Studies on Copper Metabolism. XXIII. Portal (Laennec's) Cirrhosis of the Liver1

Gubler, C. J.; Brown, Henry; Markowitz, Harold; Cartwright, G. E.; Wintrobe, M. M.

doi:10.1172/jci103517

Cited by 73 publications

(17 citation statements)

References 20 publications

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“…Thus, despite lack of direct proof, the hypothesis of dilution of copper into an expanded body pool of the metal has generally been accepted, presumably because it is inherently reasonable. There is, however, an alternative method of studying the problem; patients with primary biliary cirrhosis have concentrations ofcopper in their livers comparable with those found in the livers of patients with Wilson's disease (Gubler, Brown, Markowitz, Cartwright & Wintrobe, 1957;Hunt, Parr, Taylor & Trott, 1963;Sass Kortsak, 1965;Leeson & Fourman, 1967;Smallwood, Williams, Rosenoer & Sherlock, 1968;Worwood, Taylor & Hunt, 1968). Thus a study of the handling of radioactive copper by patients with primary biliary cirrhosis should help to clarify the role of an expanded liver pool of copper on the rate of radioactive copper incorporation into caeruloplasmin.…”

mentioning

confidence: 99%

Studies with Radioactive Copper (64Cu and 67Cu); The Incorporation of Radioactive Copper into Caeruloplasmin in Wilson's Disease and in Primary Biliary Cirrhosis

Gibbs

Walshe

1971

Clinical Science

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1. A comparison has been made of the handling of radioactive copper by patients with Wilson's disease, patients with primary biliary cirrhosis and a small control group. The object of this study has been to assess the influence of an expanded hepatic pool of copper on the incorporation of radioactive copper into caeruloplasmin. 2. Studies with 67Cu have shown that radioactivity disappears steadily from the plasma of patients with Wilson's disease for periods up to 296 h. Both in patients with primary biliary cirrhosis and in controls, a well-marked secondary rise occurs as radioactive copper is incorporated into caeruloplasmin. 3. Caeruloplasmin has been isolated from the serum of one control subject, one patient with primary biliary cirrhosis and one with Wilson's disease. Of the plasma radioactivity 90% was present in the caeruloplasmin of the control subject and the patient with primary biliary cirrhosis; only 27% was found in the caeruloplasmin of the patient with Wilson's disease. 4. Turnover time for liver copper has been determined; in the control subjects it was of the order of 20–30 days, in the patients with primary biliary cirrhosis it was between 600 and 700 days, in Wilson's disease the time exceeded 1800 days. In all cases the turnover time for radioactive copper was significantly less. 5. We conclude (a) that newly arrived radioactive copper is preferentially handled in the presence of copper overload and (b) dilution of radioactive copper in an expanded hepatic pool of the metal cannot alone account for the delayed incorporation found in patients with Wilson's disease.

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confidence: 99%

Studies with Radioactive Copper (64Cu and 67Cu); The Incorporation of Radioactive Copper into Caeruloplasmin in Wilson's Disease and in Primary Biliary Cirrhosis

Gibbs

Walshe

1971

Clinical Science

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“…The copper content of the urine and serum was determined by Giorgio et al's method3 and that of the liver and stools by the wet ashing method of Gubler et al 4 The copper content of the liver, serum and urine was found to be definitely low in our own patient as compared with that of controls (cf. Table 7).…”

mentioning

confidence: 49%

“…Table 3); bone marrow pictures were hypocellular on Oct. 4,1967, and normocellular on Aug. 20, 1968.…”

mentioning

confidence: 99%

Hypocupremic Infant Associated with Mental Retardation and Hepatic Cirrhosis: Probably a Copper Malabsorption Syndrome

Yoshida

Konno

Arakawa

1969

Tohoku J. Exp. Med.

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“…At suboptimal levels of Fe intake, increased supplementation with Cu produces a small increase in haemoglobin level; the same is true of increases in Fe level when Cu intake is suboptimal. T h e mechanism of this interaction is obscure, but it may also apply in the synthesis of the Fe-containing enzyme, catalase, and, if so, would explain earlier controversy about whether Cu deficiency reduces catalase activity (Adams, 1953 ;Gubler, Cartwright & Wintrobe, 1957).…”

Section: The Injuence Of Inorganic Ions In Modifying Trace-element Mementioning

confidence: 99%

Metabolic interrelationships in the utilization of trace elements

Cf¹

1964

Proc. Nutr. Soc.

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The behaviour of the trace elements in biological systems is mostly a reflection of the strong affinity of cellular components for these elements. This behaviour can be modified by changes in the environment of the cell which influence the supply of a particular element available to participate in cellular reactions, by changes which modify cellular components in such a manner that their affinity for the element is increased or decreased, or by changes in the intra-or extra-cellular concentration of elements which compete for a specific binding site. Although in this review we are concerned with nutritional changes that may modify trace-element metabolism in the intact animal we are, in effect, dealing with these reactions. With this in mind I have selected examples of recent advances in knowledge of the influence of the nature of the diet on processes such as the liberation of trace elements from food material, the storage of these elements in the tissues, their incorporation into their functional units in the cell and finally their excretion.

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Studies on Copper Metabolism. XXIII. Portal (Laennec's) Cirrhosis of the Liver1

Cited by 73 publications

References 20 publications

Studies with Radioactive Copper (64Cu and 67Cu); The Incorporation of Radioactive Copper into Caeruloplasmin in Wilson's Disease and in Primary Biliary Cirrhosis

Studies with Radioactive Copper (64Cu and 67Cu); The Incorporation of Radioactive Copper into Caeruloplasmin in Wilson's Disease and in Primary Biliary Cirrhosis

Hypocupremic Infant Associated with Mental Retardation and Hepatic Cirrhosis: Probably a Copper Malabsorption Syndrome

Metabolic interrelationships in the utilization of trace elements

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