Studies on antagonism between porcine skin bacteria

Allaker, Robert P.; Lloyd, D. H.; Noble, W. C.

doi:10.1111/j.1365-2672.1989.tb04571.x

Cited by 14 publications

(3 citation statements)

References 10 publications

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“…"itro. [103][104][105][106][107] Gmeiner in 1908 was the first to note the synergistic relationship between staphylococci and follicular Demodex on the dog."' English and others and Norm reported bacterial receptors on the surface of the Demodex Staphylococcal antigens and host antibodies may form immunecomplexes which inhibit the T-lymphocyte response of the host so favouring the multiplication of both commensal organisms.…”

Section: Interactions Between Commensalsmentioning

confidence: 99%

A review of the biology of canine skin with respect to the commensals Staphylococcus intermedins, Demodex canis and Malassezia pachydermatis

Mason¹,

Mason

Lloyd

1996

Veterinary Dermatology

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Skin disease associated with the cutaneous commensal organisms Staphylococcus intermedius, Malassezia pachydermatis and Demodex canis is frequently encountered in veterinary medicine. In treatment the aim is elimination of the commensal, but recurrence of skin disease is not unusual. In this review, these potentially pathogenic commensals and their ecology are discussed with particular reference to skin biology and the surface ecosystem. The strategies employed by the micro‐organisms for survival and the defence mechanisms of the host are considered. Disease occurs when the virulence of the commensal overwhelms the resistance of the host. It is hoped that an understanding of the complex nature of the skin and its commensals will lead to a better understanding of those diseases associated with commensals and in consequence more effective treatment. Résumé— Les dermatoses associées aux organismes commensaux cutanés Staphylococcus intermedius, Malassezia pachydermatis et Demodex canis sont fréquentes en médecine vétérinaire. Le traitement vise àéliminer le commensal, mais les récidives sont fréquentes. Dans cet article, les commensaux potentiellement pathogènes et leur écologie sont discutés avec une référence particulière à la biologie cutanée et à l'écosystème de surface. Les stratégies employées par les microorganismes pour survivre et les mécanismes de défense de l'hote sont présentés. La pathologie se développe lorsque la virulence du commensal outrepasse la résistance de l'hote. Il faut espérer que la compréhension de la nature complexe de la peau et de ses commensaux, permettent une meilleure compréhension des pathologies associées à ces commensaux et par conséquent un traitement plus efficace. [Mason, I. S., Mason, K. V., Lloyd, D. H. A review of the biology of canine skin with respect to the commensals Staphylococcus intermedius, Demodex canis and Malassezia pachydermatis (Une revue de la biologie de la peau concernant les commensaux Staphylococcus intermedius, Demodex canis et Malassezia pachydermatis). Veterinary Dermatology 1996; 7: 119–132.] Resumen En medicina veterinaria son frecuentes las dermatopatías asociadas a los microorganismos comensales Staphylococcus intermedius, Demodex canis y Malassezia pachydermatis. El tratamiento busca la eliminatión del comensal, aunque no son raras las recidivas. En esta revisión se discute la ecología de estos comensales potencialmente patógenos, con especial énfasis en la biologia cutánea y el ecosistema superficial. Se tienen en cuenta las estrategias para la supervivencia utilizadas por los microorganismos y los mecanismos de defensa del huésped. La enfernedad se desarrolla cuando la virulencia del comensal supera la resistencia del huésped. Se espera que el mejor conocimiento de la naturaleza compleja de la piel y de sus comensales llevará a un mejor conocimiento de las enfermedades asociadas a los comensales y, consecuentemente, a un tratamiento más efectivo. [Mason, I. S., Mason, K. V., Lloyd, D. H. A review of the biology of canine skin with respec...

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Section: Interactions Between Commensalsmentioning

confidence: 99%

A review of the biology of canine skin with respect to the commensals Staphylococcus intermedins, Demodex canis and Malassezia pachydermatis

Mason¹,

Mason

Lloyd

1996

Veterinary Dermatology

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“…Staphylococcus warneri was shown to produce substances that inhibited the growth of Staph. hyicus in vitro (Allaker et al 1989), and both Staph. warneri and Staph.…”

Section: Discussionmentioning

confidence: 98%

Development of a skin colonization model in gnotobiotic piglets for the study of the microbial ecology of meticillin-resistant Staphylococcus aureus ST398

et al. 2012

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Aims Meticillin‐resistant Staphylococcus aureus (MRSA) ST398 continues to spread amongst pigs and other domestic animals and man. This highlights the need for models to examine MRSA colonization and investigate control strategies. This study aimed to develop a gnotobiotic pig model and assess the potential of bacterial interference from selected coagulase‐negative staphylococci (CNS) against MRSA ST398. Methods and Results Groups of 2‐week‐old piglets were atraumatically inoculated either with MRSA and/or CNS. Skin and mucosae were swabbed, and bacterial counts compared over a period of 21 days. Piglets developed healthily, and bacterial populations increased similarly for both MRSA and CNS until day 32. On day 37, MRSA counts in groups with CNS reduced significantly compared with MRSA alone (P = 0·03). Conclusions The results showed that inoculation of piglet skin with MRSA resulted in spontaneous colonization and that MRSA ST398 has a low pathogenic potential in gnotobiotic piglets. Quantitative bacteriology indicated that initial MRSA colonization was unaffected by concurrent CNS colonization but that interference may occur over a longer period. Significance and Impact of the Study Gnotobiotic piglets provide a reproducible model suitable for bacterial interference studies, which should be further explored as an alternative to antimicrobials in the control of MRSA.

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“…Both S. hyicus strains were isolated from cases of exudative epidermitis; their virulence and colonisa-Correspondence to Dr R. P. Allaker tion patterns had been examined in previous studies in gnotobiotic piglets (4). The S. chromogenes strain was isolated from a healthy piglet and was shown to inhibit the growth of both S. hyicus strains to a similar level using simple direct and deferred inhibition tests (5).…”

mentioning

confidence: 99%

Interaction of Staphylococcus hyicus and an inhibitor producing strain of Staphylococcus chromogenes on the skin of gnotobiotic piglets

Allaker

Lloyd

Lamport

1990

Veterinary Dermatology

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Abstract— The effects of an inhibitor‐producing strain of Staphylococcus chromogenes on the colonisation and disease produced by virulent and avirulent strains of Staphylococcus hyicus were examined. In the presence of S. chromogenes the colonisation of the virulent strain was reduced one thousand fold and the onset of lesions was delayed by 7 days. The ability of the avirulent strain of S. hyicus to colonise skin was greatly reduced and populations became almost undetectable within 6 days of inoculation. Résumeé— Les effets d'une souche de Staphylococcus chromogenes, productrice d'un facteur d'inhibition, ont été examinés sur la colonisation et la maladie produites par des souches non virulentes et virulentes de Staphylococcus hyicus. En présence de S. chromogenes, la colonisation de la souche virulente a été réduite de 1000 fois, et l'apparition des lésions a été retardée de 7 jours. La faculté pour la souche non virulente de S. hyicus de coloniser la peau a été considérablement réduite et les populations sont devenues à peu près introuvables 6 jours après l'inoculation. Zusammenfassung— Die Wirkungen Inhibitor‐produzierenden Art von Staphylococcus chromogenes auf die Kolonisierung und Erkrankung der Haut durch virulente und avirulente Arten von Staphylococcus hyicus wurden untersucht. In Gegenwart von S. chromogenes wurde die Kolonisierung der virulenten Art um den Faktor 1000 verringert und des Auftreten der Hautveränderungen um 7 Tage verzögert. Die Fähigkeit zur Kolonisierung der Haut durch die avirulente 5. hyicus‐Art wurde sehr stark verringert, ihre Population konnte innerhalb von 6 Tagen nach Inokulation nicht mehr nachgewiesen werden. Resumen Se estudian los efectos de una cepa de Staphylococcus chromogenes productora de un inhibidor sobre la colonización y la enfermedad producida por cepas virulentas y avirulentas de Staphylococcus hyicus. En presencia de S. chromogenes la colonización de cepas virulentas se redujo a una milésima parte y la aparición de lesiones se retrasó 7 días. La capacidad de cepas avirulentas de S. hyicus para colonizar la piel se vió fuertemente reducida y las poblaciones bacterianas eran prácticamente no detectables a los 6 días de la inoculación.

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Studies on antagonism between porcine skin bacteria

Cited by 14 publications

References 10 publications

A review of the biology of canine skin with respect to the commensals Staphylococcus intermedins, Demodex canis and Malassezia pachydermatis

A review of the biology of canine skin with respect to the commensals Staphylococcus intermedins, Demodex canis and Malassezia pachydermatis

Development of a skin colonization model in gnotobiotic piglets for the study of the microbial ecology of meticillin-resistant Staphylococcus aureus ST398

Interaction of Staphylococcus hyicus and an inhibitor producing strain of Staphylococcus chromogenes on the skin of gnotobiotic piglets

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