Studies on encapsulation of Rifampicin and its release from chitosan-dextran sulfate capsules

Devi, M. Geetha; Dutta, Susmita; Hinai, Ashraf Talib Al; Shaik, Feroz

doi:10.1007/s11814-014-0161-9

Cited by 17 publications

(11 citation statements)

References 38 publications

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“…CaCO3 nanoparticles have gained considerable attention due to their excellent biocompatibility, thermal stability, and low toxicity, and facile synthesis methods. Nanoparticle mediated treatment techniques are superior due to its performance characteristics at different processing conditions [7][8][9][10][11].Nanoparticles possess distinctive properties owing to their extremely small size and exceptional surface area per unit volume; thus, they demonstrate a higher reactivity with other molecules [12].Treatment of a highly concentrated textile effluent was carried out using calcium carbonate [13]. Most of the studies focused on the usage of expensive materials in excess quantities and toxic chemicals used in the processing stages restricts such treatment systems.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Calcium Carbonate Nanoparticles and its Application in Grey Water Treatment

Al-Lezami

Devi²

2022

IOP Conf. Ser.: Earth Environ. Sci.

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Nanotechnology is one of the emerging technologies with unique functionalities and great potential in the removal of pollutants from waste water. Nanoparticle mediated waste water treatment is a promising alternative to traditional water treatment techniques. Considerable amount of grey water is thrown out of the household activities on a daily basis, which in turn lead to environmental pollution in the long run and hence results in increased fresh water consumption. The present study focused on the synthesis of calcium carbonate nanoparticles using homogenisation process for the treatment of grey water. The nanoparticles were characterised using Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), and X-Ray Diffraction (XRD). The synthesised nanoparticles were employed in the batch treatment of grey water by varying the solution pH, stirring time; stirring speed and dosage of calcium carbonate nanoparticles. The pollutant removal efficiency of the nanoparticles were assessed by measuring the Chemical Oxygen demand (COD), Total Suspended solids (TDS), Total dissolved solids (TDS), Dissolved oxygen (DO) and turbidity. The study demonstrates that the optimum pollutant removal efficiency was obtained at pH 8.0, stirring speed of 100 rpm, mixing time of 75 minutes and 0.7 g dosage of calcium carbonate nanoparticles. The maximum reduction in COD at optimum processing condition was 78%. The outcome of the study suggests that calcium carbonate nanoparticle could effectively remove pollutants from grey water. This research is in line with the United Nations Sustainable Development Goals (UNSD), which is clean water and sanitation. This community engagement project will serve the society by saving the water and to produce a clean environment.

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Section: Introductionmentioning

confidence: 99%

Synthesis of Calcium Carbonate Nanoparticles and its Application in Grey Water Treatment

Al-Lezami

Devi²

2022

IOP Conf. Ser.: Earth Environ. Sci.

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“…Anti-tuberculosis drug, rifampicin encapsulated into prepared hollow capsules. The microcapsules exhibited sustained release of rifampicin over 72 hours at pH=1.2 and pH=7.4 [12].…”

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confidence: 99%

“…Recently, the possibilities of different drug delivery systems usage (DDS) for antituberculosis drugs has been studied more: polymeric composites, microparticles, nanoparticles, liposomes, the hollow and filled capsules [2][3][4][5][6][7][8][9][10][11][12]. As a model of antituberculosis drug rifampicin has been more studied [5][6][7][8][11][12].…”

mentioning

confidence: 99%

“…В последнее время изучены возмож-ности использования различных систем доставки для создания противотуберку-лезных лекарственных препаратов: по-лимерные композиты, микрочастицы, наночастицы, липосомы, заполненные и полые капсулы [2][3][4][5][6][7][8][9][10][11][12]. В большинстве случаев в качестве модели рассматривал-ся рифампицин [5][6][7][8][11][12].…”

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“…Имеются данные по микрокапсулированию проти-вотуберкулезных лекарственных препара-тов полиэлектролитными мультислоями LbL (техника слой за слоем). С помощью этой технологии были получены хито-зан-декстрансульфатные микрокапсулы с рифампицином с использованием диокси-да кремния в качестве ядра с высвобожде-нием рифампицина при pH=1,2 и pH=7,4 в течение 72 часов [12].…”

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Encapsulation of Antitubercular Drugs by Biopolymers and Polyelectrolyte Multilayers

Мусабаева¹,

Мурзагулова²,

Ким³

et al. 2017

Farm. farmakol. (Pâtigorsk)

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Sustained release of alpha‐methylacyl‐CoA racemase (AMACR) antibody‐conjugated and free doxorubicin from silica nanoparticles for prostate cancer cell growth inhibition

et al. 2022

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This article presents silica nanoparticles for the sustained release of AMACR antibody-conjugated and free doxorubicin (DOX) for the inhibition of prostate cancer cell growth. Inorganic MCM-41 silica nanoparticles were synthesized, functionalized with phenylboronic acid groups (MCM-B), and capped with dextran (MCM-B-D). The nanoparticles were then characterized using Fourier-transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, zeta potential analysis, nitrogen sorption, X-ray diffraction, and thermogravimetric analysis, before exploring their potential for drug loading and controlled drug release. This was done using a model prostate cancer drug, DOX, and a targeted prostate cancer drug, α-Methyl Acyl-CoA racemase (AMACR) antibody-conjugated DOX, which attaches specifically to AMACR proteins that are overexpressed on the surfaces of prostate cancer cells. The kinetics of sustained drug release over 30 days was then studied using zeroth order, first order, second order, Higuchi, and the Korsmeyer-Peppas models, while the thermodynamics of drug release was elucidated by determining the entropy and enthalpy changes. The flux of the released DOX was also simulated using the COMSOL Multiphysics software package. Generally, the AMACR antibodyconjugated DOX drug-loaded nanoparticles were more effective than the free DOX drug-loaded formulations in inhibiting the growth of prostate cancer cells in vitro over a 96 h period. The implications of the results are then discussed for the development of drug-eluting structures for the localized and targeted treatment of prostate cancer.

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Studies on encapsulation of Rifampicin and its release from chitosan-dextran sulfate capsules

Cited by 17 publications

References 38 publications

Synthesis of Calcium Carbonate Nanoparticles and its Application in Grey Water Treatment

Synthesis of Calcium Carbonate Nanoparticles and its Application in Grey Water Treatment

Encapsulation of Antitubercular Drugs by Biopolymers and Polyelectrolyte Multilayers

Sustained release of alpha‐methylacyl‐CoA racemase (AMACR) antibody‐conjugated and free doxorubicin from silica nanoparticles for prostate cancer cell growth inhibition

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