Studies on effect of pH on cross-linking of chitosan with sodium tripolyphosphate: A technical note

Bhumkar, Devika R.; Pokharkar, Varsha

doi:10.1208/pt070250

Cited by 374 publications

(284 citation statements)

References 15 publications

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“…On addition of sodium alginate, the protonated amino groups of chitosan interact with -OR groups provided by sodium alginate. The hydroxyl ions are ionically bonded to the amino groups, which causes deprotonation of amino groups (Bhumkar and Pokharkar 2006). This leaves negatively charged phosphoric ions, which have not been utilized for neutralization of positive charge on chitosan, to provide a net negative charge on to the particles.…”

Section: Morphological Characterizationmentioning

confidence: 99%

“…This further confirms the cross-linking of sodium alginate with chitosan in the formulation. The cross linking between the sodium alginate and chitosan molecule happens either by deprotonation or ionic cross linking (Bhumkar and Pokharkar 2006). In the process of deprotonation, there is a formation of hydrogen bonds between the positively charged amino groups of chitosan and negatively charged hydroxyl groups donated by sodium alginate.…”

Section: Ftir Spectroscopymentioning

confidence: 99%

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Development and optimization of ifosfamide nanostructured lipid carriers for oral delivery using response surface methodology

Velmurugan

Selvamuthukumar

2015

Appl Nanosci

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The research focuses on the development and optimization of ifosfamide nanostructured lipid carriers for oral delivery with the application of response surface methodology. The objectives of the study were to develop a formulation for ifosfamide to be delivered orally, overcome the instability of the drug in acidic environment during oral administration, to sustain the release, drug leakage during storage and low loading capacity. A modified solvent diffusion method in aqueous system was applied to prepare nanostructured lipid nanoparticles. Hydrophilic polymers such as chitosan and sodium alginate were used as coating materials. Glycerol mono oleate and oleic acid were used as solid and liquid lipid, respectively. Poloxamer is used as stabilizers. The central composite rotatable design consisting of three-factored factorial design with three levels was used in this study. The physiochemical characterization included evaluation of surface morphology, particle size and surface charge of the drug in the delivery system. The in vitro drug release, entrapment and drug loading efficiency and as well as the storage stability were evaluated. The results showed that the optimal formulation was composed of drug/lipid ratio of 1:3, organic/aqueous phase ratio of 1:10 and concentration of surfactant of 1 % w/v. Ifosfamide nanostructured lipid carrier under the optimized conditions gave rise to the entrapment efficiency of 77 %, drug loading of 6.14 %, mean diameter of 223 nm and zeta potential value of -25 mV. Transmission electron microscopy analysis showed spherical particles. The in vitro experiment proved that ifosfamide from the delivery system released gradually over the period of 72 h. Sodium alginate cross-linked chitosan nanostructured lipid carrier demonstrated enhanced stability of ifosfamide, high entrapment efficiency and sustained release.

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Section: Morphological Characterizationmentioning

confidence: 99%

Section: Ftir Spectroscopymentioning

confidence: 99%

Development and optimization of ifosfamide nanostructured lipid carriers for oral delivery using response surface methodology

Velmurugan

Selvamuthukumar

2015

Appl Nanosci

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“…These results might cause by a chitosan-TPP contains-NH2 group which in the acidic conditions can be protonated into NH3 + . Furthermore, because of this condition, made the chitosan became more hydrophilic, thus the chitosan-TPP could swell in the acidic medium [16].…”

Section: Swelling Testmentioning

confidence: 99%

Raditya Iswandana, Kurnia Sari Setio Putri, Randika Dwiputra, Tryas Yanuari, Santi Purna Sari, Joshita Djajadisastra

et al. 2017

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Objective: Drug delivery to the colon via oral route can be directly treated a variety of diseases in the colon, such as fibrosis. Tetrandrine is a drug that has anti-fibrosis effects. In this study, chitosan-tripolyphosphate (TPP) beads containing tetrandrine was made and evaluated for in vitro release profile and in vivo targeted test.Methods: Chitosan-TPP tetrandrine beads were prepared by ionic gelation method with variation in sodium tripolyphosphate concentration: 3% (Formula 1), 4% (Formula 2), and 5% (Formula 3). All formulae were characterized for its morphology, particle size, moisture content, process efficiency, entrapment efficiency, thermal character, crystallinity, and swelling. Then, the best formula was coated with HPMCP HP-55, CAP, Eudragit L100-55, or Eudragit L100 prior to drug release profile in vitro and in vivo test. Results:Beads from all formulae had an average size: 920.50±0.04 µm, 942.21±0.08 µm, and 1085.95±0.03 µm; Water content: 7.28±0.003%, 5.64±0.005%, and 6.84±0.004%; Process efficiency: 29.70%, 28.96%, and 29.70%; Entrapment efficiency: 16.20±0.63%, 17.02±0.37%, and 20.42±0.70% for Formula 1, 2, and 3, respectively. In addition, the results of in vitro cumulative drug release were 67. 36%, 76.04%, 83.12%, 83.21%, 40.16%, 37.98%, 45.86%, 41.71% for Formula 3A-3H, respectively. Conclusion:It can be concluded that Formula 3D (CAP 15%) was chosen as a formulation with the best in vitro profile. Moreover, the in vivo targeted test showed that Formula 3D was able to deliver the beads to the intestine compared to the control beads.

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“…The release of DFNa from the composite beads of each formulation was assayed under a simulated gastrointestinal condition by an alternating pH scheme (4,31). A dissolution media of pH 1.2 (0.1 M HCl) was chosen to represent the gastric condition, while pH 6.8 was used to simulate the duodenal condition, and pH 7.4 for the jejunum and ileum.…”

Section: In Vitro Release Studymentioning

confidence: 99%

Chitosan/Polyethylene Glycol Beads Crosslinked with Tripolyphosphate and Glutaraldehyde for Gastrointestinal Drug Delivery

2010

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Abstract. This study reports on the preparation of chitosan (CS)/polyethylene glycol (PEG) hydrogel beads using sodium diclofenac (DFNa) as a model drug. Following the optimization of the polymer to drug ratio, the chitosan beads were modified by ionic crosslinking with sodium tripolyphosphate (TPP). The CS/PEG/DFNa beads obtained from a (w/w/w) ratio of 1/0.5/0.5 with crosslinking in 10% (w/v) TPP at pH 6.0 for 30 min yielded excellent DFNa encapsulation levels with over 90% loading efficiency. The dissolution profile of DFNa from CS/PEG/DFNa beads demonstrated that this formulation was able to maintain a prolonged drug release for approximately 8 h. Among the formulations tested, the CS/PEG/ DFNa (1/0.5/1 (w/w/w)) beads crosslinked with a combination of TPP (10% (w/v) for 30 min) and glutaraldehyde (GD) (5% (w/v)) were able to provide minimal DFNa release in the gastric and duodenal simulated fluids (pH 1.2 and 6.8, respectively) allowing for a principally gradual drug release over 24 h in the intestinal (jejunum and ileum) simulated fluid (pH 7.4). Thus, overall the CS/PEG beads crosslinked with TPP and GD look to be a promising and novel alternative gastrointestinal drug release system.

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Studies on effect of pH on cross-linking of chitosan with sodium tripolyphosphate: A technical note

Abstract: Preparation of cross-linked chitosan Chitosan (60 mg) was dissolved in 20 mL acetic acid (2% vol/vol) to obtain chitosan solution. TPP (0.1%) was added to chitosan solution with mild stirring until an opalescent

Cited by 374 publications

References 15 publications

Development and optimization of ifosfamide nanostructured lipid carriers for oral delivery using response surface methodology

Development and optimization of ifosfamide nanostructured lipid carriers for oral delivery using response surface methodology

Raditya Iswandana, Kurnia Sari Setio Putri, Randika Dwiputra, Tryas Yanuari, Santi Purna Sari, Joshita Djajadisastra

Chitosan/Polyethylene Glycol Beads Crosslinked with Tripolyphosphate and Glutaraldehyde for Gastrointestinal Drug Delivery

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