Studies of the Oxygen Consumption of Fresh Placental Tissue From Normal and Abnormal Pregnancies

Mackay, Rachel B.

doi:10.1111/j.1471-0528.1958.tb08874.x

Cited by 23 publications

(6 citation statements)

References 8 publications

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“…Measurements of 02 consumption of tissue slices or homogenates from the placentas of man, rabbit, rat, mouse and guinea-pig were made under varying conditions by Murphy & Hawkins (1925), Fujita (1928), Blair Bell, Brook & Jowett (1928, Adler (1930), Loeser (1932), Wang & Hellman (1943), Thompson & Tickner (1949), Hellman, Harris & Andrews (1950, Villee (1953), Kyank (1954), Domany, Csaba & Szekely (1956), Nyberg & Westin (1957), McKay (1958), and Friedman & Sachtleben (1960. The 02 consumption ranged from 1-3 to 75 5,l./mg dry wt.…”

Section: Discussionmentioning

confidence: 99%

The oxygen consumption of the placenta and foetal membranes in the sheep

Campbell¹,

Dawes²,

Fishman³

et al. 1966

The Journal of Physiology

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SUMMARY1. In anaesthetized sheep near term the 02 uptake of the foetus from the placenta was reduced to zero either by replacing the foetus with a mechanical pump, or by ventilation of the foetus after delivery or in utero. When umbilical arterial and venous Po. were made equal, they were much less than maternal arterial Po2.2. This difference in Po2 was attributed to 02 consumption both within the placental cotyledons and the extra-cotyledonary foetal membranes. 3. The foetal membranes and cord in the sheep are supplied by branches of umbilical blood vessels and constitute an oxygen-consuming by-pass on the foetal side of the placenta.4. The 02 consumption of individual placental cotyledons was measured in vivo.5. The combined 02 consumption of the whole placenta and foetal membranes in vivo was a considerable fraction of foetal 02 consumption.6. The consequences of these observations are discussed in relation to 02 transfer across the placenta.

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Section: Discussionmentioning

confidence: 99%

The oxygen consumption of the placenta and foetal membranes in the sheep

Campbell¹,

Dawes²,

Fishman³

et al. 1966

The Journal of Physiology

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“…I ersichtlich, ist der Sauerstofiverbrauch der Mito chondrien von Plazenten der ersten Schwangerschaftshälfte m it Isozi tra t als Substrat ungefähr doppelt so groß, wie der von Mitochondrien aus Term inplazenten. Es stim m t dies mit den Ergebnissen von Villee [9], M cKay [6] Zusammenfassend läßt sich somit sagen, daß das in den plazentaren Mitochondrien vorhandene Progesteron sehr wahrscheinlich der Akti vator der dort vorhandenen latenten ATP'ase ist. Infolge der durch ATP'ase freigesetzten biologisch nutzbaren Energie, ist Progesteron som it indirekt maßgebend an der Stoffwechsel-und Transportkapazi tät der Plazenta beteiligt.…”

Section: Methodikunclassified

Untersuchungen an Mitochondrien der Plazenta beim Menschen

Schreiner¹,

Villee²

1965

Gynecol Obstet Invest

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“…Placental oxygen consumption as measured in vivo in the rabbit and sheep is approximately 10.7 and 10.4 mi/min per kg (Campbell et aI., 1966;Faber and Hart, 1966), respectively. Estimates of Oz consumption for human placenta derived from in vitro studies of placental slices (Friedman and Sachtleben, 1960;Mackay, 1958;Villee, 1953b) and from perfusion of the umbilical circulation (Nyberg and Westin, 1957) were 3-4 ml/min per kg, a figure that appears to be far too low. Recent investigations in which the maternal intervillous space was perfused with blood yielded estimates of 10 mi/min per kg (Challier et aI., 1976).…”

Section: Oxygen Transfermentioning

confidence: 96%

Human Growth

1986

107

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Studies of the Oxygen Consumption of Fresh Placental Tissue From Normal and Abnormal Pregnancies

Cited by 23 publications

References 8 publications

The oxygen consumption of the placenta and foetal membranes in the sheep

The oxygen consumption of the placenta and foetal membranes in the sheep

Untersuchungen an Mitochondrien der Plazenta beim Menschen

Human Growth

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