Studies on Antiulcer Agents. IV. Antiulcer Effects of 2-Benzylthio-5,6,7,8-tetrahydro-4(3H)-quinazolinones and Related Compounds.

Synthesis, spectro-analytical, computational and biological studies of novel 6-methyl-3-(1-(4-oxo-2-phenylquinazolin-3(4H)-ylimino) ethyl)-2H-pyran-2, 4(3H)-dione and its Co (II), Cu (II) and Hg (II) metal complexes

“…Quinazolinones are the heterocyclic compounds showing broad spectrum of biological significance such as anticancer [1], antitumour [2], antifungal [3,4], antibacterial [5,6], antitubercular [7], antihistaminic [8], antiinflammatory [9], anticonvulsant [10], immunotropic [11], hypolipidemic [12], antiulcer [13], analgesic [14,15] and CNS depressant [16] activities. The compound 3-acetyl-6-methyl-2H-Pyran-2, 4(3H)-dione upon complexation with transition metals exhibited numerous biological applications [17][18][19][20].…”

Design, synthesis, antimicrobial activity and anti-HIV activity evaluation of novel hybrid quinazoline–triazine derivatives

“…Several observations indicate that s-triazine analogues are the widely studied heterocyclic compounds owing to their broad spectrum of biological activity, including antimicrobial [7][8][9][10] , antimycobacterial 11 , anticancer 12,13 , antimalarial 14 and anti-HIV (NNRTIs) properties 15 . The biological importance of quinazoline had already stimulated the medicinal chemists to consider it as a building block due to its broad range of pharmacological properties, such as antimicrobial [16][17][18] , anti-HIV and anti-TMV (Tobacco Mosaic Virus) 19,20 , antitubercular 21 , anticancer 22 , anti-inflammatory 23 , anticonvulsant 24 , antidepressant 25 , hypolipidemic 26 , antiulcer 27 , analgesic 28 and immunotropic activities 29 . Moreover, piperazine heterocycles are valuable structural units in drug research [30][31][32][33][34][35][36] .…”

Synthesis, Spectroscopic Characterization and X-Ray Analysis of 6-Nitroquinazoline-2,4(1h,3h)-Dione

“…As medicines, many of them display antifungal 1 , antimicrobial 2 , anti-HIV 3 , antitubercular 4 , anticancer 5 , antiinflammatory 6 , anticonvulsant 7 , antidepressant 8 , hypolipidemic 9 , antiulcer 10 , analgesic 11 or immu-notropic activities 12 and are also known to act as thymidyalate synthase 13 , poly(ADP-ribose) polymerase (PARP) 14 , and protein tyrosine kinase 15 inhibitors. As pesticides, they are used as insecticides 16 and fungicides 17 .…”