Studies on Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and Genotype Distributions in Turkish Preeclampsia Patients

Bereketoğlu, Ceyhun; Kasap, Mülkiye; Pazarbaşı, Ayfer

doi:10.1155/2012/108206

Cited by 16 publications

(13 citation statements)

References 26 publications

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“…Uma et al (2010) found that the DD genotype of ACE was related to early-onset preeclampsia, although no marked changes in RAS were detected. A recent study by Bereketoglu et al (2012) also suggested a higher incidence of the DD genotype in Turkish preeclampsia patients in all the three modelscodominant, recessive, and dominant. Meanwhile, based on 30 case-control studies, a meta-analysis by Chen et al (2012) showed a strong relationship between the DD genotype of ACE and a higher risk of pregnancy hypertensive disorders, especially for Asians and Caucasians.…”

Section: Ace Polymorphism In Preeclampsiamentioning

confidence: 82%

The role of the renin–angiotensin–aldosterone system in preeclampsia: genetic polymorphisms and microRNA

Yang¹,

Shang²,

Zhang³

et al. 2013

Journal of Molecular Endocrinology

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The compensatory alterations in the rennin-angiotensin-aldosterone system (RAAS) contribute to the salt-water balance and sufficient placental perfusion for the subsequent well-being of the mother and fetus during normal pregnancy and is characterized by an increase in almost all the components of RAAS. Preeclampsia, however, breaks homeostasis and leads to a disturbance of this delicate equilibrium in RAAS both for circulation and the uteroplacental unit. Despite being a major cause for maternal and neonatal morbidity and mortality, the pathogenesis of preeclampsia remains elusive, where RAAS has been long considered to be involved. Epidemiological studies have indicated that preeclampsia is a multifactorial disease with a strong familial predisposition regardless of variations in ethnic, socioeconomic, and geographic features. The heritable allelic variations, especially the genetic polymorphisms in RAAS, could be the foundation for the genetics of preeclampsia and hence are related to the development of preeclampsia. Furthermore, at a posttranscriptional level, miRNA can interact with the targeted site within the 3 0 -UTR of the RAAS gene and thereby might participate in the regulation of RAAS and the pathology of preeclampsia. In this review, we discuss the recent achievements of genetic polymorphisms, as well as the interactions between maternal and fetal genotypes, and miRNA posttranscriptional regulation associated with RAAS in preeclampsia. The results are controversial but utterly inspiring and attractive in terms of potential prognostic significance. Although many studies suggest positive associations with genetic mutations and increased risk for preeclampsia, more meticulously designed large-scale investigations are needed to avoid the interference from different variations.

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Section: Ace Polymorphism In Preeclampsiamentioning

confidence: 82%

The role of the renin–angiotensin–aldosterone system in preeclampsia: genetic polymorphisms and microRNA

Yang¹,

Shang²,

Zhang³

et al. 2013

Journal of Molecular Endocrinology

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“…Inhibition/prevention of angiotensin II production has been reported to be beneficial in the prevention of type 2 diabetes as an increase in angiotensin II level contributes to insulin insensitivity in the peripheral tissues (Chu and Leung 2009). Bereketoglu et al (2012) also agreed that prevention of angiotensin II formation by the inhibition of ACE activity could be a useful therapeutic approach in the management of high blood pressure in both diabetic and non-diabetic patients.…”

Section: Introductionmentioning

confidence: 98%

Biological activities, antioxidant properties and phytoconstituents of essential oil from sweet basil (Ocimum basilicum L.) leaves

2015

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This study investigated the biological activities of essential oil from sweet basil leaves via its effect on α-amylase, α-glucosidase and angiotensin-I-converting enzyme (ACE) activities, inhibition of Fe 2+ and sodium nitroprusside (SNP)-induced lipid peroxidation in rats' pancreas and heart homogenates. The phytoconstituents of the oil were analysed using gas chromatography (GC). The essential oil exhibited a dose-dependent inhibition of α-amylase (IC 50 =3.21 mg/mL), α-glucosidase (IC 50 =3.06 mg/mL) and ACE (IC 50 =0.89 mg/ mL) activities in vitro. The oil also inhibited both Fe 2+ -and SNP-induced lipid peroxidation in rats' pancreas and heart. The GC analysis revealed the presence of about 28 phytoconstituents, with limonene (47.40 %), borneol (8.66 %), geranial (6.93 %), neral (5.71 %), myrcene (4.68 %), β-caryophyllene (4.68 %), α-terpineol (4.60 %), 1,8-cineole (4.17 %), linalool (3.53 %), β-elemene (3.05 %), germacrene D (2.68 %), and terpinen-4-ol (2.21 %) being the most prominent. Thus, the antioxidant and enzyme inhibitory effects of the essential oil could be attributed to the presence of these phytochemicals, which could be the principle responsible for the antidiabetic and antihypertensive properties of the essential oil. This study therefore, could provide the possible rationale for the application of essential oil from sweet basil leaves as functional foods and nutraceutical ingredient in the management of type 2 diabetes and hypertension.

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“…It has been suggested that genetic factors such as gene polymorphisms of the RAS may play an important role in the regulation of blood pressure in PE [21,22,23]. We revealed that pregnant women carrying the TT genotype of the AGT gene are prone to early onset of severe PE, and serum VEGF, PlGF, and sFlt-1 together contribute to the pathogenesis of PE.…”

Section: Discussionmentioning

confidence: 75%

Association of Angiotensinogen Gene Polymorphisms and Angiogenic Factors with Preeclampsia in Chinese Women

Song¹,

Shou-zhen²,

Wang³

et al. 2013

Gynecol Obstet Invest

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Objective: To investigate the association of angiotensinogen (AGT) gene polymorphisms and angiogenic factors with preeclampsia (PE) in Chinese women. Methods: A study on Chinese women was performed. Detection of the M235T polymorphism of AGT gene was carried out by PCR. Using a χ² test, genotype and allele frequencies were compared in all groups. Maternal serum levels of vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt1) at gestation were compared between 92 women with PE and 100 controls by ELISA. Results: Compared to the controls, the AGT homozygous of TT genotype in PE occurred significantly more frequently and the T allele was observed to occur more frequently than the M allele (p < 0.05). sFlt1 was present in high quantities in the serum of women with PE and was associated with low levels of free VEGF and PlGF (p < 0.05). Plasma sFlt1 levels are higher in PE patients with TT heterozygotes compared with MM homozygotes, but PIGF is lower (p < 0.05). Plasma VEGF concentrations showed no significant difference. Conclusions: Our study showed that AGT M235T polymorphism is associated with PE in Chinese women. Furthermore, the gene polymorphism of the components of the renin-angiotensin system may contribute to the concentration alterations of sFlt1, VEGF, and PlGF in maternal serum, which causes disordered vasculogenesis contributing to PE.

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Studies on Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and Genotype Distributions in Turkish Preeclampsia Patients

Cited by 16 publications

References 26 publications

The role of the renin–angiotensin–aldosterone system in preeclampsia: genetic polymorphisms and microRNA

The role of the renin–angiotensin–aldosterone system in preeclampsia: genetic polymorphisms and microRNA

Biological activities, antioxidant properties and phytoconstituents of essential oil from sweet basil (Ocimum basilicum L.) leaves

Association of Angiotensinogen Gene Polymorphisms and Angiogenic Factors with Preeclampsia in Chinese Women

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