Studies on Antiulcer Drugs. IV. Synthesis and Antiulcer Activities of Imidazo(1,2-a)pyridinylethylbenzothiazoles and -benzimidazoles.

Katsura, Yousuke; Inoue, Yoshikazu; Nishino, Shigetaka; Tomoi, Masaaki; Takasugi, Hisashi

doi:10.1248/cpb.40.1818

Cited by 23 publications

(20 citation statements)

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“…Benzoxazoles and other heterocycles are found in very important classes of bioactive compounds such as antibiotic, antibacterial, antiinflammatory, antistress, antiulcer, and anticancer agents [1][2][3][4][5][6][7]. They have recently received considerable attention for their pharmaceutical activities.…”

Section: Introductionmentioning

confidence: 99%

Application of SBA-Pr-SO3H in the synthesis of benzoxazole derivatives

et al. 2012

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Section: Introductionmentioning

confidence: 99%

Application of SBA-Pr-SO3H in the synthesis of benzoxazole derivatives

et al. 2012

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“…They also function as enzyme inhibitors and are effective on the central nervous system [12]. 2-Aminobenzothiazoles constitute another class of heterocycles that possess antimicrobial and various other pharmacological activities like diuretic, antiulcer, antihistamine and anticancer properties [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Activity of N-Substituted-3-chloro-2-azetidinones

Chavan¹,

Pai²

2007

Molecules

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2-Aminobenzothiazole-6-carboxylic acid (1), on condensation with chloroacetyl chloride yielded 2-(2-chloroacetylamino)benzothiazole-6-carboxylic acid (2), which on amination with hydrazine hydrate yielded in turn 2-(2-hydrazinoacetylamino)benzothiazole-6-carboxylic acid (3). Compound 3, on condensation with various aromatic aldehydes afforded a series of 2-{2-[N'-(arylidene)hydrazino]acetylamino}benzothiazole-6-carboxylic acids 4a-h, which upon dehydrative annulation in the presence of chloroacetyl chloride and triethylamine yielded 2-{2-[3-chloro-2-(aryl)-4-oxoazetidin-1-ylamino]-acetylamino}benzothiazole-6-carboxylic acids 5a-h. The synthesized compounds 4a-h and 5a-h were screened for their antibacterial activity against four microorganisms: Staphylococcus aureus (Gram positive), Bacillus subtilis (Gram positive), Psuedomonas aeruginosa (Gram negative) and Escherichia coli (Gram negative). They were found to exhibit good to moderate antibacterial activity. The antifungal activity of these compounds were also tested against three different fungal species. None of them were active against the species tested.

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“…16 Also 2-imino-thiazolidin-4-ones have been found to have antifungal activity. [17][18][19] Moreover literature survey reveals that 2-aminobenzothiazoles possess antimicrobial and various other pharmacological activities like diuretic, 20 anticancer, 21 antiulcer, 22 and antihistamine. 23 Hence it is thought of interest to accommodate thiazolidin-4-one and 2-amino benzothiazole moieties in single molecular framework and screen them for their antimicrobial activity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and antimicrobial screening of 5-arylidene-2-imino-4-thiazolidinones

Chavan¹,

Pai²

2007

Arkivoc

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The condensation of 2-aminobenzothiazole-6-carboxylic acid (1) with chloroacetyl chloride in refluxing chloroform in the presence of anhydrous K 2 CO 3 gives 2-(2-chloroacetylamino)benzothiazole-6-carboxylic acid (2). Compound (2) on treatment with KSCN in refluxing acetone yields 2-(2-imino-4-oxo-thiazolidin-3-yl)benzothiazole-6-carboxylic acid (3). Compound (3) on condensation with various aromatic aldehydes affords a series of 2-[5-(arylidene)-2-imino-4-oxo-thiazolidin-3-yl]benzothiazole-6-carboxylic acid (4a-h). The synthesized compounds (4a-h) are screened for their antibacterial as well as antifungal activity. All the tested compounds show slight to moderate activity against the selected microorganisms.

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Studies on Antiulcer Drugs. IV. Synthesis and Antiulcer Activities of Imidazo(1,2-a)pyridinylethylbenzothiazoles and -benzimidazoles.

Cited by 23 publications

References 0 publications

Application of SBA-Pr-SO3H in the synthesis of benzoxazole derivatives

Application of SBA-Pr-SO3H in the synthesis of benzoxazole derivatives

Synthesis and Biological Activity of N-Substituted-3-chloro-2-azetidinones

Synthesis and antimicrobial screening of 5-arylidene-2-imino-4-thiazolidinones

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