Studies on Chemotherapy of Vaccinia Virus

Brownlee, K. A.; Hamre, Dorothy

doi:10.1128/jb.61.2.127-134.1951

Cited by 34 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For estimating potency ratio of unknown and standard by the graded response. In the past, the graded response has been adapted to various assay uses with infectious microorganisms (Ipsen (1944), Pike and Mackenzie (1940), Gard (1940), and Brownlee and Hamre (1951)) and recently there appears to be a renewed interest in the method (Roth et al (1956), Fernelius et al (1958, and L'Heritier (1958)). The assay envisaged here is a bio-assay contrasting an "unknown" material to a "standard" by use of a graded response variable.…”

Section: Estimation Of Animal Requirements In Bio-assaymentioning

confidence: 99%

Number of Animals Required in the Bio-Assay of Pathogens

DeArmon¹,

Lincoln²

1959

J Bacteriol

View full text Add to dashboard Cite

Section: Estimation Of Animal Requirements In Bio-assaymentioning

confidence: 99%

Number of Animals Required in the Bio-Assay of Pathogens

DeArmon¹,

Lincoln²

1959

J Bacteriol

View full text Add to dashboard Cite

“…The search for antiviral compounds began in the 1950s when sulfonamide antibiotics were tested in the first in vitro antiviral trials using embryonated eggs [ 7 ]. As of 2016, about 90 antivirals are available for clinical use [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Tizoxanide Antiviral Activity on Dengue Virus Replication

Yamamoto

Blackburn

Goshe

et al. 2023

Viruses

View full text Add to dashboard Cite

Dengue virus is an important circulating arbovirus in Brazil responsible for high morbidity and mortality worldwide, representing a huge economic and social burden, in addition to affecting public health. In this study, the biological activity, toxicity, and antiviral activity against dengue virus type 2 (DENV-2) of tizoxanide (TIZ) was evaluated in Vero cell culture. TIZ has a broad spectrum of action in inhibiting different pathogens, including bacteria, protozoa, and viruses. Cells were infected for 1 h with DENV-2 and then treated for 24 h with different concentrations of the drug. The quantification of viral production indicated the antiviral activity of TIZ. The protein profiles in infected Vero cells treated and not treated with TIZ were analyzed using the label-free quantitative proteomic approach. TIZ was able to inhibit virus replication mainly intracellularly after DENV-2 penetration and before the complete replication of the viral genome. Additionally, the study of the protein profile of infected not-treated and infected-treated Vero cells showed that TIZ interferes with cellular processes such as intracellular trafficking and vesicle-mediated transport and post-translational modifications when added after infection. Our results also point to the activation of immune response genes that would eventually lead to a decrease of DENV-2 production. TIZ is a promising therapeutic molecule for the treatment of DENV-2 infections.

show abstract

A Short History of Research on Viruses

Collier

2010

Topley &Amp; Wilson's Microbiology and Microbial Infections

View full text Add to dashboard Cite

Studies on Chemotherapy of Vaccinia Virus

Cited by 34 publications

References 5 publications

Number of Animals Required in the Bio-Assay of Pathogens

Number of Animals Required in the Bio-Assay of Pathogens

Tizoxanide Antiviral Activity on Dengue Virus Replication

A Short History of Research on Viruses

Contact Info

Product

Resources

About