1948
DOI: 10.1093/brain/71.2.212
|View full text |Cite
|
Sign up to set email alerts
|

Studies on Copper Metabolism in Demyelinating Diseases of the Central Nervous System

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

1
36
0
1

Year Published

1953
1953
2009
2009

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 131 publications
(38 citation statements)
references
References 0 publications
1
36
0
1
Order By: Relevance
“…The patient in whom Wilson's disease is, or will be, clinically manifest exhibits four abnormalities of copper metabolism: 1) a persistent deficiency or absence of normal ceruloplasmins, the blue, plasma copper-proteins (3,5,6); 2) an increased concentration of loosely bound, non-ceruloplasmin copper in serum (6, 7); 3) an increased copper content of many organs and tissues (6, the urine (3,6,11,14). Although the mechanism is only partly understood, several investigators (3,11,15,16) believe that the first two of these derangements lead to the third, the pathological effects of which constitute Wilson's disease.…”
mentioning
confidence: 99%
“…The patient in whom Wilson's disease is, or will be, clinically manifest exhibits four abnormalities of copper metabolism: 1) a persistent deficiency or absence of normal ceruloplasmins, the blue, plasma copper-proteins (3,5,6); 2) an increased concentration of loosely bound, non-ceruloplasmin copper in serum (6, 7); 3) an increased copper content of many organs and tissues (6, the urine (3,6,11,14). Although the mechanism is only partly understood, several investigators (3,11,15,16) believe that the first two of these derangements lead to the third, the pathological effects of which constitute Wilson's disease.…”
mentioning
confidence: 99%
“…Collection of Specimens.-In the past, most workers have collected 24-hourly specimens of urine for copper analysis, but some have worked with specimens collected over shorter periods, such as two hours (Mandelbrote et al, 1948), or at random (e.g., Earl, 1954). These smaller specimens have the obvious advantage of convenience, and to determine whether they are comparable the urinary copper excretion of three subjects was followed throughout 24-hour periods.…”
Section: Methodsmentioning
confidence: 99%
“…Thus a comparatively high urinary excretion of copper has been found in hepatolenticular de-generation (Mandelbrote, Stanier, Thompson, and Thruston, 1948 ;Cumings, 1951 ;Porter, 1951;Matthews, Milne, and Bell, 1952;Zimdahl, Hyman, and Cook, 1953;Bearn, 1953 ;Earl, 1954) and an elevation of the copper content of the blood has been observed in infectious diseases and anaemias (Cartwright, 1950, and authors cited), but it should be noted that many of the values for patients with these diseases lie within the limits of normal ranges reported by other authors.…”
mentioning
confidence: 99%
“…The total serum copper concentration also is lower than normal (6,7), although the small fraction of copper bound to serum albumin, designated by Cartwright and his co-workers as the "direct-reacting copper," is increased (7). There is excessive urinary excretion of copper (8).…”
mentioning
confidence: 97%