Studies on Anti-Depressant Activity of Four Flavonoids Isolated from &lt;i&gt;Apocynum venetum&lt;/i&gt; Linn (Apocynaceae) Leaf in Mice

Yan, Shao-Xiao; Lang, Jun-Lian; Song, Yan-Ying; Wu, Yu-Ze; Lv, Menghan; Xia, Zhao; Liu, Yanhong; Chen, Xu

doi:10.4314/tjpr.v14i12.17

Cited by 14 publications

(8 citation statements)

References 18 publications

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“…Among these compounds, flavonols are the major flavonoids. This result is consistent with the previous data [20,21], while more anthocyanins were detected. Quantitative analysis shows that flavonols are the main differentiated flavonoids between the A. venetum and A. hendersonii leaf samples.…”

Section: Major Flavonoids Identified In a Venetum And A Hendersoniisupporting

confidence: 94%

Genomic Survey, Transcriptome, and Metabolome Analysis of Apocynum venetum and Apocynum hendersonii to Reveal Major Flavonoid Biosynthesis Pathways

Gao

Chen

et al. 2019

Metabolites

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Apocynum plants, especially A. venetum and A. hendersonii, are rich in flavonoids. In the present study, a whole genome survey of the two species was initially carried out to optimize the flavonoid biosynthesis-correlated gene mining. Then, the metabolome and transcriptome analyses were combined to elucidate the flavonoid biosynthesis pathways. Both species have small genome sizes of 232.80 Mb (A. venetum) and 233.74 Mb (A. hendersonii) and showed similar metabolite profiles with flavonols being the main differentiated flavonoids between the two specie. Positive correlation of gene expression levels (flavonone-3 hydroxylase, anthocyanidin reductase, and flavonoid 3-O-glucosyltransferase) and total flavonoid content were observed. The contents of quercitrin, hyperoside, and total anthocyanin in A. venetum were found to be much higher than in A. hendersonii, and such was thought to be the reason for the morphological difference in color of A. venetum and A. hendersonii. This study provides valuable genomic and metabolome information for understanding of A. venetum and A. hendersonii, and lays a foundation for elucidating Apocynum genus plant flavonoid biosynthesis.

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Section: Major Flavonoids Identified In a Venetum And A Hendersoniisupporting

confidence: 94%

Genomic Survey, Transcriptome, and Metabolome Analysis of Apocynum venetum and Apocynum hendersonii to Reveal Major Flavonoid Biosynthesis Pathways

Gao

Chen

et al. 2019

Metabolites

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“…Yan et al reported that kaempferol and quercetin have potential antidepressant-like activity. The mechanism was attributed to the increased levels of NE, dopamine (DA) and 5-HT [ 33 ]. Another study on quercetin proposes its antidepressant-like activity through its inhibitory effect on MAO-A, which is an important enzyme in the metabolism of the neurotransmitter, 5-HT.…”

Section: Discussionmentioning

confidence: 99%

In Silico Prediction of the Anti-Depression Mechanism of a Herbal Formula (Tiansi Liquid) Containing Morinda officinalis and Cuscuta chinensis

Cheng

Murtaza

et al. 2017

Molecules

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Purpose: Depression is a sickening psychiatric condition that is prevalent worldwide. To manage depression, the underlying modes of antidepressant effect of herbals are important to be explored for the development of natural drugs. Tiansi Liquid is a traditional Chinese medicine (TCM) that is prescribed for the management of depression, however its underlying mechanism of action is still uncertain. The purpose of this study was to systematically investigate the pharmacological mode of action of a herbal formula used in TCM for the treatment of depression. Methods: Based on literature search, an ingredients-targets database was developed for Tiansi Liquid, followed by the identification of targets related to depression. The interaction between these targets was evaluated on the basis of protein-protein interaction network constructed by STITCH and gene ontology (GO) enrichment analysis using ClueGO plugin. Results: As a result of literature search, 57 components in Tiansi Liquid formula and 106 potential targets of these ingredients were retrieved. A careful screening of these targets led to the identification of 42 potential targets associated with depression. Ultimately, 327 GO terms were found by analysis of gene functional annotation clusters and abundance value of these targets. Most of these terms were found to be closely related to depression. A significant number of protein targets such as IL10, MAPK1, PTGS2, AKT1, APOE, PPARA, MAPK1, MIF, NOS3 and TNF-α were found to be involved in the functioning of Tiansi Liquid against depression. Conclusions: The findings elaborate that Tiansi Liquid can be utilized to manage depression, however, multiple molecular mechanisms of action could be proposed for this effect. The observed core mechanisms could be the sensory perception of pain, regulation of lipid transport and lipopolysaccharide-mediated signaling pathway.

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“…Quercetrin (tetrahydroxyflavone) is a quercetin O-glycoside, in which quercetin is substituted with α-L-rhamnosyl moiety at position C3 via glycosidic linkage ( Figure 22 ) [ 100 ]. In another study, kaempferol, kaempferol-3-O-β-D-glucoside, quercetin, and quercetin3-O-β-D-glucoside ( Figure 23 ) isolated from hydroethanolic extract of Apocynum venetum L. leaves, were also found to exert significant anti-depressant actions in mice [ 101 ]. The underlying mechanism behind this effect was suggested to be increase in dopamine, serotonin and nor-epinephrine level with reduction in serotonin metabolism [ 101 ].…”

Section: Flavonoids and Structure Activity Relationshipmentioning

confidence: 99%

“…In another study, kaempferol, kaempferol-3-O-β-D-glucoside, quercetin, and quercetin3-O-β-D-glucoside ( Figure 23 ) isolated from hydroethanolic extract of Apocynum venetum L. leaves, were also found to exert significant anti-depressant actions in mice [ 101 ]. The underlying mechanism behind this effect was suggested to be increase in dopamine, serotonin and nor-epinephrine level with reduction in serotonin metabolism [ 101 ]. Kaempferol-3-O-β-D-glucoside is a trihydroxyflavone, which is also known as kaempferol O-glucoside and having glucosyl residue at position C3 of kaempferol via a β-glycosidic linkage ( Figure 24 ).…”

Section: Flavonoids and Structure Activity Relationshipmentioning

confidence: 99%

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Emerging Role of Flavonoids as the Treatment of Depression

et al. 2021

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Depression is one of the most frequently observed psychological disorders, affecting thoughts, feelings, behavior and a sense of well-being in person. As per the WHO, it is projected to be the primitive cause of various other diseases by 2030. Clinically, depression is treated by various types of synthetic medicines that have several limitations such as side-effects, slow-onset action, poor remission and response rates due to complicated pathophysiology involved with depression. Further, clinically, patients cannot be given the treatment unless it affects adversely the job or family. In addition, synthetic drugs are usually single targeted drugs. Unlike synthetic medicaments, there are many plants that have flavonoids and producing action on multiple molecular targets and exhibit anti-depressant action by affecting multiple neuronal transmissions or pathways such as noradrenergic, serotonergic, GABAnergic and dopaminergic; inhibition of monoamine oxidase and tropomyosin receptor kinase B; simultaneous increase in nerve growth and brain-derived neurotrophic factors. Such herbal drugs with flavonoids are likely to be useful in patients with sub-clinical depression. This review is an attempt to analyze pre-clinical studies, structural activity relationship and characteristics of reported isolated flavonoids, which may be considered for clinical trials for the development of therapeutically useful antidepressant.

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Studies on Anti-Depressant Activity of Four Flavonoids Isolated from <i>Apocynum venetum</i> Linn (Apocynaceae) Leaf in Mice

Cited by 14 publications

References 18 publications

Genomic Survey, Transcriptome, and Metabolome Analysis of Apocynum venetum and Apocynum hendersonii to Reveal Major Flavonoid Biosynthesis Pathways

Genomic Survey, Transcriptome, and Metabolome Analysis of Apocynum venetum and Apocynum hendersonii to Reveal Major Flavonoid Biosynthesis Pathways

In Silico Prediction of the Anti-Depression Mechanism of a Herbal Formula (Tiansi Liquid) Containing Morinda officinalis and Cuscuta chinensis

Emerging Role of Flavonoids as the Treatment of Depression

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