Studies on clinical signs and biochemical alteration in pregnancy toxemic goats

Vasava, P. R.; Jani, Rajesh; Goswami, H. V.; Rathwa, S. D.; Tandel, Falguni

doi:10.14202/vetworld.2016.869-874

Cited by 26 publications

(22 citation statements)

References 20 publications

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“…During this period, fetal growth between 80 and 140 days of pregnancy corresponded to 92.6% of the total weight of the fetus (Castagnino et al, 2015). Although it is reported that pregnancy toxemia lowers albumin serum concentrations (Vasava et al, 2016), the animals in this study continued to be healthy without any signs of disease.…”

Section: Discussionmentioning

confidence: 62%

“…Serum urea concentrations are used to diagnose ketosis in goats, and pregnant goats with subclinical or clinical ketosis were reported to have higher serum concentrations of urea than goats without pregnancy ketosis (Vasava et al, 2016). Although we did not perform any biochemical tests for subclinical ketosis, clinical ketosis was not detected.…”

Section: Discussionmentioning

confidence: 72%

“…Time and nutrition significantly affect the concentrations of albumin, protein, cholesterol and urea in goats, from 4 weeks pre-partum to 4 weeks post-partum (Castagnino et al, 2015). For instance, goats with pregnancy toxemia exhibited decreased albumin, protein, and cholesterol concentrations and increased serum urea, as compared with those of healthy goats (Vasava et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Metabolic Profiles of Healthy Pre- and Post-Partum Aardi Goats (Capra hircus) and Kids in Saudi Arabia

Al-Hassan¹

2018

PVJ

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Aardi goats are native to Saudi Arabia and represent the majority of its goat population. They are also known to have high genetic variability in comparison to other goat breeds found all over the world. When it comes to scientific data related to such an important breed, detailed information is lacking on how to help improve the production and reproduction of the breed. This study monitored the metabolic profiles by taking blood samples of Aardi goats weekly, from 4 weeks before until 4 weeks post-partum. In addition, weekly blood samples of their kids were taken until 4 weeks of age. Serum albumin, total protein, cholesterol, and urea concentrations were examined. Pre-partum serum albumin concentrations were significantly lower than those from the post-partum period. There was no significant difference in total protein concentrations between the pre-and post-partum periods. Serum cholesterol was significantly higher during the pre-than the post-partum period. Serum urea concentrations at 3 and 2 weeks pre-partum were significantly higher than those observed-1, 0, 2, 3, and 4 weeks from parturition, and the lowest concentrations were observed-1, 0, 3, and 4 weeks from parturition. In contrast to their mothers, serum cholesterol concentrations of kids increased from 1 to 4 weeks of age, while serum urea concentrations decreased in accordance with their mothers. These results indicate that Aardi goats have certain metabolic profiles that differ from other goat breeds during pre-and post-partum periods.

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Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

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Metabolic Profiles of Healthy Pre- and Post-Partum Aardi Goats (Capra hircus) and Kids in Saudi Arabia

Al-Hassan¹

2018

PVJ

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“…In fact, the impaired metabolism influences biological substances availability for lamb growth, with an increased risk of low birth weight, perinatal mortality and reduction of lambs’ performance [ 15 ]. A better knowledge of this disease would significantly improve the productivity [ 15 ] and the early diagnosis would allow a specific and effective management and medical treatment [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Milk Fatty Acids Composition Changes According to β-Hydroxybutyrate Concentrations in Ewes during Early Lactation

Fiore

Lisuzzo

Tessari

et al. 2021

Animals

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Ketosis is a metabolic disease of pregnant and lactating ewes linked to a negative energy balance which can cause different economic losses. The aims of this study were to understand the metabolic status of the early-lactating ewes and to identify biomarkers for early diagnosis of subclinical ketosis. Forty-six Sarda ewes were selected in the immediate post-partum for the collection of the biological samples. A blood sample from the jugular vein was used to determine β-Hydroxybutyrate (BHB) concentrations. Animals were divided into two groups: BHB 0 or healthy group (n = 28) with BHB concentration < 0.86 mmol/L; and BHB 1 or subclinical ketosis (n = 18) with a BHB concentration ≥ 0.86 mmol/L. Ten mL of pool milk were collected at the morning milking for the analyses. The concentration of 34 milk fatty acids was evaluated using gas chromatography. Two biochemical parameters and 11 milk fatty acids of the total lipid fraction presented a p-value ≤ 0.05. The study revealed different relationships with tricarboxylic acid cycle, blood flows, immune and nervous systems, cell functions, inflammatory response, and oxidative stress status. Eight parameters were significant for the receiver operating characteristic (ROC) analysis with an area under the curve greater than 0.70.

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“…Insulin and prolactin affect carbohydrate and lipid metabolism and can pose a risk of pregnancy toxemia [ 10 , 11 ], which occurs as a result of the negative energy balance due to the increased energy requirements of the fetus [ 12 , 13 ]. The hormonal effects in the late stages of pregnancy lead to decreased levels of glucose and increased fatty acid and ketone body concentrations in carbohydrate and fat metabolism [ 14 , 15 ]. The main indicators of sheep’s energy status are blood beta-hydroxybutyric acid (BHBA) and non-esterified fatty acid (NEFA) concentrations in the peripartum period [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Determination of natural antibodies, beta-hydroxybutyric acid, and non-esterified fatty acid levels in the serum of peripartum Tuj and Hemşin sheep

et al. 2021

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Background and Aim: Many metabolic and immunological changes occur during the transition period. Innate immunity plays an important role against to infections and natural antibodies (NAb) are important in immunity. This study aims to determine a connection between serum NAb titers, beta-hydroxybutyric acid (BHBA), and non-esterified fatty acid (NEFA) concentrations in Tuj and Hemsin sheep during the peripartum period. Materials and Methods: Serum NAb, BHBA, and NEFA levels were determined from the blood samples collected from Tuj and Hemsin sheep on days 30 and 15 before birth, on the day of birth (day 0), and on days 15 and 30 after birth. Results: NAb titers were found to be higher in Tuj than in Hemsin sheep (p<0.001). No statistically significant difference was found in serum BHBA concentrations of both breeds on all sampling days (p>0.05). The serum NEFA level was lower in Tuj sheep in the last 15 days of pregnancy compared to Hemsin sheep (p<0.05), while no difference was found in samples collected at the other time points. Conclusion: This study indicated that serum NAb titers significantly changed in Tuj and Hemsin sheep during the transition period. Serum BHBA and NEFA concentrations increased during the last stages of pregnancy and decreased after birth. Based on these findings, it is suggested that the immunological status could vary by the breed of sheep or various factors that affect the sheep's metabolic state.

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Studies on clinical signs and biochemical alteration in pregnancy toxemic goats

Cited by 26 publications

References 20 publications

Metabolic Profiles of Healthy Pre- and Post-Partum Aardi Goats (Capra hircus) and Kids in Saudi Arabia

Metabolic Profiles of Healthy Pre- and Post-Partum Aardi Goats (Capra hircus) and Kids in Saudi Arabia

Milk Fatty Acids Composition Changes According to β-Hydroxybutyrate Concentrations in Ewes during Early Lactation

Determination of natural antibodies, beta-hydroxybutyric acid, and non-esterified fatty acid levels in the serum of peripartum Tuj and Hemşin sheep

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