Studies on cloud point of agrochemical microemulsions

Chen, Fuliang; Wang, Yi; Zheng, Fang; Wu, Yitian; Liang, Wenping

doi:10.1016/s0927-7757(00)00505-7

Cited by 31 publications

(7 citation statements)

References 3 publications

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“…At temperatures higher than the cloud point, an irreversible phase separation occurs due to dehydration of its ingredients, which may affect drug absorption (Chen et al, 2000). Hence, to avoid this phenomenon, the cloud point for the SNEDDS formulation should be above body temperature (i.e.…”

Section: Discussionmentioning

confidence: 99%

Trans-resveratrol self-nano-emulsifying drug delivery system (SNEDDS) with enhanced bioavailability potential: optimization, pharmacokinetics andin situsingle pass intestinal perfusion (SPIP) studies

2014

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Trans-resveratrol (t-RVT) is a potent antioxidant. By virtue of extensive pre-systemic metabolism and existence of enterohepatic recirculation, t-RVT bioavailability is almost zero. The current study aimed to develop self-nanoemulsifying drug delivery systems (SNEDDS) using long-chain triglycerides (LCTs) of t-RVT in an attempt to circumvent such obstacles. Equilibrium solubility studies indicated the choice of Lauroglycol FCC as lipid, and of Labrasol and Transcutol P as surfactants, for formulating the SNEDDS. Ternary phase diagrams were constructed to select the areas of nanoemulsions, and the amounts of lipid (X 1 ) and surfactant (X 2 ) as the critical factor variables. The SNEDDS were optimized using 3 2 central composite design (CCD) and the optimized formulation (OPT) located using overlay plot. The nanometer size range and high negative values of zeta potential depicted non-coalescent nature of the SNEDDS. Optimized formulation indicated marked improvement in drug release profile vis-à-vis pure drug. Cloud point determination and accelerated stability studies ascertained the stability of OPT. Augmentation in the values of K a (3.29-fold) and AUC (4.31-fold) indicated significant enhancement in the rate and extent of bioavailability by the OPT compared with pure drug. In situ perfusion (SPIP) studies in Wistar rats construed remarkable enhancement in the absorptivity and permeability parameters of SNEDDS vis-à-vis the pure drug. Successful establishment of level A of in vitro/in vivo correlation substantiated the judicious choice of the in vitro dissolution milieu for simulating the in vivo conditions. The present study, therefore, reports the successful development of SNEDDS with distinctly enhanced bioavailability of t-RVT. KeywordsBioavailability, central composite design, in situ single pass intestinal perfusion, pharmacokinetic study, self-nanoemulsifying drug-delivery system History

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Section: Discussionmentioning

confidence: 99%

Trans-resveratrol self-nano-emulsifying drug delivery system (SNEDDS) with enhanced bioavailability potential: optimization, pharmacokinetics andin situsingle pass intestinal perfusion (SPIP) studies

2014

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“…Meanwhile, samples were stored at −18 °C for 7 days to observe the stability of the microemulsion. Finally, the cloud point was measured by gently stirring the sample in a water bath, with the temperature set to increase at 2.0 °C/min intervals, until the microemulsion became observably turbid 53 .…”

Section: Methodsmentioning

confidence: 99%

Microemulsion formulation of a new biopesticide to control the diamondback moth (Lepidoptera: Plutellidae)

Shao

Zhang

2018

Sci Rep

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This study was designed to develop a microemulsion formulation of norcantharidin for the control of the diamondback moth (DBM), Plutella xylostella (Linnaeus), a notorious pest of brassica crops worldwide. The oil phase was screened and selected based on norcantharidin solubility while the surfactants were selected on the basis of their efficiency to form microemulsion. Optimized batches were selected using pseudo ternary phase diagrams. The microemulsion system were stabilized using mixtures composed of norcantharidin, surfactants (Tx13 and Tw80), and cosurfactant (ethanol). Its physicochemical characteristics were also demonstrated to have a higher cloud point than 72 °C as well as good thermodynamic and dilution stability. In additon, a subsequent insecticidal bioassay indicated that the acute LC50 for norcantharidin microemulsion to P. xylostella was estimated to be 12.477 mg/L (11.58–13.41, 95% CL). Our results provide an environment-friendly promising alternative to control P. xylostella and possibly contribute to ameliorating any pesticide resistance in P. xylostella.

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“…The formulations that passed the centrifuged test were subjected to additional the storage test at 26 ± 1°C and 60 ± 5 % RH for three months and two weeks under 54±1°C. The selected formulations were stored according to the agrochemical products vertically prescribed by the Food and Agriculture Organization (FAO) as a standard evaluation to show stability in a tropical climate (Chen et al, 2000;Roland et al, 2003). The observations were made visually to observe any change in the physical appearance of the formulation's samples.…”

Section: Stability Of Oil Emulsion Formulations Under Storage Conditionsmentioning

confidence: 99%

Preparation and Characterization of Oil Nanoemulsion Formulations of Beauveria bassiana (Bals.-Criv.)

Alhilfi¹,

Swadi²,

Ahmed³

2021

Basrah J. Agric. Sci.

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This study aims to prepper stable thermodynamically dilutable nanoemulsion formulation of Beauveria bassiana with the lowest surfactant concentration that could improve its solubility stability. Formulations were prepared from oil in the water nanoemulsion region of phase diagrams subjected to thermodynamic stability tests. We found propanetriol was the highest germination rate at 5% and 10% concentration, 46.66 and 53.33%, respectively. Castor oil achieved a 43.00 germination rate at 1%. Tween 80 gave 54.33 % germination rate at 10%. While Tween 20 showed a 48 % germination rate at 5%. At the concentration, 1% Term 1284 gave 43.33% rate germination. Nanoemulsion composed of propanetriol and nonionic surfactants, with a mean particle size ranging from 25.08 to 75.35 nm, was formulated for various concentrations of the oils and surfactants. Water in oil emulsion was prepared using propanetriol oil, Tween 20, Tween 80, Term 1284, and water. Nanoemulsion of 25.08, 33.75, and 75.35 nm size was obtained at a 45: 15 % ratio of oil and surfactant, and it was found to be stable. The larger droplet size 75.35 nm of formulation Tween 20 and the smaller size was 25.08 nm in the formulation of Term 1284. The higher viscosity value was 16 mPas of formulation Tween 80, and the lowest value was 7.80 in the formulation of Term 1284. To demonstrate the possible employment of these systems, they were used to formulate a nanoformulation pesticide.

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Studies on cloud point of agrochemical microemulsions

Cited by 31 publications

References 3 publications

Trans-resveratrol self-nano-emulsifying drug delivery system (SNEDDS) with enhanced bioavailability potential: optimization, pharmacokinetics andin situsingle pass intestinal perfusion (SPIP) studies

Trans-resveratrol self-nano-emulsifying drug delivery system (SNEDDS) with enhanced bioavailability potential: optimization, pharmacokinetics andin situsingle pass intestinal perfusion (SPIP) studies

Microemulsion formulation of a new biopesticide to control the diamondback moth (Lepidoptera: Plutellidae)

Preparation and Characterization of Oil Nanoemulsion Formulations of Beauveria bassiana (Bals.-Criv.)

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