Studies on effect of Tongfengxiaofang in HUM model mice using a UPLC–ESI–Q‐TOF/MS metabolomic approach

Chen, Renhao; Wang, Qi; Li, Zhifeng; Wang, Dongxu; Yang, Shilin; Feng, Yulin

doi:10.1002/bmc.5118

Cited by 5 publications

(3 citation statements)

References 56 publications

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“…Another similar study investigated a mouse model of hyperuricemia by metabolomics. Chen et al (2021b) presented that Tongfengxiaofang could regulate various disorders of arginine biosynthesis, galactose metabolism, pyrimidine metabolism, glycerophospholipid metabolism, tryptophan metabolism, and TCA cycle caused by hyperuricemia. The potential molecular mechanisms of anti-hyperuricemia in other herbs, such as QZTBD, EMW, and chicory, have also been reported ( Chen et al, 2016 ; Bian et al, 2018 ; Huang et al, 2019 ).…”

Section: Survey Methodologymentioning

confidence: 99%

The biomarkers discovery of hyperuricemia and gout: proteomics and metabolomics

You

2022

PeerJ

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Background Hyperuricemia and gout are a group of disorders of purine metabolism. In recent years, the incidence of hyperuricemia and gout has been increasing, which is a severe threat to people’s health. Several studies on hyperuricemia and gout in proteomics and metabolomics have been conducted recently. Some literature has identified biomarkers that distinguish asymptomatic hyperuricemia from acute gout or remission of gout. We summarize the physiological processes in which these biomarkers may be involved and their role in disease progression. Methodology We used professional databases including PubMed, Web of Science to conduct the literature review. This review addresses the current landscape of hyperuricemia and gout biomarkers with a focus on proteomics and metabolomics. Results Proteomic methods are used to identify differentially expressed proteins to find specific biomarkers. These findings may be suggestive for the diagnosis and treatment of hyperuricemia and gout to explore the disease pathogenesis. The identified biomarkers may be mediators of the link between hyperuricemia, gout and kidney disease, metabolic syndrome, diabetes and hypertriglyceridemia. Metabolomics reveals the main influential pathways through small molecule metabolites, such as amino acid metabolism, lipid metabolism, or other characteristic metabolic pathways. These studies have contributed to the discovery of Chinese medicine. Some traditional Chinese medicine compounds can improve the metabolic disorders of the disease. Conclusions We suggest some possible relationships of potential biomarkers with inflammatory episodes, complement activation, and metabolic pathways. These biomarkers are able to distinguish between different stages of disease development. However, there are relatively few proteomic as well as metabolomic studies on hyperuricemia and gout, and some experiments are only primary screening tests, which need further in-depth study.

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Section: Survey Methodologymentioning

confidence: 99%

The biomarkers discovery of hyperuricemia and gout: proteomics and metabolomics

You

2022

PeerJ

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“…In this study, feeding HMEC did not result in any significant alterations in serum TG levels, implying the absence of adverse effects on lipid metabolism in dairy cows. Creatinine and urea serve as indicators of renal function [32]. Creatinine is primarily eliminated through glomerular filtration, and its levels predominantly reflect the glomerular filtration capacity [33].…”

Section: Discussionmentioning

confidence: 99%

Impact of High-Moisture Ear Corn on Antioxidant Capacity, Immunity, Rumen Fermentation, and Microbial Diversity in Pluriparous Dairy Cows

Shang,

Li,

Zhang

et al. 2024

Fermentation

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Due to the increasing costs of livestock farming, it is important to find cost-effective alternatives of feed stuffs. This study investigated the effects of high-moisture ear corn (HMEC) feeding on the production performance, serum antioxidant capacity, immunity, and ruminal fermentation and microbiome of dairy cows. Thirty pluriparous Chinese Holstein cows were randomly allocated to two groups: steam-flaked corn (SFC) and HMEC (replacement of 2 kg equal dry matter SFC) and fed for a 60 day trial. The results showed replacing SFC with HMEC significantly increased dry matter intake, milk yield, and 4% fat-corrected milk yield (p < 0.05). Serum levels of superoxide dismutase, glutathione peroxidase, and immunoglobulins G, M, and A were significantly higher, and those of creatinine and cholesterol were significantly lower, in the HMEC group than in the SFC group (p < 0.05). HMEC also significantly increased total volatile fatty acid and acetate (p < 0.05) concentrations. In both groups, the dominant phyla of ruminal bacteria were Bacteroidetes, Firmicutes, and Actinobacteria, and the dominant genera were Prevotella, NK4A214-group, and Succiniclasticum. Mogibacterium, Eubacterium nodatum group, norank-f-Lachnospiraceae, and Eubacterium brachy group were significantly enriched in the ruminal fluid of HMEC-group cows (p < 0.05). In conclusion, replacing SFC with HMEC improved production performance, antioxidant capacity, and immunity, while regulating both ruminal fermentation and the composition of the ruminal microbiome in dairy cows.

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“…These remarkably altered metabolites could be divided into a few main classes, such as amino acids and their metabolites, organic acids and their derivatives, fatty acids, nucleotides and their metabolites, benzene and substituted derivatives, and carbohydrates and their metabolites. Previous studies reported that HUA-induced CKD is usually accompanied by metabolic disorder, especially with respect to the metabolism of lipids, amino acids, and carbohydrates [44][45] . As shown in Fig.…”

Section: Effects Of Adbp On the Kidney Metabolome Of Huainduced Ckd Micementioning

confidence: 99%

Andrias davidianus bone peptides alleviates hyperuricemia-induced kidney damage in vitro and in vivo

Li,

Chen,

Chen

et al. 2024

Food Science and Human Wellness

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Hyperuricemia (HUA) is a vital risk factor for chronic kidney diseases (CKD) and development of functional foods capable of protecting CKD is of importance. This paper aimed to explore the amelioration effects and mechanism of Andrias davidianus bone peptides (ADBP) on HUA-induced kidney damage. In the present study, we generated the standard ADBP which contained high hydrophobic amino acid and low molecular peptide contents. In vitro results found that ADBP protected uric acid (UA)-induced HK-2 cells from damage by modulating urate transporters and antioxidant defense. In vivo results indicated that ADBP effectively ameliorated renal injury in HUA-induced CKD mice, evidenced by a remarkable decrease in serum UA, creatinine and blood urea nitrogen, improving kidney UA excretion, antioxidant defense and histological kidney deterioration. Metabolomic analysis highlighted 14 metabolites that could be selected as potential biomarkers and attributed to the amelioration effects of ADBP on CKD mice kidney dysfunction. Intriguingly, ADBP restored the gut microbiome homeostasis in CKD mice, especially with respect to the elevated helpful microbial abundance, and the decreased harmful bacterial abundance. This study demonstrated that ADBP displayed great nephroprotective effects, and has great promise as a food or functional food ingredient for the prevention and treatment of HUA-induced CKD.

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Studies on effect of Tongfengxiaofang in HUM model mice using a UPLC–ESI–Q‐TOF/MS metabolomic approach

Cited by 5 publications

References 56 publications

The biomarkers discovery of hyperuricemia and gout: proteomics and metabolomics

The biomarkers discovery of hyperuricemia and gout: proteomics and metabolomics

Impact of High-Moisture Ear Corn on Antioxidant Capacity, Immunity, Rumen Fermentation, and Microbial Diversity in Pluriparous Dairy Cows

Andrias davidianus bone peptides alleviates hyperuricemia-induced kidney damage in vitro and in vivo

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