Studies on colloidal stability of PVP-coated LSMO nanoparticles for magnetic fluid hyperthermia

Jadhav, Swati V.; Nikam, Dipali S.; Khot, Vishwajeet M.; Thorat, Nanasaheb D.; Phadatare, M.R.; Ningthoujam, R. S.; Salunkhe, A.B.; Pawar, S.H.

doi:10.1039/c3nj00554b

Cited by 98 publications

(59 citation statements)

References 51 publications

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“…Liq and m Liq is the heat capacity and mass of solvent, respectively; m SPION is the iron oxide content, per gram, in suspension and ΔT/Δt is the initial slope of the time-dependent curve. The heat capacity of SPION is negligible due to the low concentration in fluid, thus the water's heat capacity (4.18 J K −1 ) was considered[45].…”

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confidence: 99%

PEGlatyon-SPION surface functionalization with folic acid for magnetic hyperthermia applications

Piazza

Viali

Santos

et al. 2020

Mater. Res. Express

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Superparamagnetic iron oxide nanoparticles (SPION) are of great interest for application in magnetic fluid hyperthermia (MFH) due to their heat generation capability in an external alternating magnetic field, besides biocompatibility, and surface properties. MFH has emerged as a promisor therapeutic approach for cancer treatment and is based in controlled heating tumor tissue through the accumulation of SPIONs within cancer cells. This work describes a new route for the preparation of folate-conjugated PEGylated SPIONs, which involves the attachment of such molecules at the surface through polycondensation reactions, without the need for coupling agents or prior modification on the species involved. The size of iron oxide cores obtained by transmission electron microscopy was about 12 nm. The conjugation of folate onto SPIONs was confirmed by FTIR spectroscopy. The folate conjugated nanoparticles were colloidal stable in PBS, presenting a hydrodynamic diameter of 109±1 nm and PDI 0.148. The obtained folate-targeted PEGylated SPIONs showed superparamagnetic behavior with a saturation magnetization of 73.1 emu·g −1 at 300 K. Their specific absorption rate (SAR) ranged from 32.8 to 15.0 W g −1 in an alternating magnetic field of 10-16 kA m −1 and frequency of 420-203 kHz. The heat generated was sufficient to raise the sample temperature to the therapeutic range used in MFH establishing this system as promising candidates for use in MFH treatment.

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confidence: 99%

PEGlatyon-SPION surface functionalization with folic acid for magnetic hyperthermia applications

Piazza

Viali

Santos

et al. 2020

Mater. Res. Express

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“…We have previously examined the dynamic magnetic properties of La 0.67 Sr 0.33 MnO 3 (LSMO) nanoparticles by AC magnetic susceptibility measurements; 13 the results indicated that the nanoparticles have an interacting superparamagnetic behavior above room temperature and are of interest for medical applications. [19][20][21][22] In the present research, we have studied the static magnetic properties, exchange bias, and memory effects. TEM and HRTEM micrographs and static magnetization measurements indicate particle and magnetic size distributions possessing a magnetic core-shell structure.…”

Section: Introductionmentioning

confidence: 99%

Magnetic properties, exchange bias, and memory effects in core-shell superparamagnetic nanoparticles of La0.67Sr0.33MnO3

Rostamnejadi

Venkatesan

Salamati

et al. 2017

Journal of Applied Physics

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The static magnetic properties and memory and exchange bias effects have been studied in sol-gel prepared La 0.67 Sr 0.33 MnO 3 (LSMO) nanoparticles. Transmission electron microscopy (TEM) micrographs and static magnetization show log-normal particle and magnetic size distributions with a core-shell structure. Analysis of the magnetization measurements indicates the presence of a magnetic structure with a 7.8 nm core radius and a magnetic dead layer of thickness 1.6 nm in the LSMO nanoparticles, which comprises about 40% of the volume. The disordered spins in the shell freeze at lower temperatures than the core and produce a surface spin glass state exhibiting a weak exchange bias effect. Field cooled and zero-field cooled magnetization measurements have been carried out to study the slow dynamics of the sample and associated magnetic memory effects; the results reveal the superparamagnetic behavior of LSMO nanoparticles described in terms of the magnetic size distribution rather than a superspin glass state. Published by AIP Publishing.

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“…Although this article does not include a study of toxicity, we will note some essential points. Many experiments on the coating La–Sr manganites with biocompatible shells including SiO 2 , dextran, citrate ligands, fatty amines, polyvinylpyrrolidone (PVP), etc. proved the colloidal stability and biocompatibility of LSMO NPs.…”

Section: Numerical Results and Discussionmentioning

confidence: 99%

“…Moreover, SAR depends strongly on magnitude and frequency of the applied magnetic field, so experimental results from disparate studies using disparate magnetic field are difficult to compare. For technical reasons there is a limit on the amplitude of the applied field to about 8÷16 kAm −1 .…”

Section: Introductionmentioning

confidence: 99%

La_1−xSr_xMnO₃ Nanoparticles for Magnetic Hyperthermia

Apostolov

Apostolova

Wesselinowa

2018

Physica Status Solidi (b)

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Using a modified Heisenberg model and a Green's function technique we have studied the influence of size d and concentration x of Sr dopants on the Curie temperature T C , saturation magnetization M S , coercivity H C and specific absorption rate (SAR) of single-domain La 1Àx Sr x MnO 3 nanoparticles. Their magnetic properties are explained based on the "magnetically death" surface layer and the competition between the ferromagnetic double-exchange and antiferromagnetic super-exchange interaction. We calculated the specific absorption rate which characterizes the efficiency of the absorption energy when the magnetic hyperthermia is applied as a therapeutic method for the treatment of tumors. A set of nanoparticles appropriate for in vivo and in vitro medical applications, such as magnetic hyperthermia and drug delivery to cancer cells, is determined. The established methodology and microscopic model are suitable to study the magnetic properties of low-dimensional systems (thin films and nanoparticles) such as La 1Àx A x MnO 3 with A ¼ Ca, Ag, Ba, Na for medical applications.

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Studies on colloidal stability of PVP-coated LSMO nanoparticles for magnetic fluid hyperthermia

Cited by 98 publications

References 51 publications

PEGlatyon-SPION surface functionalization with folic acid for magnetic hyperthermia applications

PEGlatyon-SPION surface functionalization with folic acid for magnetic hyperthermia applications

Magnetic properties, exchange bias, and memory effects in core-shell superparamagnetic nanoparticles of La0.67Sr0.33MnO3

La_1−xSr_xMnO₃ Nanoparticles for Magnetic Hyperthermia

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Studies on colloidal stability of PVP-coated LSMO nanoparticles for magnetic fluid hyperthermia

Cited by 98 publications

References 51 publications

PEGlatyon-SPION surface functionalization with folic acid for magnetic hyperthermia applications

PEGlatyon-SPION surface functionalization with folic acid for magnetic hyperthermia applications

Magnetic properties, exchange bias, and memory effects in core-shell superparamagnetic nanoparticles of La0.67Sr0.33MnO3

La1−xSrxMnO3 Nanoparticles for Magnetic Hyperthermia

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La_1−xSr_xMnO₃ Nanoparticles for Magnetic Hyperthermia