Studies of Thyrotropin Physiology by Means of Radioimmunoassay

Odell, William D.; Wilber, John F.; Utiger, Robert D.

doi:10.1016/b978-1-4831-9826-2.50005-2

Cited by 205 publications

(92 citation statements)

References 46 publications

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“…1). As has been reported in the adult [15,30], TSH levels in children were remarkably constant throughout the day; when serial determinations were performed at 4-hr intervals in three of the children, no changes greater than 0.5 ng/ml were encountered. No abrupt rise in TSH values paralleling those of HGH were observed when serum samples were obtained in four children 2 hr after initiation of sleep.…”

Section: Normal Subjectsmentioning

confidence: 65%

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Thyrotropin Behavior in Thyroid Disorders of Childhood

1973

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Through the use of a double antibody radioimmunoassay method, the mean serum concentration of thyrotropin (TSH) in 51 normal children aged 1 month-18 years was 3.7 ng/ml. There was no change with age, sex, or time of the day at which the sample was obtained.In six of nine newly diagnosed hyperthyroid children concentrations of TSH fell below the limit of detection, whereas in the remaining three concentrations were in the low normal range. Knowledge of the TSH fluctuations during medical treatment (antithyroid drugs or radioactive iodine plus 127 I) were useful in insuring a smooth clinical course. Elevations in TSH above 10 ng/ml served to indicate a need for change in therapy. Radical subtotal thyroidectomy evoked an acute compensatory rise (> 20 ng/ml) in TSH levels which was sometimes sufficient to maintain the level of serum thyroxine above 4 ^ig/100 ml. Hemithyroidectomy did not influence TSH or other thyroid parameters in previously euthyroid subjects.There was a clear separation between normal subjects and patients with primary hypothyroidism with values for TSH always exceeding 20 ng/ml in the latter. The TSH levels were below 3.7 ng/ml in pituitary hypothyroidism. In hypothyroid patients receiving adequate replacement therapy, elevations of serum TSH of > 20 ng/ml were encountered 2 weeks after discontinuation of treatment.Investigation of the pituitary-thyroidal axis in two untreated cretinous infants showed preservation of the functional integrity of the pituitary-thyroidal feedback system despite prenatal thyroid insufficiency as evidenced by a fall of TSH from levels >80 to <5 ng/ml in the presence of free thyroxine (FT 4 ) levels >2 ng/100 ml.In three patients (two females and one male) with longstanding juvenile hypothyroidism and TSH levels >80 ng/ml, pituitary dysfunctions characterized by luteinizing hormone (LH) concentrations above 20 mlU/ml and blunted growth hormone (HGH) responses to hypoglycemia were documented prior to therapy. Only the male had evidence of sexual precocity on physical examination. All three showed an abnormal circadian rhythm of cortisol secretion manifested by 8 PM values greater than 10 jug/100 ml. Acute restoration of euthyroidism in the two girls by means of parenteral thyroxine (T 4 ) improved the HGH response and normalized the cortisol rhythms in 72 hr, coincident with a sharp decline in TSH levels toward normal. In contrast, the high levels of LH declined much more slowly, failing to reach normal for as long as 7 weeks posttreatment.TSH in company with T 4 measurements permitted segregation of patients with Hashimoto's thyroiditis into three groups: (a) euthyroid with normal TSH and T 4 , 28Thyrotropin behavior in childhood thyroid disorders 29 (b) compensated with TSH values ranging between 19 and 28 ng/ml and T 4 in the 6-8 /zg/100 ml range, and (c) hypothyroid with T 4 below 3 ^g/100 ml and TSH values greater than 40 ng/ml. Speculation

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Section: Normal Subjectsmentioning

confidence: 65%

“…[30] and of Utiger [39], modified as described below. Human TSH (h-TSH) and anti-h-TSH serum were highly purified preparations [43].…”

Section: Methodsmentioning

confidence: 99%

Thyrotropin Behavior in Thyroid Disorders of Childhood

1973

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“…Even in prolonged exposure to cold, TSH elevation was transient, followed by a return toward the basal level (Itoh et al, 1966;Hefco et al, 1975). Most studies in human adults, on the contrary, failed to find not only the brief elevation of the serum TSH level by acute body cooling (Odell et al, 1967;Golstein-Golaire et al, 1970;Hershman et al, 1970;Fisher et al, 1971) but also any seasonal changes in serum TSH concentration despite the elevated serum or urinary thyroid hormone concentrations (Hedstrand and Wide, 1973;Rastogi and Sawhney, 1976;Nagata et al, 1976). Although only one dose of TRH (500 pg) was tested in the present study, the similar TSH response to TRH both in summer and in winter also indicated that the TSH secretory responsiveness of the pituitary to TRH remained unchanged in winter despite the elevated serum T3 concentration.…”

Section: Discussionmentioning

confidence: 99%

Comparison between the thyrotropin response to thyrotropin-releasing hormone in summer and that in winter in normal subjects.

Konno

1978

Endocrinol Japon

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“…Die sogenannte Insulin-Reserve, dargestellt als Quotient von Delta-Insulin über Delta-Glucose bei oraler Glucosebelastung ist bei der Hypo-thyreose normal (HANN, 1969). Der Insulinempfindlichkeits-Koeffizient ist bei intravenöser Glucosebelastung dagegen erniedrigt (NOLTE et al, 1972) ODELL et al (1967), die bei Änderungen der Blutzucker-Spiegel keine Beeinflussung der TSH-Sekretion feststellen konn ten.…”

Section: B) Hypothyreoseunclassified

Die Stoffwechselwirkungen der Schilddrüsenhormone

Dieterle¹,

Scriba²

1975

Diabetes Mellitus · A

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Studies of Thyrotropin Physiology by Means of Radioimmunoassay

Cited by 205 publications

References 46 publications

Thyrotropin Behavior in Thyroid Disorders of Childhood

Thyrotropin Behavior in Thyroid Disorders of Childhood

Comparison between the thyrotropin response to thyrotropin-releasing hormone in summer and that in winter in normal subjects.

Die Stoffwechselwirkungen der Schilddrüsenhormone

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