Studies on Experimental Rickets.

McCollum, E. V.; Simmonds, Nina; Becker, J. Ernestine; Shipley, P. G.

doi:10.1111/j.1753-4887.1975.tb07097.x

Cited by 9 publications

(7 citation statements)

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“…Reptilian osteoderms, description, demineralization and fine structure Otto (1908); Schmidt (1912); Castanet (1985) 1908 Demineralization of the fish otoliths and isolation of gelatinous organic matrix Immermann (1908); Maier (1908); Lissner (1925Lissner ( ) 1909 ''A History of Dentistry'' is published Prinz (1909Prinz ( ) 1911 Bacterial-chemical study of dental caries Lothrop (1911) Fish scales, demineralization and fine structure, fish scale collagen Cockerell (1911); Waterman (1970); Onozato and Watabe (1979); Schonborner et al (1981); Zylberberg and Meunier (1981); Zylberberg et al (1988Zylberberg et al ( ) 1914 High ingestion of acid-forming foods appeared to cause decalcification Steenbock et al (1914Steenbock et al ( ) 1914 The role of phosphoric esterase in decalcification Bergeim (1914Bergeim ( ) 1915 Kalklösende Algae Bachmann (1915Bachmann ( ) 1920 The origin, growth and fate of osteoclasts and their relation to bone resorption Arey (1920Arey ( ) 1921 Diaphanol (ClO 2 in acetic acid) as demineralizing agent for animal hard tissues Schulze (1921Schulze ( ) 1921 Development of decalcification solutions containing organic solvents Jenkins (1921); Scott andKyffin (1978) 1922 Use of hematoporphyrin for identification of decalcification in bone McCollum et al (1922McCollum et al ( ) 1922 Demineralization of marine invertebrates Clarke andWheeler (1922) 1922 Coral sclerites as biocrystals Schmidt (1922aSchmidt ...…”

Section: Biominerals and Biomineralizationmentioning

confidence: 99%

Principles of demineralization: Modern strategies for the isolation of organic frameworks

Ehrlich

Koutsoukos

Demadis

et al. 2008

Micron

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Section: Biominerals and Biomineralizationmentioning

confidence: 99%

Principles of demineralization: Modern strategies for the isolation of organic frameworks

Ehrlich

Koutsoukos

Demadis

et al. 2008

Micron

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“…In the early 1920s vitamin D was identified as a new essential nutrient in cod-liver oil that cured rickets, a skeletal disorder characterized by undermineralized bones [1]. A few years later the chemical structure of vitamin D was described by the German chemist and Nobel Prize winner Adolf Windaus [2].…”

Section: Introductionmentioning

confidence: 99%

Mechanism and Potential of the Growth-Inhibitory Actions of Vitamin D and Analogs

Eelen

Gysemans²,

Verlinden³

et al. 2007

CMC

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1alpha,25-Dihydroxyvitamin D(3) [1,25-(OH) (2)D(3)] can exert its biological actions through binding with the nuclear vitamin D receptor (VDR), a ligand-activated transcription factor. Next to control of bone and mineral homeostasis, these actions include an immunomodulatory effect and a potent growth-inhibitory, antiproliferative or prodifferentiating action on a wide variety of cell types. The molecular mechanisms underlying this antiproliferative action form an intriguing research topic and they remain, although thoroughly studied, not completely understood. Important cell cycle regulators are involved such as cyclins, cyclin dependent kinases and their corresponding inhibitors as well as E2F transcription factors and accompanying pocket proteins. Whether 1,25-(OH)(2)D(3) influences the expression of all these proteins directly through the nuclear VDR or rather in an indirect manner is not always clear. The antiproliferative action makes 1,25-(OH) (2)D(3) a possible therapeutic tool to treat hyperproliferative disorders, among which different types of cancer. Clinical application, however, is severely hampered by calcemic effects such as hypercalcemia, hypercalciuria and increased bone resorption. Rational design of chemically modified 1,25-(OH) (2)D(3)-analogs tries to overcome this problem. As such, several thousands of analogs have been synthesized and evaluated, some of which display the desired dissociation between beneficial antiproliferative and unwanted calcemic effects. A number of those analogs are 'superagonistic' and have a several-fold stronger antiproliferative action than the parent compound. This review focuses on recent findings about the complex mechanisms behind the antiproliferative and prodifferentiating effect of 1,25-(OH) (2)D(3). Furthermore, the mode of action and possible clinical application of chemically modified 1,25-(OH) (2)D(3)-analogs will be discussed.

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“…Several years later, Sir Edward Mellanby (1921) ascribed the cause of rickets to the deficiency of a fat-soluble vitamin [14]. However, the breakthrough discovery was when McCollum and his associates found that this fat-soluble entity was a dietary supplement and named it Vitamin D [15].…”

Section: Introductionmentioning

confidence: 99%

A Narrative Role of Vitamin D and Its Receptor: With Current Evidence on the Gastric Tissues

Sirajudeen

Shah

Menhali

2019

IJMS

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Vitamin D is a major steroid hormone that is gaining attention as a therapeutic molecule. Due to the general awareness of its importance for the overall well-being, vitamin D deficiency (VDD) is now recognized as a major health issue. The main reason for VDD is minimal exposure to sunlight. The vitamin D receptor (VDR) is a member of the steroid hormone receptors that induces a cascade of cell signaling to maintain healthy Ca2+ levels that serve to regulate several biological functions. However, the roles of vitamin D and its metabolism in maintaining gastric homeostasis have not yet been completely elucidated. Currently, there is a need to increase the vitamin D status in individuals worldwide as it has been shown to improve musculoskeletal health and reduce the risk of chronic illnesses, including some cancers, autoimmune and infectious diseases, type 2 diabetes mellitus, neurocognitive disorders, and general mortality. The role of vitamin D in gastric homeostasis is crucial and unexplored. This review attempts to elucidate the central role of vitamin D in preserving and maintaining the overall health and homeostasis of the stomach tissue.

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Studies on Experimental Rickets.

Cited by 9 publications

References 0 publications

Principles of demineralization: Modern strategies for the isolation of organic frameworks

Principles of demineralization: Modern strategies for the isolation of organic frameworks

Mechanism and Potential of the Growth-Inhibitory Actions of Vitamin D and Analogs

A Narrative Role of Vitamin D and Its Receptor: With Current Evidence on the Gastric Tissues

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