Studies on carcinoembryonic antigen levels in patients with adenocarcinoma of the uterus

Kjørstad, Kjell E.; Orjaseter, Harald

doi:10.1002/1097-0142(197712)40:6<2953::aid-cncr2820400630>3.0.co;2-0

Cited by 16 publications

(3 citation statements)

References 7 publications

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“…Endocrine changes were not found in this case, and estimations of serum polypeptide hormones or amines were not performed. Elevated levels of carcinoembryonic antigen have been reported in squamous cell carcinoma of the cervix (DiSaia et al, 1975;Kjorstad and Orjaseter, 1977) but the level found in this case is very high.…”

Section: Discussioncontrasting

confidence: 64%

Carcinoid tumour of the uterine cervix.

Warner¹

1978

J Clin Pathol

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Section: Discussioncontrasting

confidence: 64%

Carcinoid tumour of the uterine cervix.

Warner¹

1978

J Clin Pathol

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“…Apart from human chorionic gonadotropin in trophoblastic tumors, the only useful marker to date appears to be CEA, and positive rates exceeding 50% have been reported (3,5,17). Recent studies have shown a direct correlation between nodal metastases and the CEA level in cancer of the cervix (8), but not between tumor spread and the CEA level in cancer of the corpus (9). Differences in predictive accuracy of serial CEA levels in followup of ovarian cancer were shown to be related to the amount of postoperative residual tumor (6).…”

Section: Discussionmentioning

confidence: 99%

Carcinoembryonic Antigen and β₂‐Microglobulin as Serum Tumor Markers in Women with Genital Cancer

Khoo

Daunter

Mackay

1979

Intl J Gynecology & Obste

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A comparative study of carcinoembryonic antigen (CEA) and beta 2-microglobulin (beta 2-MG) in serum was made by radioimmunoassay in 77 women with genital cancer. With a positive level defined as 5 ng of CEA/ml and 3.0 microgram of beta 2-MG/ml, CEA was positive in 31% of the women with cancer of the corpus, 36% of those with cancer of the cervix and 36% of those with cancer of the ovary the corresponding figures for beta 2-MG were 6%, 27% and 56%, respectively. The additional use of beta 2-MG provided an increase in positive results, especially in cases of cancer of the ovary. A direct relationship between the extent of tumor and serum marker level was more evident for beta 2-MG than CEA. There was no correlation between serial levels of CEA and beta 2-MG in most patients. CEA levels appeared to predict subsequent tumor behavior more accurately in patients with good prognoses (ie, complete or partial tumor response), whereas beta 2-MG levels gave the same prediction in those with bad prognoses (ie, nonresponsive or progressive tumor).

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“…In tumors of the genital tract, a high level of plasma CEA was found to be associated with adenocarcinoma of the cervix more than with other histological types or with other localizations of the tumors. 11, 12 …”

Section: Discussionmentioning

confidence: 99%

Carcinoembryonic antigen (CEA) in plasma of patients with carcinoma of the bladder/urethra

Orjasaeter¹,

Fosså

Schjølseth

et al. 1978

Cancer

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A modified CEA-$oche kit was used to determine plasma CEA levels in 191 patients with carcinoma of the bladderhrethra. Pretreatment values were determined in 48 patients and values after previous treatment in a total of 177 cases. Serial CEA determinations were done in 140 patients. Among the untreated patients, 32% had elevated CEA compared to 41% in the group of previously treated patients with transitional cell carcinoma (TCC). Significant elevations were seen in the T1 stage as well as in the more advanced stages. T1 patients with no detectable tumors had normal CEA values with few exceptions. In patients with T2-T4 disease little difference was found between cases with tumor and those who were regarded as tumor free. No significant correlation was seen between CEA level and the grade of tumor differentiation in patients with TCC. The previohsly treated TCC patients had CEA levels which did not show any significant ,correlation to the clinical stage when CEA was determined. Even most of the patients with widespread metastases had only moderate increase of CEA. In the untreated patients a tendency to increased elevation was seen in the advanced stages. Serial determination of CEA showed a majority of cases with local recurrences that had CEA values within the normal range and following treatment the CEA value did not show corresponding fluctuation. The best correlation to clinical course was seen when comparing the pretreatment CEA level with the level after primary treatment where 5 out of 34 patients had a decrease in CEA after removal of the tumor. The Flinical value of CEA determinations seems to be limited mainly to patients with elevated CEA who are selected for radical treatment where persistance of CEA elevation may suggest incomplete removal of the tumor. Of special clinical interest was CEA determination in patients with adenocarcinoma and a small group (2-376) of patients with tumors classified as TCC of the bladder/ urethra. In these patients plasma CEA increased to high levels with advancing tumor growth, and elevations were seen before metastases were clinically detected. CEA also showed marked decrease after cancer therapy in these patients. The plasma CEA level seems to reflect biological or histogenetic differences in bladder carcinoma.

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Studies on carcinoembryonic antigen levels in patients with adenocarcinoma of the uterus

Cited by 16 publications

References 7 publications

Carcinoid tumour of the uterine cervix.

Carcinoid tumour of the uterine cervix.

Carcinoembryonic Antigen and β₂‐Microglobulin as Serum Tumor Markers in Women with Genital Cancer

Carcinoembryonic antigen (CEA) in plasma of patients with carcinoma of the bladder/urethra

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Studies on carcinoembryonic antigen levels in patients with adenocarcinoma of the uterus

Cited by 16 publications

References 7 publications

Carcinoid tumour of the uterine cervix.

Carcinoid tumour of the uterine cervix.

Carcinoembryonic Antigen and β2‐Microglobulin as Serum Tumor Markers in Women with Genital Cancer

Carcinoembryonic antigen (CEA) in plasma of patients with carcinoma of the bladder/urethra

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Carcinoembryonic Antigen and β₂‐Microglobulin as Serum Tumor Markers in Women with Genital Cancer