Studies on Coumarins of a Chinese Drug „Qian-Hu”

Abstract

From the ether-soluble fraction of methanolic extracts of a Chinese Drug "Bai-Hua Quian-Hu", the root of Peucedanum praeruptorum (Umbelliferae), four coumarin compounds, (+/-) praeruptorin A, (+) praeruptorin B (= (+) anomalin), Pd-III and Pd-Ib, were isolated. The chemical structures of Pd-III and Pd-Ib have been established to be (+) 3' ( S)-angeroyloxy-4' ( S)-isovaleryloxy-3', 4'-dihydroseselin and (+) 3' ( R)-angeroyloxy-4'-keto-3',4'-dihydroseselin, respectively. (13)C NMR spectra of these compounds are also discussed.

Pyranocoumarins from Root Extracts of Peucedanum praeruptorum Dunn with Multidrug Resistance Reversal and Anti-Inflammatory Activities

“…The 15 known compounds were identified as (+)-praeruptorin A (2) [20,21], (+)-praeruptorin B (3) [20,21], (+)-praeruptorin E (4) [20][21][22], selinidin (5) [23], cis-3 1 ,4 1 -diisovalerylkhellactone (6) [19,24], pteryxin (7) [6], suksdorfin (8) [25,26], Pd-Ib (9) [27,28], qianhucoumarin D (10) [20,21], (+)-samidin (11) [25,[29][30][31], laserpitin (12) [33], bergapten (14) [34,35], xanthotoxin (15) [36], and falcalindiol (16) [37][38][39][40].…”

1H and 13C NMR assignments for two new angular furanocoumarin glycosides from Peucedanum praeruptorum

“…The resulting n-butanol extract was chromatographed on silica gel, Sephadex LH-20 gel, followed by semipreparative HPLC to yield peucedanoside A (1), peucedanoside B (2) and apterin (3) (Fig. 1).…”

“…The aqueous layer was further extracted with ethyl acetate (2l) and n-butanol (4l) successively to obtain the EtOAc extract (25 g) and n-butanol extract (20 g). The n-butanol extract was subjected to a silica gel column (200-300 mesh, 200 g) and eluted with a gradient of CHCl 3 …”

“…Each compound (3 mg) was heated in 5 ml of 2 N aqueous CF 3 COOH at 110°C for 6 h in a sealed tube. Then, the reaction mixture was diluted in H 2 O (15 ml) and extracted with EtOAc (5 ml ð 3).…”

Studies of Coumarins from the Chinese Drug Qianhu, XXVII: Structure of a New Simple Coumarin Glycoside from Bai-Hua Qianhu, Peucedanum praeruptorum

“…), and the linear non-glycosidic pyranocoumarins Pd-C-I, Pd-C-II, Pd-C-III, Pd-C-IV, Pd-C-V and AD-I, as well as various saponins, from Zi-Hua Qianhu, the root of P. decursivum MAXIM. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] In addition, we recently isolated two novel angular pyranocoumarin glycosides, peucedanosides A and B, along with apterin 23) and praerosides e and f, 24) from Peucedanum praeruptorum DUNN.…”