2002
DOI: 10.1080/10426500211731
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Studies on Azolylacetonitriles: The Reactivity of Thiazole-2-yl, Thiadiazol-2-yl Acetonitriles Toward Electrophilic Reagents

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Cited by 4 publications
(5 citation statements)
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“…2-(4-Chlorophenyl)-5-pyridin-2-yl-2H- [ 1 , 2 , 3 ] triazol-4-ylamine ( 6a ): Yellow crystals (80%); mp.167-169 o C; IR (cm -1 ): 3303, 3155 (NH 2 ); 1 H-NMR: δ = 6.30 (s, 2H, NH 2 ), 7.30-8.0 (m, 4H, pyr-H), 8.02 (d, 2H, J = 7.2 Hz, Ar-H), 8.6 (d, 2H, J = 7.2 Hz, Ar-H); 13 C-NMR: δ = 152.8, 150.7, 148.8, 137.9, 137.2, 132.1, 130.3, 129.4, 122.3, 119.7, 118.7; Anal. Calcd.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…2-(4-Chlorophenyl)-5-pyridin-2-yl-2H- [ 1 , 2 , 3 ] triazol-4-ylamine ( 6a ): Yellow crystals (80%); mp.167-169 o C; IR (cm -1 ): 3303, 3155 (NH 2 ); 1 H-NMR: δ = 6.30 (s, 2H, NH 2 ), 7.30-8.0 (m, 4H, pyr-H), 8.02 (d, 2H, J = 7.2 Hz, Ar-H), 8.6 (d, 2H, J = 7.2 Hz, Ar-H); 13 C-NMR: δ = 152.8, 150.7, 148.8, 137.9, 137.2, 132.1, 130.3, 129.4, 122.3, 119.7, 118.7; Anal. Calcd.…”
Section: Methodsmentioning
confidence: 99%
“…It is well accepted that the methylene moieties in heteroaromatic substituted acetonitriles are reactive toward electrophiles under mild conditions [ 1 , 2 , 3 ]. This reactivity has been utilized for synthesis of a variety of functionally substituted azoles [ 4 , 5 ] and condensed azoles [ 6 , 7 ].…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, the thiophene nucleus was proven to constitute the active part of several biologically active compounds . In continuation of our recent interest in the synthesis of heterocycles containing thiazole moiety . We report here the reaction of E ‐3‐(dimethylamino)‐1‐(4‐methyl‐2‐(tosylamino)thiazol‐5‐yl)prop‐2‐en‐1‐one ( 2 ) with phenyl isothiocayante and the utility of the product 3‐mercapto‐2‐(4‐methyl‐2‐(tosylamino)thiazole‐5‐carbonyl)‐3‐phenylaminopropenal ( 7 ) in the synthesis of the thiophene and 1,3,4‐thiadiazole derivatives.…”
Section: Introductionmentioning
confidence: 99%
“…In view of the aforementioned biological importance and in continuation of our interest in the synthesis of various heterocycles and its pharmacological properties , we report herein a facile synthetic strategy for synthesis of pyrazole, pyrazolo[1,5‐ a ][1,3,5]triazine, pyrazolo[1,5‐ a ]pyrimidines, imidazo[1,2‐ b ]pyrazole derivatives, and Schiff‐based derivatives linked to imidazo[2,1‐ b ]thiazole. The biological activities of the synthesized products will be reported in the extended work.…”
Section: Introductionmentioning
confidence: 99%