Studies of Urobilin Elimination in the Normal and Anemic Dog

Abstract

In congenital hemolytic icterus (1) and in pernicious anemia (2) splenectomy is followed by a decrease of the elimination of urobilin in the feces: As this decrease is coincident with an improvement in the blood picture, it is genecally assumed that the change in urobilin elimination is due to decreased destruction of blood. "It was in the hope of obtaining definite experimental evidence on this point that the present investigation was undertaken. Trypanosoma equiperdum has been employed to produce in dogs a continuous blood destruction which, as it endures over long periods of time, may be considered as practically a chronic experimental anemia. The elimination of urobilin has been studied both in the normal and splenectomized animal and in the anemic animal before and after splenectomy and treatment by arsenobenzol2 RESULTS.