Studies on Bacteriophage Distribution

Dhillon, T. S.; Dhillon, Kamal

doi:10.1111/j.1348-0421.1972.tb00662.x

Cited by 33 publications

(4 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These phages exchange DNA in the laboratory and in nature, and their common genetic organization ensures that at least some of the recombinants will be viable (1)(2)(3)(4). We report the DNA sequence of a 2963 bp region extending rightwards of the cro gene in the right operon of the lambdoid bacteriophage HK022 (5,6). The region contains three major open reading frames that can be transcribed from the PR promoter, and their functions are suggested by sequence and chromosome comparisons.…”

Section: Resultsmentioning

confidence: 99%

A segment of the phage HK022 chromosome is a mosaic of other lambdoid chromosomes

1994

View full text Add to dashboard Cite

We report the sequence of a region of the PR operon of lambdoid phage HK022 and an analysis of the proteins it encodes. This region has DNA sequence elements and open reading frames that resemble those found in phages lambda, P22, and phi 80. The open reading frames encode homologs of the lambda CII transcription activator, the P22 DNA replication proteins, and a fourth protein of unknown function.

show abstract

Section: Resultsmentioning

confidence: 99%

A segment of the phage HK022 chromosome is a mosaic of other lambdoid chromosomes

1994

View full text Add to dashboard Cite

show abstract

“…Bacteriophage λ was isolated by UV induction of a lysogenic strain of Escherichia coli , and HK022 was isolated from sewage as previously described ( 4 , 5 ). Phage O276 was grown on E. coli MG1655 cells using standard procedures, and the genomic DNA was purified using the phenol-chloroform method ( 6 ).…”

Section: Announcementmentioning

confidence: 99%

Sequence Analysis of a Hybrid HK022/λ Bacteriophage and the Precise Identification of the λ b515 and λ b519 Deletion Endpoints

King

Perez

2018

Microbiol Resour Announc

View full text Add to dashboard Cite

show abstract

“…We became interested in a particular temperate phage that infects E. coli —HK022 (Dhillon and Dhillon, 1972)—because its integration site lies precisely between the genes torT and torS (Yagil et al, 1989). These genes produce a periplasmic binding protein and a sensor kinase, respectively, that together detect trimethylamine oxide (TMAO) in the periplasm and transduce this signal to the cytoplasm to phosphorylate the response regulator TorR.…”

Section: Introductionmentioning

confidence: 99%

Phage integration alters the respiratory strategy of its host

Carey

Mettert

Fishman-Engel

et al. 2019

eLife

View full text Add to dashboard Cite

Temperate bacteriophages are viruses that can incorporate their genomes into their bacterial hosts, existing there as prophages that refrain from killing the host cell until induced. Prophages are largely quiescent, but they can alter host phenotype through factors encoded in their genomes (often virulence factors) or by disrupting host genes as a result of integration. Here we describe another mechanism by which a prophage can modulate host phenotype. We show that a temperate phage that integrates in Escherichia coli reprograms host regulation of an anaerobic respiratory system, thereby inhibiting a bet hedging strategy. The phage exerts this effect by upregulating a host-encoded signal transduction protein through transcription initiated from a phage-encoded promoter. We further show that this phenomenon occurs not only in a laboratory strain of E. coli, but also in a natural isolate that contains a prophage at this site.

show abstract

Studies on Bacteriophage Distribution

Abstract: Twenty

Cited by 33 publications

References 14 publications

A segment of the phage HK022 chromosome is a mosaic of other lambdoid chromosomes

A segment of the phage HK022 chromosome is a mosaic of other lambdoid chromosomes

Sequence Analysis of a Hybrid HK022/λ Bacteriophage and the Precise Identification of the λ b515 and λ b519 Deletion Endpoints

Phage integration alters the respiratory strategy of its host

Contact Info

Product

Resources

About