Studies on Erythropoiesis Inhibiting Factor (EIF)

Studies on an Inhibitor of Erythropoiesis. II. Inhibitory Effects of Serum from Uremic Rabbits on Heme Synthesis in Rabbit Bone Marrow Cultures

“…These findings suggest that toxic effects of metabolic products of uremia on erythroid cells, especially the presence of inhibitor substance(s), are important in the mechanism of the anemia of uremia. A plasma factor capable of inhibiting the in vivo response to ESF has been described by Fisher et al (6) and Moriyama et al (7). In addition we have recently reported the existence of a tissue-specific inhibitor of erythropoiesis in vitro in sera from normal and polycythemic rabbits (8).…”