Studies on Fragrance Delivery from Inorganic Nanocontainers: Encapsulation, Release and Modeling Studies

Abstract

The present work deals with encapsulation of fragrance molecule in inorganic nanocontainers substrate and investigation of its prolonged release at different pH condition. The nanocontainers used were aluminosilicate clay (Halloysite) having cylindrical shape with outside diameter in the range of 30-50 nm, 15 nm lumen and length equal to 800 ± 300 nm. Rosewater absolute was used as a sample fragrance for loading in nanocontainer and delivery purpose. The fragrance loaded nanocontainers were coated with a thin layer of polyelectrolyte i.e. Polyacrylic Acid (PAA). The structural characteristics of prepared nanocontainers were determined by using Fourier Transform Intrared Spectroscopy (FTIR), Thermal Gravimetric Analysis (TGA) and UV spectroscopy analysis. Release of fragrance molecules in the aqueous medium was monitored for 24 h. The fragrance release was found to be responsive as the amount of fragrance release increases with increase in pH value from 3 to 7. Fragrance release has been studied by using various permeation kinetic models such as zero order, first order, Hixson-Crowell, Higuchi, Korsmeyer-Peppas and Hopfenberg models. Korsemyer-Peppas shows the best fit (R 2 = 0.9544) compared to other kinetic model for the release of fragrance from nanocontainers.

Halloysite nanotubes as a new drug-delivery system: a review

“…These active agents can be used to improve skin elasticity, skin moisture and to maintain skin softness, smoothness, shininess and firmness, to treat wrinkles and age spots and to discontinue the signs of ageing. In addition to these active ingredients, any other active materials which improve or treat skin conditions can be loaded into halloysite nanotubes for use in cosmetic treatments (Suh et al, 2011;Ghodke et al, 2015). In its tubular shape, halloysite causes irritation to the skin.…”

Controlled Thermal Release of L-Menthol with Cellulose-Acetate-Fiber-Shelled Metal-Organic Framework

“…In recent years, adsorption technology is favored for practical applications because of its low cost and facile implementation process. In the adsorption-based encapsulation process, the fragrance is adsorbed into porous hosts such as zeolite [9], activated carbon [10], silica nanoparticles [11], silicoaluminate [12] and calcium carbonate [13]. Despite the fact that porous host materials could prolong the release period of the fragrance to some extent, most host materials are susceptible to environmental interference or even degradation during the fragrance adsorption process [8].…”

Adsorption and controlled release of three kinds of flavors on UiO‐66

“…Currently, the delivery system has been widely employed to capture these volatile molecules and achieve controlled release of fragrances (Liu, Chen, Fishman, & Hicks, ). Porous materials (Kaura, Kukkar, Bhardwaj, Kim, & Deep, ) such as zeolites (Tekin & Bac, ), silica nanoparticles (Hu, Liu, Xie, & Wu, ), activated carbon (Fernandez‐Perez, Villafranca‐Sanchez, Flores‐Cespedes, Garrido‐Herrera, & Perez‐Garcia, ), aluminosilicate (Ghodke, Sonawane, Bhanvase, Mishra, & Joshi, ), and calcium carbonate (Levy et al, ) have been used extensively as supporters or carriers for the delivery release of various kinds of fragrances. They exhibit well storage and release capacity which depends upon the properties of pore structure, molecular structure, and the interaction of fragrance molecules with porous materials (Ganicz, Kurjata, Perry, & Stanczyk, ; Ghayempour & Montazer, ).…”

“…They exhibit well storage and release capacity which depends upon the properties of pore structure, molecular structure, and the interaction of fragrance molecules with porous materials (Ganicz, Kurjata, Perry, & Stanczyk, ; Ghayempour & Montazer, ). However, most delivery systems always suffer from the problems such as early evaporation and degradation of flavors on scaffold materials during adsorption process (Madene, Jacquot, Scher, & Desobry, ), vulnerable to external factors (temperature, humidity, or chemical interactions; Cao et al, ; Ghodke et al, ), or supporters with strong adsorption capacity but weak desorption (Ciriminna & Pagliaro, ), or vice versa.…”