Studies on ddt in the depot fat of sheep

Harrison, Dorothy L.; Shanks, V.

doi:10.1080/00288233.1965.10422355

Cited by 4 publications

(5 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, there was more variation among tissues at the beginning of the 7-week depletion period as compared to the end of this period. More consistent results might have been obtained if lower levels of DDT were administered as in the work of Harrison and Shanks (1965) and Carter et al ( 1948). An important point shown by these data is that caudal fat, fat deposited at the base of the tail, was as representative of the total residue concentration as the other sample sites.…”

Section: Resultssupporting

confidence: 53%

“…King et al (1966) reported that a higher amount of heptachlor epoxide tended to accumulate in the ether extract from hide and hair and the liver of a lactating dairy cow, although a uniform distribution of this residue was found among other tissues. Harrison and Shanks (1965) found small but consistent differences in the DDT residue content of omental, peri-renal, and back fat of sheep, and Carter et al (1948) reported a possible difference between the DDT residue content of leaf and back fat of swine.…”

Section: Residuesmentioning

confidence: 90%

See 1 more Smart Citation

Distribution of p,p'-DDT residues in adipose and muscle tissues of beef cattle

Rumsey¹,

Putnam²,

Davis³

et al. 1967

J. Agric. Food Chem.

View full text Add to dashboard Cite

Two groups of beef cattle, consisting of two steers and one cow per group, received a total dose of 300 mg. of p,p'-DDT per kg. of body weight over either a 3or 30-day period. One steer from each group was sacrificed before a 7-week depletion period which followed the treatments. The remaining animals were sacrificed at the end of 7 weeks of de-pletion. Total DDT residues (DDT, DDD, and DDE) appeared on the average to be evenly dis-tributed throughout the extractable fat of beef cattle, based on samples of 13 different tissues. Differences were found in the total DDT residue content of extractable fat due to dose rate (P < 0.01) and time after treatment (P < 0.01), and the relative amounts of DDT, DDD, and DDE were different (P < 0.05) between depot fat, muscle, blood, and milk fat.

show abstract

Section: Resultssupporting

confidence: 53%

Section: Residuesmentioning

confidence: 90%

Distribution of p,p'-DDT residues in adipose and muscle tissues of beef cattle

Rumsey¹,

Putnam²,

Davis³

et al. 1967

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…Levels of the three compounds in blood remained fairly constant from 14 days after dosing had ceased, indicating that equilibrium between the blood and other tissues had become established by about that time. Harrison and Shanks (1965) reported that DDT residues attained maximum levels in sheep fat about 2 weeks after sheep were exposed to a single oral dose of DDT or to DDT in the feed. These data support the suggestion by Schafer (1968) that blood levels of dieldrin (and DDT) probably reflect bot~ the initial absorption of these chemicals and their redistribution in vivo in favour of the fat.…”

Section: Discussionmentioning

confidence: 99%

Metabolism of DDE, DDD, and DDT in sheep

Hunnego¹,

Harrison²

1971

New Zealand Journal of Agricultural Research

Self Cite

View full text Add to dashboard Cite

Sheep were dosed orally for 28 consecutive days with DDE, DDD, or DDT individually, or with a mixture of these three compounds. In a second similar trial DDE was administered either alone or simultaneously with DDD and/or DDT. The dose rate for each compound in all cases was 1 mg pp'-isomer/kg body weight/day. All sheep were sampled for blood and omental fat during the dosing period and the following year.Maximum concentrations determined in fat were in the order DDE > DDD > DDT in the approximate ratios 10: 2: 1. Rates of elimination from fat when dosing was stopped were in the order DDD >DDT >DDE, the half-life being 4, 9, and 14 weeks respectively. In fat, DDE appeared as a metabolite of DDD and DDT, and DDD as a metalobite of DDT. In the first trial the simultaneous administration of DDD and DDT with DDE appeared to stimulate the subsequent elimination of DDE from storage in fat, but this effect was not reproduced in the second trial. There was a correlation between DDE in fat (mg/kg = x) and DDE in whole blood (/Lg/kg = y) expressed by the regression equation.x = 1.8y-l.l A sheep was given one oral dose of DDE, DDD, and DDT simultaneously, each at the rate of 50 mg/kg body weight. Highest concentrations of DDT and DDE occurred in blood 15 hours and 32 hours respectively after dosing. DDD showed two maxima, at 8 hours and at 32 hours after dosing.The value of blood and fat analyses for diagnostic purposes is discussed in relation to the results of these trials.

show abstract

“…In more recent trials, the DDT residue content among depot fat tissues differed significantly (T. S. Rumsey, unpublished data). Small differences in DDT content of depot fat tissues have been suggested in trials with sheep (Harrison and Shanks, 1965) and swine (Carter et al, 1948). There are little data reported concerning the influence that nutritional regimen may have on the concentration of aldrin and dieldrin residues in finished cattle, although Stoewsand and Bourke (1968) have shown that the level of dietary protein influences the storage of dieldrin in rats.…”

mentioning

confidence: 98%