Studies on Attenuation of Post-Ischemic Brain Injury by Kampo Medicines-Inhibitory Effects of Free Radical Production. II

FUSHITANI, Shuji; MINAKUCHI, Kazuo; TSUCHIYA, Koichiro; Takasugi, Masumitsu; MURAKAMI, Kotaro

doi:10.1248/yakushi1947.115.8_611

Cited by 7 publications

(3 citation statements)

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“…Sekiya & Okuda (1982) showed it to be an inhibitor of leukotrienes and prostaglandin biosynthesis (attributed to one of its components, Scutellariae Radix, which contains baicalin and baicalein). Fushitani et al (1995) showed it to act as a scavenger of free radicals whilst Mori et al (1991) reported it to be an inhibitor of platelet aggregation (due to Coptidis Rhizoma and Phellodendri Cortex which affect the cyclic nucleotide metabolic system mainly through the action of Berberine). Wang et al (1997) reported it to be an attenuator of IL-8.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Oren-gedoku-to on Experimental Colitis in Rats

Zhou

Mineshita

1999

Journal of Pharmacy and Pharmacology

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In Japan and China, Oren-gedoku-to (a complex mixture of ingredients derived from plants) has been used as a herbal medicine in the treatment of inflammatory and ulcerative diseases. In other countries salicylazosulfapyridine has been used to treat inflammatory bowel disease. In this study, we have compared the effect of Oren-gedoku-to with salicylazosulfapyridine on trinitrobenzene-sulphonic acid-induced colonic damage in rats, a model representative of ulcerative colitis and Crohn's disease in man. Oren-gedoku-to was administered orally for one or two weeks over a range of doses. Tissue damage scores, body weight, spleen weight, colon wet weight and colon wall thickness were measured, and colonic tissue levels of interleukin-8 (IL-8), leukotriene B4 (LTB4), prostaglandin E2 (PGE2), and myeloperoxidase activity were examined. The results indicated that Oren-gedoku-to was effective in the treatment of inflammatory bowel disease in the rat model. Histological observation showed a quicker healing process of the lesions, and a reduction of inflammatory cell infiltration following administration of Oren-gedoku-to. The precise mechanism of action for Oren-gedoku-to is still unclear; however, the reduction of IL-8, LTB4, and PGE2 observed suggests that the mechanism may be different from salicylazosulfapyridine (which has no effect on IL-8). There may be a potential benefit in offering combination therapy for the treatment of inflammatory bowel disease.

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Section: Discussionmentioning

confidence: 99%

The Effect of Oren-gedoku-to on Experimental Colitis in Rats

Zhou

Mineshita

1999

Journal of Pharmacy and Pharmacology

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“…In addition to ROS source regulation, TCM preparation, Chinese materia medica and active compounds ameliorate I/R-induced oxidative stress by scavenging free radicals directly or by modulating tissue anti-oxidant potency. In a recently published study, three classical formulas (Huanglian Jiedu Tang, Chaihu Jia Longgu Muli Tang, and Guizhi Fuling Wan) showed scavenging activity for free-radical superoxide anion radicals, hydroxyl radicals and 1,1-diphenyl-2-picrylhydrazyl radical 2,2-diphenyl-1-(2,4,6-trinitrophenyl) hydrazyl (DPPH), respectively, while suppressing lipid peroxidation 55 . Another study reported that the single active component salvianolic acid A reduces the MDA contents in the cortex, hippocampus and corpus striatum in I/R rat brain, which may also attribute to its scavenging effect on free hydroxyl radicals in vitro 38 .…”

Section: Effects Of Tcm Preparation Chinese Materia Medica and Actimentioning

confidence: 99%

Ameliorating effects of traditional Chinese medicine preparation, Chinese materia medica and active compounds on ischemia/reperfusion-induced cerebral microcirculatory disturbances and neuron damage

Sun

Fan

Han

2015

Acta Pharmaceutica Sinica B

203

121

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Ischemic stroke and ischemia/reperfusion (I/R) injury induced by thrombolytic therapy are conditions with high mortality and serious long-term physical and cognitive disabilities. They have a major impact on global public health. These disorders are associated with multiple insults to the cerebral microcirculation, including reactive oxygen species (ROS) overproduction, leukocyte adhesion and infiltration, brain blood barrier (BBB) disruption, and capillary hypoperfusion, ultimately resulting in tissue edema, hemorrhage, brain injury and delayed neuron damage. Traditional Chinese medicine (TCM) has been used in China, Korea, Japan and other Asian countries for treatment of a wide range of diseases. In China, the usage of compound TCM preparation to treat cerebrovascular diseases dates back to the Han Dynasty. Even thousands of years earlier, the medical formulary recorded many classical prescriptions for treating cerebral I/R-related diseases. This review summarizes current information and underlying mechanisms regarding the ameliorating effects of compound TCM preparation, Chinese materia medica, and active components on I/R-induced cerebral microcirculatory disturbances, brain injury and neuron damage.

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“…There are also TCM prescriptions which have been used in CNS disorders. A TCM preparation, Oren-gedoku-to, demonstrated antioxidant [92][93][94] , anti-inflammatory 9 5 -9 7 and neuroprotective 9 8 -9 9 activities. However, there are TCM preparations of the plant which, despite their claim failed to improve declining memory.…”

Section: Evodia Rutaecarpa (Juss) Benth (Rutaceae)mentioning

confidence: 99%

An ANCIENT APPROACH BUT TURNING INTO FUTURE POTENTIAL SOURCE OF THERAPEUTICS IN ALZHEIMERâ€™S DISEASE

Singh¹

2015

Int. Res. J. Pharm.

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Dementia is one of the ages related mental problems and characteristic symptom of various neurodegenerative disorders including Alzheimer's disease which is age related. It is a progressive, neurodegenerative disorder which primarily affects the elderly population and it is considered to be responsible for 60 % of all dementia in people who are aged 65 or more. It is debilitating in nature, and due to which an enormous social and economic worry is placed on our society. Currently there is no proper cure for the disorder and much of the treatments available have been able to only delay the progression of the disease or provide symptomatic relief for a short time period. Therefore there is a need for a different approach to the treatment of these diseases. Plants have been used since ancient times in the treatment of various diseases including cognitive disorders, such as alzheimer's disease. Therefore ethno pharmacological screening of plants may provide useful leads in the discovery of new drugs for the treatment of alzheimer's disease. Screening of various plants is reviewed in this article, belonging to various families, used in traditional systems of medicine (e.g. Chinese, Indian and European) for treatment of cognitive dysfunction. Phytochemical substances such as alkaloids, biphenolic lignans, curcuminoids, caffeic acid derivatives, triterpenoids, and withanolides with pharmacological activities relevant to AD treatment are discussed in this review.

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Studies on Attenuation of Post-Ischemic Brain Injury by Kampo Medicines-Inhibitory Effects of Free Radical Production. II

Cited by 7 publications

References 0 publications

The Effect of Oren-gedoku-to on Experimental Colitis in Rats

The Effect of Oren-gedoku-to on Experimental Colitis in Rats

Ameliorating effects of traditional Chinese medicine preparation, Chinese materia medica and active compounds on ischemia/reperfusion-induced cerebral microcirculatory disturbances and neuron damage

An ANCIENT APPROACH BUT TURNING INTO FUTURE POTENTIAL SOURCE OF THERAPEUTICS IN ALZHEIMERâ€™S DISEASE

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