Studies on cytokines related to wound healing in donor site wound fluid

Ono, Isao; Gunji, Hironori; Zhang, Jian-Zong; Maruyama, Kohji; Kaneko, Fumio

doi:10.1016/0923-1811(95)00454-z

Cited by 92 publications

(62 citation statements)

References 24 publications

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“…The same cytokines and growth factors have also been reported in wound fluids (Ono et al, 1995;Angel and Szabowski, 2002). Our results are in accordance to these literature as the proinflammatory cytokines IL-6, IL-8, and MCP-1 were found most abundant, showing a mean concentration of >20,000 pg/ml.…”

Section: Cell Proliferationsupporting

confidence: 92%

Wound healing revised: A novel reepithelialization mechanism revealed by in vitro and in silico models

Safferling¹,

Sütterlin²,

Westphal³

et al. 2013

J Exp Med

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Section: Cell Proliferationsupporting

confidence: 92%

Wound healing revised: A novel reepithelialization mechanism revealed by in vitro and in silico models

Safferling¹,

Sütterlin²,

Westphal³

et al. 2013

J Exp Med

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“…This combination of different cellular sources and temporary storage ensures a continuous supply of TGF-␤ throughout the repair process (228). Several publications report on the presence of TGF-␤s in wound fluid of different species (27,35,204,281). Furthermore, expression of all three isoforms was detected in many different cell types during repair, with each isoform having a characteristic distribution in the wound tissue (91,141,157,238,270,271).…”

Section: A Expression Of Tgf-␤ At the Wound Sitementioning

confidence: 99%

Regulation of Wound Healing by Growth Factors and Cytokines

Werner

Grose

2003

Physiological Reviews

3,062

2,082

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Werner, Sabine, and Richard Grose. Regulation of Wound Healing by Growth Factors and Cytokines. Physiol Rev 83: 835–870, 2003; 10.1152/physrev.00032.2002.—Cutaneous wound healing is a complex process involving blood clotting, inflammation, new tissue formation, and finally tissue remodeling. It is well described at the histological level, but the genes that regulate skin repair have only partially been identified. Many experimental and clinical studies have demonstrated varied, but in most cases beneficial, effects of exogenous growth factors on the healing process. However, the roles played by endogenous growth factors have remained largely unclear. Initial approaches at addressing this question focused on the expression analysis of various growth factors, cytokines, and their receptors in different wound models, with first functional data being obtained by applying neutralizing antibodies to wounds. During the past few years, the availability of genetically modified mice has allowed elucidation of the function of various genes in the healing process, and these studies have shed light onto the role of growth factors, cytokines, and their downstream effectors in wound repair. This review summarizes the results of expression studies that have been performed in rodents, pigs, and humans to localize growth factors and their receptors in skin wounds. Most importantly, we also report on genetic studies addressing the functions of endogenous growth factors in the wound repair process.

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“…PDGF, on the other hand, is not produced for autocrine growth because the melanoma cells do not express the PDGF b receptor (Westermark et al, 1986;Forsberg et al, 1993). Besides its mitogenic activity, (Ono et al, 1995;Pierce et al, 1995). Furthermore, PDGF-activated fibroblasts produce IGF-I for stimulation of the malignant cells, which express the IGF-1 receptor .…”

Section: Melanoma-stromal Fibroblast Interactions By Soluble Factorsmentioning

confidence: 99%

Function and regulation of melanoma–stromal fibroblast interactions: when seeds meet soil

et al. 2003

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Melanoma development and progression not only involve genetic and epigenetic changes that take place within the melanocytic cells, but also involve processes that are determined collectively by contextual factors including intercellular adhesions and communications. In this review, we focus on melanoma-stromal fibroblast crosstalk by direct cell-cell contact and by growth factors/ cytokines/chemokines interacting with their respective receptors. The interactions between melanoma cells and stromal fibroblasts create a context that promotes tumor growth, migration/invasion, and angiogenesis. An understanding of this process and developing new experimental and screening models are of great importance for the development of effective therapeutical strategies to treat melanoma.

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Studies on cytokines related to wound healing in donor site wound fluid

Cited by 92 publications

References 24 publications

Wound healing revised: A novel reepithelialization mechanism revealed by in vitro and in silico models

Wound healing revised: A novel reepithelialization mechanism revealed by in vitro and in silico models

Regulation of Wound Healing by Growth Factors and Cytokines

Function and regulation of melanoma–stromal fibroblast interactions: when seeds meet soil

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