Studies on experimental Jembrana disease in Bali cattle. III. Pathology

Dharma, D.M.N.; Budiantono, A.; Campbell, R. S. F.; Ladds, P. W.

doi:10.1016/s0021-9975(08)80109-0

Cited by 37 publications

(22 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This provides an explanation for the common occurrence of secondary infections which may lead to fatal issues in affected cattle (Dharma et al, 1991;Teuscher et al, 1982). The finding showed that no recurrence of disease is observed in recovered animals and importantly they resist to further infections for at least 22 months (Dharma et al, 1991;Soeharsono et al, 1990). This suggests that JDV infections induce a protective immunity and probably vaccination using denatured or attenuated viral particles, can be performed to limit the disease spread.…”

Section: Introductionmentioning

confidence: 83%

“…Analyses included determination of the genome copies by real-time RT-PCR as described earlier Kusumawati et al, 2015) and humoral response by Western immunoblot and ELISA using recombinant JDV proteins as previously described . The vaccine efficacy was determined for different parameters as described below Humoral Response JDV-infected cattle frequently succumb to secondary infections (Dharma et al, 1991), resulting from transient immunosuppression characteristic to Jembrana disease (Wareing et al, 1999). In spite of this, vaccinated cattle still develop virus specific antibodies following infection.…”

Section: Jdv Vaccine Efficacymentioning

confidence: 99%

See 1 more Smart Citation

Vaccine against Jembrana Disease Virus Infection: A Summary Findings

Kusumawati¹,

Wanahari²,

Astuti³

et al. 2015

American Journal of Immunology

View full text Add to dashboard Cite

Jembrana disease constitutes the main concern in cattle industry especially in Indonesia and Australia as it has caused important economic losses due to mortality of cattle. The pathology of the disease is unusual for a lentivirus infection as it is associated with a severe, often lethal disease syndrome and a short incubation period in cattle. For lack of efficient medical treatment of JDV-infected cattle, vaccination may therefore constitute an effective measure for the prevention or eradication of Jembrana disease. Up to date, only one type of vaccine has been reported and tested. It is based on inactivated, tissue-derived virus antigens (Tabanan/87 isolate, JDV TAB/87 ). This review summarize show current Jembrana disease vaccine was developed as well as evaluated and how these information might be useful in future vaccine design.

show abstract

Section: Introductionmentioning

confidence: 83%

Section: Jdv Vaccine Efficacymentioning

confidence: 99%

Vaccine against Jembrana Disease Virus Infection: A Summary Findings

Kusumawati¹,

Wanahari²,

Astuti³

et al. 2015

American Journal of Immunology

View full text Add to dashboard Cite

show abstract

“…After a short incubation period of 5-12 days, affected animals show clinical signs of fever, lymphadenopathy and lymphopenia, at which stage high viral titres of 10 s infectious units/ml are found in the plasma (Soeharsono et al, I990;Soesanto et al, 1990). Pathological changes reflect an intense lymphoproliferative disorder affecting most organ systems except the central nervous system (Dharma et al, 1991). Lymphoid tissues of all organs, particularly in the enlarged lymph nodes and spleen, feature proliferating lymphoblastoid cells predominantly throughout parafollicular (T cell) areas, and atrophy of * Author for correspondence.…”

Section: Introductionmentioning

confidence: 99%

“…A proliferative lymphoid infiltrate is also found in the parenchyma of most organs, particularly the liver and kidneys (Dharma et al, 1991) and an infiltrate containing proliferative macrophagelike cells is found in the lungs (Budiarso & Rikihisa, 1992). In fatal infections, death is attributed to multisystem involvement.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Nucleotide sequence analysis of Jembrana disease virus: a bovine lentivirus associated with an acute disease syndrome

Chadwick

Coelen

Wilcox

et al. 1995

Journal of General Virology

View full text Add to dashboard Cite

The complete nucleotide sequence of the RNA genome of Jembrana disease virus (JDV), a lentivirus that causes an acute disease syndrome in Bali cattle (Bosjavanicus), is reported. In addition to the gag, pol and env genes and flanking long terminal repeats (LTRs) that characterize all retroviruses, a number of accessory genes represented by small multiply spliced ORFs in the central and 3'-terminal regions of the genome, including tat and rev that are typical of lentiviruses, were identified. The genome of JDV was 7732 bp in length, 750 bp smaller than the genome of bovine immunodeficiency virus (BIV) strain BIV127. A striking feature of the genome was the many deletions relative to BIV127, the largest of which were 471 bp from the env gene and 157 bp from the U3 (promoter) region in the LTR. There were also several insertions of up to 33 bp in the JDV genome relative to BIV127 found in the env gene and small ORFs that overlap env. Other significant genomic differences between JDV and BIV127 included changes to cis-acting sequences throughout the genome such as promoter and enhancer sequences in the LTR, the trans-activation response region, splice sites and frameshift sequences; alterations to the gag precursor protein cleavage sites and thus the processed products; loss of the vpw and vpy ORFs; and amino acid changes in all coding regions. The significance of these changes is discussed in relation to the differences in pathogenicity between JDV and BIV.

show abstract

Nonprimate Lentiviral Vectors

Nolan

2002

Current Topics in Microbiology and Immunology

View full text Add to dashboard Cite

Studies on experimental Jembrana disease in Bali cattle. III. Pathology

Cited by 37 publications

References 6 publications

Vaccine against Jembrana Disease Virus Infection: A Summary Findings

Vaccine against Jembrana Disease Virus Infection: A Summary Findings

Nucleotide sequence analysis of Jembrana disease virus: a bovine lentivirus associated with an acute disease syndrome

Nonprimate Lentiviral Vectors

Contact Info

Product

Resources

About