Studies on 1,2:5,6-Dibenzanthracene Induced Mammary Carcinogenesis in Mice

Ranadive, K J; Karande, K A

doi:10.1038/bjc.1963.39

Cited by 12 publications

(5 citation statements)

References 7 publications

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“…Epidemiological data suggest that chronic exposure to specific environmental PAHs is strongly associated with many cancers, including that of the breast in women [ 208 ]. Their carcinogenic properties have further been corroborated by many animal studies [ 208 , 263 ].…”

Section: Xenoestrogens In Inflammation and Breast Cancermentioning

confidence: 84%

Natural and Synthetic Estrogens in Chronic Inflammation and Breast Cancer

Maharjan

Wang

et al. 2021

Cancers

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The oncogenic role of estrogen receptor (ER) signaling in breast cancer has long been established. Interaction of estrogen with estrogen receptor (ER) in the nucleus activates genomic pathways of estrogen signaling. In contrast, estrogen interaction with the cell membrane-bound G-protein-coupled estrogen receptor (GPER) activates the rapid receptor-mediated signaling transduction cascades. Aberrant estrogen signaling enhances mammary epithelial cell proliferation, survival, and angiogenesis, hence is an important step towards breast cancer initiation and progression. Meanwhile, a growing number of studies also provide evidence for estrogen’s pro- or anti-inflammatory roles. As other articles in this issue cover classic ER and GPER signaling mediated by estrogen, this review will discuss the crucial mechanisms by which estrogen signaling influences chronic inflammation and how that is involved in breast cancer. Xenoestrogens acquired from plant diet or exposure to industrial products constantly interact with and alter innate estrogen signaling at various levels. As such, they can modulate chronic inflammation and breast cancer development. Natural xenoestrogens generally have anti-inflammatory properties, which is consistent with their chemoprotective role in breast cancer. In contrast, synthetic xenoestrogens are proinflammatory and carcinogenic compounds that can increase the risk of breast cancer. This article also highlights important xenoestrogens with a particular focus on their role in inflammation and breast cancer. Improved understanding of the complex relationship between estrogens, inflammation, and breast cancer will guide clinical research on agents that could advance breast cancer prevention and therapy.

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Section: Xenoestrogens In Inflammation and Breast Cancermentioning

confidence: 84%

Natural and Synthetic Estrogens in Chronic Inflammation and Breast Cancer

Maharjan

Wang

et al. 2021

Cancers

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“…Table 2 summarizes the research on mammary carcinogenicity of several important, widely used toxic substances. These indude o,p '-DDT, some isomers of PCB, benzene, and several PAHs, including methylcholanthrene, dibenz[ah]anthracence, and DMBA (26)(27)(28). PAHs produce increased intracellular oxidation and chromosomal breaks or gene rearrangements (29).…”

Section: Experimental Evidencementioning

confidence: 99%

Medical Hypothesis: Xenoestrogens As Preventable Causes of Breast Cancer

Davis¹,

Bradlow²,

Wolff³

et al. 1993

Environmental Health Perspectives

198

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“…Other studies reporting the carcinogenicity of selected PAHs in laboratory animals include the following: Bingham and Falk 1979, Cook 1933, Horton and Christian 1974, Wynder and Hoffmann 1959a, Van Duuren, et al 1967, Lijinsky, et al 1965, Ranadine and Karande 1963, Hoffmann and Wynder 1966, Horton and Christian 1974.…”

Section: Carcinogenic Health Effects: Acute Exposurementioning

confidence: 99%