Studies on Enaminonitriles: A New Synthesis of 1,3‐Substituted Pyrazole‐4‐carbonitrile.

Chitosan as heterogeneous catalyst in Michael additions: The reaction of cinnamonitriles with active methyls, active methylenes and phenols

“…Again similar to reported formation of 13a-c from reactions of 12a-c with 1 in pyridine (67, 61 and 76% yields respectively), 42 compounds 12a-c reacted with 1 in ethanol in the presence of chitosan to afford 13a-c with 65%, 55% and 71 % yields respectively (Scheme 4). The reaction of 2-amino-1-propene-1,1,3-tricarbonitrile 18 with 1 gave the addition product 20 in ethanol in presence of chitosan (63% yield).…”

Chitosan as a green catalyst for synthesis of pyridazines and fused pyridazines via [3+3] atom combination with arylhydrazones as 3 atom components

“…In conjunction to our interest in developing syntheses for biologically interesting pyridazines, [10][11][12] we investigated the Michael addition reaction of pyruvaldehyde-1-arylhydrazones 1a-c towards α,β-unsaturated nitriles 2a-e. In previous recent articles 11,12 we investigated the first reported synthesis of pyridazines from arylhydrazones via 3+3 atom combination.…”

“…In previous recent articles 11,12 we investigated the first reported synthesis of pyridazines from arylhydrazones via 3+3 atom combination. In this article we extend our investigation utilizing different substituted cinnamonitriles to prepare pyridazines which can be used as precursors to functionally substituted fused pyridazines.…”

Multicomponent reactions under increased pressure: on the reaction of arylhydrazonals, aromatic aldehydes and malononitrile in Q-Tube

“…Our first achievement in this area utilizing Q-tube as safe pressure reactor to enhance conducting reactions under high pressure in laboratory has very recently been reported [11,12]. In the present article, we report results of our investigation on the reported 3+3 atom combination for the synthesis of pyridazines and condensed pyridazines [13][14][15], under increased pressure. The work enabled defining the scope of this synthesis and enabled disclosing novel routes to naphthyridine, pyridazine and biphenyl derivatives.…”