Studies on Bromsulfalein Excretion

Models for Description of the Bromsulfalein Elimination Curves in Man after Single Intravenous Injections

“…It is known from bile collection studies (Cantarow et al 1948) and from experiments with Sa6-labelled bromsulfalein (Brauer et al 1955) that the major part of the dye is eliminated by the liver and excreted in the bile. Bromsulfalein is plasmaprotein-bound, when introduced into the blood, at concentrations such as are commonly used probably exclusively to serum albumin (Bradley et al 1945, Pezold 1953, Cohen et al 1956. Thus the general model should contain two connected volumes, representing the plasma volume and the liver, with an outlet of the latter representing biliary elimination.…”

Diseases of the Gastrointestinal Tract

“…However, when epinephrine, which may inhibit the uptake of glucose by the peripheral cells, was given before glucagon , the test appeared to have potential value. Cohen et al (159) showed that sulfobromophthalein has a greater affinity than rose bengal for the transfer mechanism concerned in the removal of dyes from the circulation and their excretion in the bile.…”