Studies on β-Lactam Antibiotics. III. Synthesis of 6-[D (-)-α-(Acylamino)-phenylacetamido] penicillanic Acids and Antibacterial Activity

(2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylato-κ2 O 4,O 5)(4-oxido-2-oxo-1,2-dihydropyrimidine-5-carboxylato-κ2 O 4,O 5)bis(1,10-phenanthroline-κ2 N,N′)yttrium(III) dihydrate

“…For the crystal structures of the isostructural Er, Eu, Tb and Yb complexes, see: Sun & Jin (2004); Xing et al (2008). For other related literature, see: Tobiki et al (1980); Castan et al (1990).…”

“…Data collection: APEX2 (Bruker, 2004); cell refinement: SAINT (Bruker, 2004); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: SHELXTL (Sheldrick, 2008); software used to prepare material for publication: SHELXTL. 2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid has attracted much attention because of its potential biological activity and pharmaceutical properties, such as anticancer, antibacterial and antihypertensive properties (Tobiki et al, 1980;Castan et al, 1990). Here we report the crystal structure of Y III complex with 2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid and 1,10-phenenthroline as ligands.…”

Synthesis and structure of ammonium isoorotate monohydrate and bis(isoorotato)manganese(II) dihydrate

“…Isoorotic acid [5-uracil carboxylic acid (see Fig. 1)] is a biologically and medically interesting compound; it exhibits anticancer, antibacterial and antihypertensive properties (Tobiki et al, 1980;Keichi et al, 1986). The complex of isoorotic acid with Cu H shows antibacterial activity (Hueso-Urena, Moreno-Carretero, Salas-Peregrin, ValenzuelaCalahorro & Alvarez de Cienfuegos-Lopez, 1988) and the complex of ethyl isoorotate with cisdiaquadiammineplatinum(II) has good antitumor, antibacterial and antiviral activity with low renal toxicity (Rosenberg, Van Camp, Fischer, Kansy, Peresie & Davidson, 1983).…”