Studies on Biochemical Effects of Aqueous Extract of Carica Papaya Leaf on Alloxan-Induced Diabetic Albino Rats

Ahamefula, Ezekwe; Constance, Nwadike; Ijeoma, Eboagwu; Prince, Njoku Samuel Odika

doi:10.25081/fb.2017.v6.3513

1970

DOI: 10.25081/fb.2017.v6.3513

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Studies on Biochemical Effects of Aqueous Extract of Carica Papaya Leaf on Alloxan-Induced Diabetic Albino Rats

Ezekwe Ahamefula

Nwadike Constance

Eboagwu Ijeoma

et al.

Abstract: Studies on biochemical effects of aqueous extract of Carica papaya leaf on alloxan-induced diabetic albino rats were undertaken. One hundred albino rats of Wistar strain were obtained and divided into five groups of twenty rats each and properly treated with the aqueous extract after four out of the five groups were induced with diabetes. The diabetic induced groups were diabetic control, test groups I (treated with 200 mg/kg) and II (treated with 50 mg/kg), and reference (treated with the standard glibenclami… Show more

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Assessment of the Hepato-protective Effects of Combined Ethanolic Extract of Psidium guajava and Carica papaya Leaves in Rats Challenged with Cadmium

Orororo¹

2023

NJPAS

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It has been shown that herbal extracts can protect intoxicated hepatocytes. Therefore, this study examined the hepato-protective effects of pooled ethanolic extract of Psidium guajava and Carica papaya leaves in rats challenged with Cadmium (Cd). Exactly 200g of the grounded leaves were soaked in ethanol for 48hours and was concentrated after filtration using a rotary evaporator. Fifteen adult female rats (150¬-±10g) were randomly assigned into three groups: Group 1 (control: received feed and water alone), Group 2 (Cd group; received single dose of Cd, 30mg/kg b wt, Group 3 (Cd + extract: received Cd as in group 2 and leaf extract 200mg/ kg bwt daily for 2 weeks). Rats were slaughtered and samples were taken for biochemical examination at the conclusion of the study period. When compared to controls, exposure to Cd alone resulted in a significant increase (p<0.05) in the activities of the alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH), as well as an increase in the level of total protein (TP). Hepatocytes exposed to cd underwent histological changes as well. As opposed to rats exposed to Cd alone, there was a significant decrease in the values of ALT, AST, ALP, LDH, and TP when Cd-challenged rats were given the combination ethanolic extract of P. guajava and C. papaya. The outcomes suggest that the biherbal combination of P. guajava and C. papaya can shield liver cells against Cd damage.

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Assessment of the Hepato-protective Effects of Combined Ethanolic Extract of Psidium guajava and Carica papaya Leaves in Rats Challenged with Cadmium

Orororo¹

2023

NJPAS

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Effects of Carica Papaya and Psidium Guajava Extracts on Hepato-Renal Performance of Streptozotocin-Induced Diabetic Male Albino Rats

Arshad

Azeem

Muzahir³

et al. 2021

PBMJ

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The growing number of diabetes coupled with the harsh side effects of some synthetic drugs has led to the increasing search for alternative medicine which are relatively cheap with minimum side effects. Objective: To investigate the anti-diabetic effect of ethanolic extract of Carica papaya and Psidium guajava extracts separately and in combination, and the effect of treatment on hepato-renal performance. Methods: Papaya and guava leaves were macerated in 98% ethanol for extraction. Results: The result showed that ethanolic leaf extract of P. guajava and C. papaya significantly (P< 0.05) reduced blood glucose level, Total Cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL) and significant increase in high density lipoprotein (HDL) as compared to diabetic control group. Serum activities of liver enzymes such as aspartate aminotransferase (AST), alkaline phosphatase (ALP) and alanine aminotransferase (ALT) was slightly elevated that indicate hepatotoxic nature of plant extracts. The level of gamma-glutamyl transferase (GGT), bilirubin and HbA1C level were restored to normal range. A slight reduction in body weight (P>0.05) of treated groups was observed. Serum urea and creatinine concentration was restored to normal level in treated rats with regeneration of kidney function. Conclusions: The study concluded that individual and combined plant extract show anti-hyperglycemic effect but the combined remedy at this dose show hepatotoxicity.

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Studies on Biochemical Effects of Aqueous Extract of Carica Papaya Leaf on Alloxan-Induced Diabetic Albino Rats

Cited by 2 publications

References 1 publication

Assessment of the Hepato-protective Effects of Combined Ethanolic Extract of Psidium guajava and Carica papaya Leaves in Rats Challenged with Cadmium

Assessment of the Hepato-protective Effects of Combined Ethanolic Extract of Psidium guajava and Carica papaya Leaves in Rats Challenged with Cadmium

Effects of Carica Papaya and Psidium Guajava Extracts on Hepato-Renal Performance of Streptozotocin-Induced Diabetic Male Albino Rats

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