Studies of Unbound Amino Acid Distributions in Plasma, Erythrocytes, Leukocytes and Urine of Normal Human Subjects

McMenamy, Rapier H.; Lund, Charles C.; Neville, Gerald J.; Wallach, Donald F. Hoelzl

doi:10.1172/jci104191

Cited by 102 publications

(31 citation statements)

References 23 publications

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“…Kinetic analysis suggested that this common transport mechanism differs from that in gut and kidney. 4. No defect in the transport of the dibasic amino acids or cystine was found in leukocytes from cystinuric subjects.…”

Section: Discussionmentioning

confidence: 90%

“…The packed cell volume of leukocytes per milliliter of cell suspension ranged from 4.5 to 10.8% with a mean of 6.5%o. The number 4 New England Nuclear Corp., Boston, Mass. 5 Metabolic activity of the isolated leukocytes was demonstrated in three ways.…”

Section: Resultsmentioning

confidence: 99%

“…If the saturable portion of the transport process is thought of as a reaction conforming to the Michaelis-Menten equation, Y is given by the following expression: VmaxAf Km + Aft [4] '/Af take of glycine, AIB, and glutamic acid (Table II and Figure 3) can be explained by such a process. To determine whether the observed uphill transport of alanine, ACPC, lysine, and arginine was associated with the presence of saturable binding sites, the following studies were undertaken.…”

Section: Resultsmentioning

confidence: 99%

“…Several investigators (2)(3)(4) have reported that the free amino acid content of normal and leukemic leukocytes far exceeds that of plasma, suggesting that these cells maintain "uphill" concentration gradients in vivo. Yunis, Arimura, and Kipnis (5) showed that leukemic lymphocytes and granulocytes can accumulate a variety of neutral amino acids in vitro by processes that are sodium dependent and ouabain sensitive.…”

mentioning

confidence: 99%

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Transport of Neutral and Dibasic Amino Acids by Human Leukocytes: Absence of Defect in Cystinuria*

Rosenberg¹,

Downing²

1965

J. Clin. Invest.

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Section: Discussionmentioning

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

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Transport of Neutral and Dibasic Amino Acids by Human Leukocytes: Absence of Defect in Cystinuria*

Rosenberg¹,

Downing²

1965

J. Clin. Invest.

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“…McMenamy and his co-workers have shown that in humans, all the tyrosine in plasma (McMenamy, Lund & Oncley, 1957) and in erythrocytes (McMenamy et al, 1960) is diffusable and that the ratio of the mean concentrations (mol/kg water) erythrocytes/plasma was 1: 1-03, a value compatible with control of the tyrosine equilibrium being achieved by simple diffusion.…”

Section: Discussionmentioning

confidence: 97%

Interaction in the cerebral metabolism of the biogenic amines: Effect of intravenous infusion of l‐tryptophan on tryptophan and tyrosine in brain and body fluids

Moir

1971

British J Pharmacology

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Summary1. The distribution of the amino-acids tryptophan and tyrosine has been determined in plasma ultrafiltrate, whole plasma, erythrocytes, cerebrospinal fluid (c.s.f.) and various regions of the brain in dogs. 2. The effect of tryptophan administration on the distribution of both these amino-acids showed that the alterations produced in tryptophan concentration did not appear to change the concentrations of tyrosine from their normal pattern. 3. The implications of these results with regard to amino-acid transport systems in man and dog are discussed. IntroductionInteraction between the cerebral metabolism of tryptophan and dopamine has been demonstrated in dog brain (Moir, 1969;Moir & Yates, 1970;Moir, 1971). It was thought initially, in view of the experiments of Guroff & Udenfriend (1962) demonstrating that tryptophan inhibited the rate of uptake of radioactive tyrosine into rat brain, that the interaction demonstrated between the metabolism of the biogenic amines might be due to an interaction between their precursor amino-acids tryptophan and tyrosine. Because of this, concurrent estimations of these aminoacids were made in samples of various body fluids and brain regions during the experiments reported by Moir, 1971. These results are reported separately, as although they demonstrate many interesting features of the behaviour of the amino-acids, tryptophan and tyrosine, in brain and body fluids, they provide no evidence of any interaction between them.

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Amino Acids of Plasma and Urine in Diseases of Muscle

Bank¹,

Rowland²,

Ipsen³

1971

Archives of Neurology

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Studies of Unbound Amino Acid Distributions in Plasma, Erythrocytes, Leukocytes and Urine of Normal Human Subjects

Cited by 102 publications

References 23 publications

Transport of Neutral and Dibasic Amino Acids by Human Leukocytes: Absence of Defect in Cystinuria*

Transport of Neutral and Dibasic Amino Acids by Human Leukocytes: Absence of Defect in Cystinuria*

Interaction in the cerebral metabolism of the biogenic amines: Effect of intravenous infusion of l‐tryptophan on tryptophan and tyrosine in brain and body fluids

Amino Acids of Plasma and Urine in Diseases of Muscle

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