Studies On Granuloma Inguinale-VII: VII. SOME EPIDEMIOLOGICAL CONSIDERATIONS OF THE DISEASE

Goldberg, Julius

doi:10.1136/sti.40.2.140

Cited by 15 publications

(4 citation statements)

References 7 publications

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“…26 Only in 1943, the 'Donovan bodies' were determined as Klebsiella granulomatis (=Calymmatobacterium granulomatis) (Enterobacteriales: Enterobacteriaceae). 27 The aetiology of donovanosis and its venereal nature were elucidated subsequently. 28 Donovan's discovery of the visceral leishmaniasis-inducing protozoan (later named Leishmania donovani [Trypanosomatidae: Trypanosomatidae]) was made when he was the professor of medicine at MMC, which was the teaching wing of the GH, and conjointly superintending the Royapettah Hospital (Note 5).…”

Section: The General Hospital Of the Presidencymentioning

confidence: 99%

On the quarter-millennial anniversary of the Madras General Hospital

Raman

2022

NMJI

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The General Hospital (GH) of Madras (presently Chennai) grew out of a hospital intended for the personnel attached to the Madras army—a Military Hospital (MH)—established within the Fort St George in 1664. Although the GH grew out of this MH, its relocation at its present Périamét (then known as Narimédu, Hog’s Hill) site in 1772, bearing the name ‘General Hospital’ marks its 250th anniversary in 2022. From being MH that serviced the ‘white’ residents of Madras, it opened to locals in 1899. In 2011, it was renamed as the Rajiv Gandhi Government General Hospital. Today, it has grown into a stunning medical facility in India treating about 12 000 patients a day. We chronicle the growth of the MH into the GH. Notable that the first formally conducted medical forensic examination in the whole of India occurred in this facility in August 1693, when this institution was MH. Surgeon Samuel Browne’s erroneous dispensation of a medication resulted in the death of James Wheeler, a prominent English-East India Company (EEIC) civil servant in Madras. Following an order to execute an investigation by the Governor, Fort St George, an autopsy of the body of Wheeler was carried out by Surgeon Edward Bulkley. Further to referring to such landmark historical details of early time segments of the MH and GH, we briefly refer to the remarkable medical work of Charles Donovan, William Niblock and Mysore Ramaswami Guruswami Mudaliar, who worked at the GH in the early decades of the 20th century.

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Section: The General Hospital Of the Presidencymentioning

confidence: 99%

On the quarter-millennial anniversary of the Madras General Hospital

Raman

2022

NMJI

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“…The causative agent, Calymmatobacterium granulomatis, has been isolated from faeces, and transmission through auto-inoculation is suggested. 2 The organism possesses a capsule and is similar to klebsiella strains but its biochemical and bacterial characteristics are not well defined. 3 Although previously thought to be uncommon in Southern Africa, donovanosis has recently emerged as a significant cause of GUD in Durban.…”

Section: Introductionmentioning

confidence: 99%

HLA antigens in donovanosis (granuloma inguinale).

O’Farrell

Hammond

1991

Sexually Transmitted Infections

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“…Donovanosis was reportedly common in parts of India, where such a practice was prevalent. 6 Among a series of 858 cases from India, primary perianal and anal lesions were found to be four times common in men, resulting mainly from anal sex. 1 The causative organism has been cultured after several years and confirmatory polymerase chain reaction techniques developed using a colorimetric system.…”

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“…8 The normal habitat of the organism could be the intestine, where it causes no problem and may result in lesions as a result of autoinoculation or through vaginal intercourse, if the latter is contaminated with enteric bacteria or through rectal intercourse. 6 As suggested by Goldberg and Bernstein,9 the location of the lesions is such that fecal contamination and trauma could easily occur.…”

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confidence: 99%

Primary perianal perineo‐crural postpederasty donovanosis

Ghorpade¹

2007

Int J Dermatology

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A 15-year-old boy presented with perianal skin lesion of duration 9 months. It had started as a small nodule in the perianal area, which gradually ulcerated and spread to involve the perineum and both the crural folds. He had taken some herbal medicines orally (nature unknown) from a quack without any relief and came to hospital only after the lesion became extensive, painful, and caused difficulty in defecation. Anal sex was forced on him repeatedly over 6-8 months before onset of lesion by two adult pederasts. He was illiterate and belonged to a poor socioeconomic group. There was no history of heterosexual contact, drug addiction, fellatio, and use of condoms.Cutaneous examination showed an extensive, V-shaped, deep, perianal, erythematous, necrotic ulcer with a granulomatous base and raised edges extending over the perineum and both the crural folds measuring about 20 cm in length and 12 cm in breadth at its longest and broadest points. It was soft and tender. The ulcerative band in the crural region had whitish edges and it was longer on the right side (Fig. 1). Fecal matter was seen projecting from the granulomatous ulcer in the perineal region. There was no penile ulcer, lymphadenopathy, or positive systemic finding. Active agents were untraceable for examination. The dark ground examination for Treponema pallidum and the blood venereal disease research laboratory tests were negative, whereas enzyme-linked immunosorbent assay for HIV 1 was positive. Routine hematological investigations were normal. Crushed tissue smear examination stained with Giemsa revealed intracytoplasmic Donovan bodies inside the monocytes, confirming the diagnosis of donovanosis (Fig. 2). An appreciable response was seen after oral norfloxacin 400 mg given twice daily for 28 days. He was also advised to get his baseline CD 4 count for starting and monitoring antiretroviral treatment, but did not get it done and was subsequently lost to follow up. Figure 1 Extensive, necrotic, granulomatous crural and perianal lesion

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Studies On Granuloma Inguinale-VII: VII. SOME EPIDEMIOLOGICAL CONSIDERATIONS OF THE DISEASE

Cited by 15 publications

References 7 publications

On the quarter-millennial anniversary of the Madras General Hospital

On the quarter-millennial anniversary of the Madras General Hospital

HLA antigens in donovanosis (granuloma inguinale).

Primary perianal perineo‐crural postpederasty donovanosis

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