STUDIES ON GASTROINTESTINAL EFFECTS OF &lt;i&gt;DESMODIUM VELUTINUM&lt;/i&gt;: A TRADITIONAL REMEDY FOR DIARRHEA

Ezike, Adaobi Chioma; Akah, Peter A.; Okoli, C. O.; Ufere, Ifechukwu Kenneth; Ezeudu, E.; Okoye, Charles Obinwanne; Ashara, C.; Igbokwe, I. N.

doi:10.3844/ajptsp.2014.114.124

Cited by 12 publications

(16 citation statements)

References 19 publications

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“…where the result of LD50 was greater than 3000 mg/kg showing that D. velutinum extract is relatively safe for human consumption. This is however contrary to the reports of [15,16] where the oral administration of methanol extract of Desmodium velutinum leaves produced no physical signs of toxicity such as weakness, writhing, gasping, palpitation, anorexia, reduction in body weight, decreased respiratory rate or death up to the highest administered oral dose (5000 mg/kg body weight) within 24 h of post: administration. The oral LD 50 of DVE in mice was thus established to be greater than 5000 mg/kg.…”

Section: Discussioncontrasting

confidence: 97%

Methanol Leaf Extract of Desmodium velutinum (Wild.) D.C. and Acarbose Exhibit Additive Pharmacological Effects in Diabetic Wistar Rats

Idakwoji

2021

AJBSR

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This study investigated the pharmacological effects of methanol extract of Desmodium velutinum leaves (DVE) administered alone and when co-administered with Acarbose (ACA) in diabetic Wistar rats. Preliminary phytochemical analysis and acute toxicity study were carried out on DVE using standard methods. In the pharmacological study, diabetes was induced in rats by intraperitoneal administration of 150 mg alloxan/kg b.w. Seven groups (6 groups of diabetic rats and 1 group of normoglycemic rats) of four rats each were used for the study. Groups I and II served as normoglycemic (NDC) and diabetic controls (DC) respectively and received 1ml distilled water/kg b.w. Groups III and IV were administered 400 and 800 mg DVE/kg respectively while groups V and VI were administered the same doses (400 and 800 mg/kg respectively) but co-administered with a fixed dose of ACA (150 mg/kg b.w.). Group VII was administered 150 mg ACA/ kg b.w. alone. Weekly fasting blood sugar (FBS) levels and body weight changes were estimated for 28 days. After the 28-day treatment regimen, rats were euthanized, and blood samples collected for serum biochemical analysis. Phytochemical analysis of DVE revealed the presence of alkaloids, phenols, flavonoids, tannins, steroids and terpenoids in varying proportions. Treatment with DVE alone and its co-administration with ACA significantly (p< 0.05) reduced FBS and serum biochemicals parameters of rats compared with diabetic control. DVE alone and its co-administration with ACA also significantly (p< 0.05) increased the serum total protein of rats compared with diabetic control. However, the pharmacological effects of DVE and ACA co-administration were significantly (p< 0.05) higher than that of DVE or ACA administered alone. It was concluded that DVE and ACA exhibited additive pharmacological effects in diabetic Wistar rats and as such could be useful in the management of diabetes.

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Section: Discussioncontrasting

confidence: 97%

Methanol Leaf Extract of Desmodium velutinum (Wild.) D.C. and Acarbose Exhibit Additive Pharmacological Effects in Diabetic Wistar Rats

Idakwoji

2021

AJBSR

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“…It was found that administration of the methanol leaves extract of Desmodium velutinum alone resulted in approximately 72% inhibition of ulceration and this finding is in agreement with a similar study that reported the gastroprotective effect of leaves to extract of Desmodium velutinum against an ethanol-induced ulcer in experimental rats [25]. However, in this study, the concept of combination therapy of natural flora is introduced for the treatment of peptic ulcers which is evidently reported by [11,33] to be an effective treatment strategy.…”

Section: Discussionsupporting

confidence: 90%

“…Although it has been reported that dose-dependent crude leaves extract of Desmodium velutinum showed gastro protection against experimentally induced ulcers in Wistar rats using ethanol [25], this is the first report on the gastroprotective effects of a combination of crude methanol leaf extract of Desmodium velutinum and honey on ethanolinduced gastric ulcer in albino rat models. This study evaluated the acute toxicity, gastrotherapeutic and gastroprotective effect of crude methanol leaf extract of Desmodium velutinum combined with honey in rats.…”

Section: Introductionmentioning

confidence: 75%

Gastroprotective effects of Methanol leaf extract of Desmodium velutinum (Fabaceae) and honey on ethanol-induced gastric ulcer in albino rat: The concept of combination therapy

Onyeka¹,

Onyegbule²,

Ezugwu³

et al. 2022

GSC Biol. Pharm. Sci.

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Phytochemicals are known for their therapeutic effects through diverse mechanisms such as therapeutic modulators, substrate ligands, receptor ligands, enzyme cofactors, enzymes precursors, toxins scavengers, microbial growth inhibitors, therapeutic agents, and therapeutic enhancers in the treatment of various diseases and ailments. Folklorically, the indigenous people of Nigeria have used Desmodium velutinum (Fabaceae) for treatment of disease conditions such as headache, fever, diarrhea toothaches, ulcers, anti-oxidants, and pains. This study investigated the toxicity, and anti-ulcer effects of a combination of methanol leaf extract of Desmodium velutinum and honey in rats. Anti-ulcer studies were carried out using absolute ethanol rat models of ulceration. The rats were distributed into ten groups of five rats each. Group 1 served as a negative control, group 2 served as a positive control, group 3 served as untreated control, the test groups: groups 4 to 6 received crude extract of Desmodium velutinum at doses of 100, 250, and 500 mg/kg respectively, groups 7 to 9 received a combination of 1 ml honey and crude leaf extract of Desmodium velutinum at doses of 100, 250 and 500 mg/kg while group 10 received 1 ml of honey only. The acute toxicity showed that the extract caused no death in the mice at 5000mg/kg and therefore the LD50 is above 5000mg/kg. The result also showed that 500 mg/kg of the crude extract and 1 ml honey had 42.9% and 71.76 % inhibition of ulceration respectively, while their combination had 100% inhibition of ulceration among the rats treated with the combinations. The combination of methanol leaves extract of Desmodium velutinum and honey exhibited gastrotherapeutic effect in rats and suggest its continued usage as an antiulcer agent for the treatment of ulcer.

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“…Flavonoids such as quercetin have been reported to possess laxative effect by promoting gastrointestinal motility and mucinsecretion. 21 Flavonoids are hydroxylated phenolic substances known for several medicinal importance such as antioxidant, antiulcer, among others. [22][23][24] Tannins are astringent bitter compound found in a variety of plant that binds and precipitate proteins and other organic compounds including amino acids and alkaloids.…”

Section: Phytochemical Evaluation Of the Plant Fractionmentioning

confidence: 99%

Ameliorative Effects of Ethyl acetate Fraction of Millettia aboensis Stem Bark on Loperamide-Induced Constipation in Rats

2020

TJNPR

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Constipation (dyschezia) is a gastrointestinal disorder characterized by infrequent bowel movements, causing the stool to become hard and dry, and leading to difficulties during defecation, as well as a sensation of incomplete bowel evacuation. 1,2 This occurs when the colon absorbs too much fluid than required as a result of the inability to relax the pelvic muscles to allow for a bowel movement (anismus) or the inability of the pelvic muscles to effectively and correctly coordinate relaxation and contraction (dyssynergia). It could also result from disease conditions or life style. 3,4 Apart from difficulties and pains experienced during bowel movement, other symptoms of constipation include feeling bloated, uncomfortable, and sluggishness. 2,5 However, medicinal plants are the richest source of medicines to humanity. 1 Prehistoric people, especially Africans relied on the healing properties of medicinal plants before the introduction of orthodox medicines. 6 The therapeutic efficiency of these medicinal plants can justifiably be attributed to the phytochemicals in them such as the flavonoids, alkaloids, sterols, terpenoids, phenolic acids, stilbenes, lignans, tannins and saponins, etc. 7 Phytochemicals are known to activate, catalyse and initiate some curative reactions in humans. 8-11 It is also believed that the various phytochemicals could work synergistically to exert their therapeutic effect. 7,11-12 Milletiaaboensis is one of the plants that have been reported to

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STUDIES ON GASTROINTESTINAL EFFECTS OF <i>DESMODIUM VELUTINUM</i>: A TRADITIONAL REMEDY FOR DIARRHEA

Cited by 12 publications

References 19 publications

Methanol Leaf Extract of Desmodium velutinum (Wild.) D.C. and Acarbose Exhibit Additive Pharmacological Effects in Diabetic Wistar Rats

Methanol Leaf Extract of Desmodium velutinum (Wild.) D.C. and Acarbose Exhibit Additive Pharmacological Effects in Diabetic Wistar Rats

Gastroprotective effects of Methanol leaf extract of Desmodium velutinum (Fabaceae) and honey on ethanol-induced gastric ulcer in albino rat: The concept of combination therapy

Ameliorative Effects of Ethyl acetate Fraction of Millettia aboensis Stem Bark on Loperamide-Induced Constipation in Rats

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