Studies on flower induction and improvement of fruit yield and its attributes in pomegranate (Punica granatum L.) CV. Bhagwa

Hussain, Sadiq; Reddy, P. Syam Sundar; Reddy, M.L.N.; Murthy, B. N. S.; Upreti, K.K.; Laxman, R. H.

doi:10.21276/ap.2021.10.1.30

Cited by 2 publications

(6 citation statements)

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“…Taking advantage of the high-resolution of our datasets, we sought to map the brain-wide changes in TH+ neuronal projections in response to chronic ketamine (100 mg/kg, 10 days) exposure. TH+ neuronal projections may be dopaminergic or noradrenergic, but they can only be inferred as catecholaminergic 28 , 29 in this study. We used the suiteWB pipeline to estimate the TH+ neuronal projection densities in the ketamine-treated and saline control whole-brain datasets and performed voxel-by-voxel (at 25 × 25 × 25 μm 3 sampling) statistical comparisons between the groups.…”

Section: Resultsmentioning

confidence: 78%

“…Notably, although DA can be further converted to other catecholamines (norepinephrine and/or epinephrine) in downstream pathways, the distribution of these noradrenergic neurons is known to be localized within the hindbrain regions (pons and medulla). 28 , 29 Nevertheless, due to their brain-wide projections (e.g., to cerebral cortex, hippocampus, amygdala, and hypothalamus), the precise identity of the TH+ neuronal projections (as DA or noradrenergic) in our datasets may only be inferred as catecholaminergic. 28 , 29 …”

Section: Resultsmentioning

confidence: 99%

“… 28 , 29 Nevertheless, due to their brain-wide projections (e.g., to cerebral cortex, hippocampus, amygdala, and hypothalamus), the precise identity of the TH+ neuronal projections (as DA or noradrenergic) in our datasets may only be inferred as catecholaminergic. 28 , 29 …”

Section: Resultsmentioning

confidence: 99%

“…Note that, although DA may further get processed in the noradrenergic neurons, the distribution of these neurons is well known to be restricted to specific domains in hindbrain regions. 28 , 29 However, the TH+ neuronal projections may still only be precisely identified as DA or noradrenergic by TH immunolabeling. 28 , 29 In addition, the loss of TH protein in DA neurons may not result in a permanent loss of DA neurons; nevertheless, it does indicate the loss of DA-producing capacity due to the required role of TH in the L-DOPA (DA precursor) biosynthesis.…”

Section: Discussionmentioning

confidence: 99%

“… 28 , 29 However, the TH+ neuronal projections may still only be precisely identified as DA or noradrenergic by TH immunolabeling. 28 , 29 In addition, the loss of TH protein in DA neurons may not result in a permanent loss of DA neurons; nevertheless, it does indicate the loss of DA-producing capacity due to the required role of TH in the L-DOPA (DA precursor) biosynthesis.…”

Section: Discussionmentioning

confidence: 99%

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Whole-brain mapping reveals the divergent impact of ketamine on the dopamine system

Datta,

Chen,

Chauhan

et al. 2023

Cell Reports

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Section: Resultsmentioning

confidence: 78%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Whole-brain mapping reveals the divergent impact of ketamine on the dopamine system

Datta,

Chen,

Chauhan

et al. 2023

Cell Reports

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Potential drug-drug interactions with phentermine among long-term phentermine consumers: A retrospective analysis

Fourie,

Julyan,

Mostert

et al. 2023

S Afr Med J

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Background. Phentermine is an internationally recognised amphetamine derivative with significant appetite-suppressing properties. The drug is indicated for the short-term management of obesity, as the long-term (LT) use of phentermine may potentially be associated with severe cardiovascular side-effects, abuse and dependence. The LT use hereinafter describes periods exceeding 12 consecutive weeks. This use may also be associated with potential drug-drug interactions (PDDIs), which may result in adverse drug reactions (ADRs). The literature reports that phentermine is often prescribed LT and for several other off-label indications, increasing the risk for individuals to experience adverse drug events (ADEs) and drug-drug interactions (DDIs). There are, to our knowledge, no South African (SA) studies investigating the prevalence of co-prescribing LT phentermine with drugs that may potentially cause DDIs. Objective. To determine the prevalence of mild, moderate and severe DDIs with phentermine use when the duration of therapy in private healthcare exceeded 12 consecutive weeks. Methods. A cross-sectional drug utilisation review (DUR) was done by using data obtained from a SA pharmacy benefit management (PBM) company’s database. Retrospective data of medicine claims for phentermine, from 1 January 2015 to 31 December 2019, were extracted for analysis. The number of days phentermine was supplied was used to identify the study population, in other words, those patients who received the drug LT. A drug interaction checker (Drugs.com) was used to identify potential mild, moderate and severe DDIs when using phentermine and co-prescribed drugs concurrently. Results. A total of 889 patients received phentermine LT. The top 20 drugs identified as being frequently co-prescribed in this study population demonstrated no mild PDDI, 15 (75%) moderate PDDIs and 5 (25%) severe PDDIs. The most common co-prescribed drug in the moderate group was dextromethorphan (n=282, 31.72%) and the least co-prescribed was formoterol (n=52, 5.85%). Among the drug group ‘severe PDDIs’, tramadol (n=416, 46.79%) was most frequently prescribed, whereas phenylpropanolamine (n=69, 7.76%) was the least prescribed to patients in this group. Conclusion. There are patients who receive LT phentermine therapy despite the potential severe consequences that may result. These patients may receive concomitant therapy with phentermine and other pharmaceutical constituents, which may potentially cause DDIs, more specifically, moderate and severe DDIs. As such, these patients are not only confronted with the consequences of DDIs but are also at risk to experience ADRs as the residual effect of PDDIs.

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Studies on flower induction and improvement of fruit yield and its attributes in pomegranate (Punica granatum L.) CV. Bhagwa

Cited by 2 publications

References 0 publications

Whole-brain mapping reveals the divergent impact of ketamine on the dopamine system

Whole-brain mapping reveals the divergent impact of ketamine on the dopamine system

Potential drug-drug interactions with phentermine among long-term phentermine consumers: A retrospective analysis

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