1986
DOI: 10.2307/3281499
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Studies on Anthelmintic Effects of Flubendazole and Mebendazole on the Rat Lungworm Angiostrongylus cantonensis in Mice and Rats

Abstract: Flubendazole and mebendazole given orally at 10 mg/kg/day 5-7 days post-infection (total 30 mg/kg) were found to eliminate 93-100% of Angiostrongylus cantonensis larvae in mice and rats. No significant difference was observed between the effects of the 2 drugs. The effectiveness of the drugs decreased with the increase in days post-infection on which medication was administered. It was found possible to treat A. cantonensis adults in rats by administering flubendazole or mebendazole at 10 mg/kg/day for 10 cons… Show more

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Cited by 13 publications
(9 citation statements)
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“…Mebendazole was effective in the treatment of infection with A. cantonensis in mice and rats. 4 Theoretically, the neurologic symptoms should be exacerbated as a result of the death larvae. However, the combination of mebendazole and dexamethasone was used clinically without serious side effects.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Mebendazole was effective in the treatment of infection with A. cantonensis in mice and rats. 4 Theoretically, the neurologic symptoms should be exacerbated as a result of the death larvae. However, the combination of mebendazole and dexamethasone was used clinically without serious side effects.…”
Section: Discussionmentioning
confidence: 99%
“…Thiabendazole, mebendazole, and albendazole have some effect in animal infections. [3][4][5] Thiabendazole was ineffective in treatment of human angiostrongyliasis. 6 Albendazole or the combination of prednisolone and albendazole have been used clinically with good results.…”
Section: Introductionmentioning
confidence: 99%
“…Several effective anthelmintics, including mebendazole, flubendazole, and albendazole, have been used in the experimental treatment of A. cantonensis infection in animals (Maki and Yanagisawa 1986;Hwang and Chen 1988). The modes of action of these compounds are very similar (inhibition of glucose absorption by the nematode) (James and Gilles 1985).…”
Section: Discussionmentioning
confidence: 98%
“…MAKI & YANAGISAWA 30 gave flubendazole and mebendazole po at 10 mg/kg/day 5-7 days post-infection (total 30 mg/kg), resulting in 93-100% reduction of A. cantonensis larvae in mice and rats. No significant difference was observed between the effects of the two drugs.…”
Section: Chemotherapy Before Worm Maturationmentioning
confidence: 99%