basic features in our J774A.1 cell line -e.g.…”

Section: Jhuntmentioning

confidence: 99%

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Effects of AS-cast and wrought cobalt-chrome-molybdenum and titanium-aluminium-vanadium alloys on cytokine gene expression and protein secretion in J774A.1 macrophages

Jakobsen

Stoltenberg²,

Bruun³

et al. 2007

eCM

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Insertion of metal implants is associated with a possible change in the delicate balance between pro-and antiinflammatory proteins, probably leading to an unfavourable predominantly pro-inflammatory milieu. The most likely cause is an inappropriate activation of macrophages in close relation to the metal implant and wear-products. The aim of the present study was to compare surfaces of as-cast and wrought Cobalt-Chrome-Molybdenum ( . Lactate dehydrogenase (LDH) was measured in the medium to asses the cell viability. Surface properties of the discs were characterised with a profilometer and with energy dispersive X-ray spectroscopy. We here report, for the first time, that the prosthetic material surface (nonphagocytable) of as-cast high carbon CoCrMo reduces the pro-inflammatory cytokine IL-6 transcription, the chemokine MCP-1 secretion, and M-CSF secretion by 77 %, 36 %, and 62 %, respectively. Furthermore, we found that reducing surface roughness did not affect this reduction. The results suggest that as-cast CoCrMo alloy is more inert than wrought CoCrMo and wrought TiAlV alloys and could prove to be a superior implant material generating less inflammation which might result in less osteolysis.

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“…To avoid wear, design features including modularity, geometry and implant fixation have been shown to be among the most important variables relating to the generation of wear particles. 7,16 The femoral head size has been shown to be an important factor affecting wear. Volumetric wear of polyethylene increases with increasing the head diameter.…”

Section: Preventionmentioning

confidence: 99%

Review Article: Polyethylene Wear and Osteolysis in Total Hip Arthroplasty

Zhu

Chiu

Tang

2001

J Orthop Surg (Hong Kong)

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Polyethylene wear has been accepted as a major cause of osteolysis in total hip arthroplasty. Submicron particles, which are secondary to abrasive wear, migrate into the effective joint space and stimulate a foreign-body response resulting in bone loss which is mainly mediated by macrophages. Diagnosis depends on serial radiographic evaluation and frequent followup. Polyethylene wear and osteolysis can be prevented by reducing the wear such as using a small femoral head, adaptive polyethylene thickness, suitable surgical techniques, non-polyethylene articulation, etc. The presence of cement or circumferential coatings may also retard the distal migration of particles. Medicines such as NSAIDs and bisphosphonate appear to inhibit the progress of osteolysis. As far as treatment, revision surgery is able to reconstruct the joint by replacing partial or total prosthesis and repair the defect by bone grafting according to intraoperative assessment.

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Studies of the mechanism by which the mechanical failure of polymethylmethacrylate leads to bone resorption.

Cited by 280 publications

References 26 publications

Cellular profile and cytokine production at prosthetic interfaces

Cellular profile and cytokine production at prosthetic interfaces

Effects of AS-cast and wrought cobalt-chrome-molybdenum and titanium-aluminium-vanadium alloys on cytokine gene expression and protein secretion in J774A.1 macrophages

Review Article: Polyethylene Wear and Osteolysis in Total Hip Arthroplasty

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