Studies on bioactive compounds and therapeutic potential of <i>Terminalia chebula</i> seed extract

Plants have been well known for their medicinal applications for ages and traditional medicines are still a major part of habitual treatments in different parts of the world. They are used since ancient times for treating different ailments and providing valuable drugs such as analgesics (morphine), antihypertensives (reserpine), cardiotonic (digoxin) and antimalarials (quinine and artemisinin). The discovery of medicinal plants helps in achieving the new targets in treating various diseases like cancer, malaria and neurological disorders. Herbs proved to be the only solution for treating a large number of health-related problems. Most of the recent drugs are obtained in one or another way from plants. Medicinal plants contain biologically active, naturally occurring chemical compounds known as phytochemicals which provide health benefits and protect the human cell from any type of damage. Phytochemical screenings of medicinal plants have contributed to the discovery of new drugs. In our present investigation, an attempt has been made to screen out the bioactive constituents of three selected plants of western Himalayas and further they had been subjected to quantitative analysis for estimation of different parameters.

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Qualitative and Quantitative Analysis of Phytochemicals in some Medicinal plants of Western Himalayas

Manju

Aziz

Rehman

2022

RJPT

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Identification of metabolite compounds from ethanolic extract of the Red Gedi Leaves (Abelmoschus manihot L. Medik) by LC-ESI-MS

Tangka

Barung

Lyrawati

et al. 2022

RJPT

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Abelmoschus manihot L. Medic, commonly called ‘‘red gedi’’, is an endemic species of Minahasa, Indonesia. The leaves of red gedi have been widely used in ethnomedicine and functional food as an antidiabetic. In this study, the ethanolic extract of the red gedi leaves was characterized by using liquid chromatography coupled to electrospray ionization-tandem mass spectrometry (LC–ESI-MS). Compounds identified were phenolic acid derivates, flavonoids, terpenoids, phytosterols, alkaloids, and lignans. The most abundant flavonoids in the extract sample were quercetin derivatives. In total, 38 metabolite compounds were identified in red gedi leaves and were reported for the first time, including alpha spinasterol which is newly identified in this particular Abelmoschus species.

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The Role of Tambelo Extract (Bactronophorus thoracites) in Mice-Induced Lipopolysaccharide: Food Health Benefits

Leiwakabessy,

Yahya,

Fadjar

et al. 2023

RJPT

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Tambelo reportedly has a positive impact on health. Our study investigates the possible effect of tambelo extract as an anti-inflammatory in mice induced by lipopolysaccharide(LPS)Tambelo phytochemistry from liquid chromatography analysis – high-resolution mass spectrometry (LCMS) coupled with NF-κB protein, docking was carried out to pursue anti-inflammatory properties. Thirty Balb/C mice were randomized into six groups: untreated, LPS, dexamethasone + LPS, and tambelo extract with doses of 100, 150, and 200 mg/kg BW + LPS, respectively. The results of this study indicate that there are four compounds which has a high affinity for the target protein. High CD4+CD25+ expression after treatment with fermented products tambelo (BE) significantly attenuated LPS-induced mice (p<0.05). Our findings show that fermentation tambelo protects against induced LPS by maintaining Tregs. Tambelo may have the potential as a food choice due to its anti-inflammatory properties.

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Studies on bioactive compounds and therapeutic potential of Terminalia chebula seed extract

Cited by 4 publications

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Qualitative and Quantitative Analysis of Phytochemicals in some Medicinal plants of Western Himalayas

Qualitative and Quantitative Analysis of Phytochemicals in some Medicinal plants of Western Himalayas

Identification of metabolite compounds from ethanolic extract of the Red Gedi Leaves (Abelmoschus manihot L. Medik) by LC-ESI-MS

The Role of Tambelo Extract (Bactronophorus thoracites) in Mice-Induced Lipopolysaccharide: Food Health Benefits

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