Studies on Enzymes of Inositol Metabolism

Sherman, William R.; Hipps, Paul P.; Mauck, Linda; Rasheed, A.

doi:10.1016/b978-0-12-741750-9.50025-2

Cited by 9 publications

(12 citation statements)

References 24 publications

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“…The scyllo-inositovmyo-inositol ratios found here resemble those reported for rabbit CNS (Sherman et al, 1968), both in magnitude and uniformity. The uniformity of these ratios within and across regions is consistent with a close metabolic interrelationship of these stereoisomers (Posternak et al, 1963;Sherman et al, 1968Sherman et al, , 1978Hipps et al, 1977).…”

Section: Comparisons With Other Studiessupporting

confidence: 72%

“…scyllo-Inositol is metabolically related t o myo-inositol (Posternak et al, 1963), which it accompanies in many tissues (Sherman et al, 1968). An epimerase has been isolated from bovine brain that transforms rnyot o scyflo-inositol (Hipps e t al., 1977;Sherman et al, 1978). In the present study, myoand scyllo-inositol levels were compared in samples from several parts of the cochlear nucleus as well as other nearby regions.…”

mentioning

confidence: 96%

“…myo-Inositol is both synthesized (Eisenberg, 1967;Mauck et al, 1980) and taken up by transport (Spector and Lorenzo, 1975) in mammalian brain. There are only two known metabolic pathways in brain that utilize myo-inositol: phosphoinositide metabolism (e.g., Michell, 1975;Hawthorne and Pickard, 1979), and the epimerase pathway, which converts myo-to scyllo-and neo-inositol (Hipps et al, 1977;Sherman et al, 1978). Although the functions of scyllo-and neo-inositols are unknown, the phosphoinositides are known to be highly active metabolically in neural as well as in other tissues.…”

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confidence: 99%

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Distribution of myo‐Inositol in the Cat Cochlear Nucleus

Godfrey

Hallcher

Laird

et al. 1982

Journal of Neurochemistry

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The distribution of myo-inositol, a substance that has been implicated in synaptic transmission, has been mapped within sections of the cat cochlear nucleus as well as some nearby regions. Highest values in the cochlear nucleus were found in regions of granule cells along the periphery of the anteroventral subdivision of the nucleus. Highest values overall were found in the molecular layer of the cerebellar flocculus. A fairly good correlation was found between myo-inositol levels and activities of the enzymes of acetylcholine metabolism in the cat cochlear nucleus, supporting the possibility that myo-inositol may be involved in cholinergic synaptic transmission. No positive correlation was found between myo-inositol levels and the levels of glutamate, aspartate, glycine, or gamma-aminobutyric acid (GABA). The most striking gradient of myo-inositol levels within a region was found in the auditory nerve, where different myo-inositol levels might be related to nerve fibers innervating different parts of the cochlea. The distribution of scyllo-inositol, a stereoisomer of myo-inositol, was also examined, and found to parallel closely the distribution of myo-inositol, with levels 4--5% as high.

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Section: Comparisons With Other Studiessupporting

confidence: 72%

mentioning

confidence: 96%

mentioning

confidence: 99%

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Distribution of myo‐Inositol in the Cat Cochlear Nucleus

Godfrey

Hallcher

Laird

et al. 1982

Journal of Neurochemistry

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“…We have now worked out a new mechanism that somewhat differs from that suggested by Floss and his group, but which seems to be in agreement with the data reported by them as well as with those of Sherman et al (24).…”

supporting

confidence: 78%

The biosynthesis of myo-inositol and its isomers

Hoffmann‐Ostenhof¹,

Pittner²

1982

Can. J. Chem.

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The present state of our knowledge about the biosynthetic processes leading to the inositols is reviewed. On the basis of experimental data obtained in the laboratory of the authors and by other groups working on the problem, anew mechanism of action for the mammalian myo-inositol- 1-phosphate synthase is suggested. The central position of myo-inositol in the synthesis of the other inositols is described.

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“…To support the MA approach, it must be noted that mIPS/NAD exchange studies on a mixture of 5- H 2 -G6P/G6P have shown that tightening of the complex occurs in the early stages of the catalysis, with no scrambling of the deuterium atom upon turnover to L-2-H 2 -mIP and L-mIP respectively (figure 1). 14 Therefore, we proposed to generate a class of multisubstrate adducts where the carbohydrate moiety of G6P was to be linked to an aromatic ring incorporated in a nucleosidic linkage with a riboside moiety. Such a molecule would possess the features of the phosphosugar substrate and of the nucleotide cofactor, both required for a multisubstrate type binding to mIPS.…”

Section: Introductionmentioning

confidence: 99%