Studies on curcumin and curcuminoids. XXII: Curcumin as a reducing agent and as a radical scavenger

Tc̵nnesen, Hanne Hjorth; Greenhill, John V.

doi:10.1016/0378-5173(92)90230-y

Cited by 121 publications

(68 citation statements)

References 9 publications

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“…Curcumin is a known antioxidant and acts as a scavenger of free radicals [21]. Antioxidants such as superoxide dismutase or catalase prevented curcumin induced apoptosis in human leukemia cells [22].…”

Section: Discussionmentioning

confidence: 99%

Antitumor activity of curcumin is mediated through the induction of apoptosis in AK‐5 tumor cells

et al. 1999

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Curcumin, the yellow pigment of turmeric (Curcuma longa), used commonly as a spice, has been shown to possess anticarcinogenic activity. Curcumin inhibited AK-5 tumor growth and induced apoptosis in AK-5 cells. Curcumin induced apoptosis is mediated through the activation of caspase-3, which is specifically inhibited by the tetrapeptide Ac-DEVD-CHO. In addition, curcumin induced tumor cell death is caused through the generation of reactive oxygen intermediates which is inhibited by N-acetyl-L-cysteine. Our studies suggest that the apoptotic process induced by curcumin is the mechanism mediating AK-5 tumor cell death.z 1999 Federation of European Biochemical Societies.

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Section: Discussionmentioning

confidence: 99%

Antitumor activity of curcumin is mediated through the induction of apoptosis in AK‐5 tumor cells

et al. 1999

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“…It was reported that coadministration of antioxidants like superoxide dismutase or catalase prevents curcumin-induced apoptosis in human leukemia cells [6]. On the other hand, curcumin is a known antioxidant and scavenger of free radicals [33]. It also increases the level of glutathione thus preventing thiol depletion occurring typically during apoptosis [34].…”

Section: Discussionmentioning

confidence: 99%

“…To explain this paradox, a broad spectrum of mechanisms have been proposed which include alterations in arachidonate metabolism [7,8], inhibition of protein kinase C [9], and redox regulation [10,Ill. In this paper, we analyzed the primary effects of the presence of CUR in rat thymocytes, and compared the sequence and extent of CUR-evoked events with those occurring during the typical apoptotic program induced by dexamethasone (DEX). The fluorescence and lipophilic properties of CUR [12] provided the basis for the search of its cellular localization and for analyzing the local effects on the structure and function of cellular membranes.…”

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confidence: 99%

Apoptosis‐like, reversible changes in plasma membrane asymmetry and permeability, and transient modifications in mitochondrial membrane potential induced by curcumin in rat thymocytes

et al. 1998

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Curcumin (diferuoylmethane) is a natural compound with anticareinogenic activities which is able to exert either proapoptotic or antiapoptotic effects in different cell types. This paper focuses on the sequence and extent of primary events induced by curcumin, in comparison with those occurring during dexamethasone-induced apoptosis in rat thymocytes. It also presents annexin VI-FITC as a new probe for studying membrane asymmetry. Curcumin readily penetrates into the cytoplasm, and is able to accumulate in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope. Curcumin-treated cells exhibit typical features of apoptotic cell death, including shrinkage, transient phosphatidylserine exposure, increased membrane permeability and decrease in mitochondrial membrane potential. However, nuclei morphology, DNA fragmentation, the extent and time-course of membrane changes are different from those observed during dexamethasone-induced apoptosis, suggesting that, despite many similarities, the mode of action and the events triggered by cnrcumin are different from those occurring during typical apoptosis.© In this paper, we analyzed the primary effects of the presence of CUR in rat thymocytes, and compared the sequence and extent of CUR-evoked events with those occurring during the typical apoptotic program induced by dexamethasone (DEX). The fluorescence and lipophilic properties of CUR [12] provided the basis for the search of its cellular localization and for analyzing the local effects on the structure and function of cellular membranes. Plasma membrane asymmetry was studied by a new fluorescence probe, i.e. annexin VI (Anx VI), isolated from porcine liver and coupled with FITC. We could investigate other parameters such as plasma membrane permeability, mitochondrial membrane potential, as well as other typical apoptotic features ,i.e. changes in cell volume, nucleus morphology and DNA fragmentation. Materials and methods

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“…The protective effect of curcumin on 2,4,6-trinitrobenzene sulfonic-acid-induced colitis in mice has been reported, where curcumin reduced significantly the degree of neutrophil infiltration, lipid peroxidation, and serine protease activity (11). Curcumin is also a potent free radical scavenger having superoxide anions, singlet oxygen, hydroxyl radical scavenging, and lipid peroxidation inhibitory activities (12).…”

Section: Introductionmentioning

confidence: 99%

Effect of Cyclodextrin Complexation of Curcumin on its Solubility and Antiangiogenic and Anti-inflammatory Activity in Rat Colitis Model

et al. 2009

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Abstract. The purpose of the study was to prepare and evaluate the anti-inflammatory activity of cyclodextrin (CD) complex of curcumin for the treatment of inflammatory bowel disease (IBD) in colitisinduced rat model. Inclusion complexes of curcumin were prepared by common solvent and kneading methods. These complexes were further evaluated for increase in solubility of poorly soluble curcumin. The inclusion complexes were characterized for enhancement in solubility, in vitro dissolution, surface morphology, infrared, differential scanning calorimetry, and X-ray studies. Solubility, phase solubility, and in vitro dissolution studies showed that curcumin has higher affinity for hydroxypropyl-β-CD (HPβCD) than other CDs. HPβCD complex of curcumin was further investigated for its antiangiogenic and anti-inflammatory activity using chick embryo and rat colitis model. HPβCD complex of curcumin proved to be a potent angioinhibitory compound, as demonstrated by inhibition of angiogenesis in chorioallantoic membrane assay. Curcumin-and HPβCD-treated rats showed a faster weight gain compared to dextran sulfate solution (DSS) controls. Whole colon length appeared to be significantly longer in HPβCD-treated rats than pure curcumin and DSS controls. An additional finding in the DSStreated rats was the predominance of eosinophils in the chronic cell infiltrate. Decreased mast cell numbers in the mucosa of the colon of CD of curcumin-and pure-curcumin-treated rats was observed. This study concluded that the degree of colitis caused by administration of DSS was significantly attenuated by CD of curcumin. Being a nontoxic natural dietary product, curcumin could be useful in the therapeutic strategy for IBD patients.

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Studies on curcumin and curcuminoids. XXII: Curcumin as a reducing agent and as a radical scavenger

Cited by 121 publications

References 9 publications

Antitumor activity of curcumin is mediated through the induction of apoptosis in AK‐5 tumor cells

Antitumor activity of curcumin is mediated through the induction of apoptosis in AK‐5 tumor cells

Apoptosis‐like, reversible changes in plasma membrane asymmetry and permeability, and transient modifications in mitochondrial membrane potential induced by curcumin in rat thymocytes

Effect of Cyclodextrin Complexation of Curcumin on its Solubility and Antiangiogenic and Anti-inflammatory Activity in Rat Colitis Model

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