Studies on Hanganutziu-Deicher Antigens-Antibodies

Abstract

Sera of patients with various liver diseases were examined for the presence of Hanganutziu-Deicher (H-D) antibodies by enzyme immunoassay with high-molecular weight glycoprotein (HMWGP) isolated from bovine red blood cell stromata. IgG class H-D antibodies were demonstrated in sera of 5.9% of acute hepatitis, 28.1 % of chronic hepatitis and 21.9% of liver cirrhosis patients. H-D specificity of the antibodies under investigation was determined by absorption experiments. Evidence was also presented that the H-D antibodies in the liver disease sera are directed to N-glycolyl neuraminic acid (NGNA) and/or NGNA-dependent determinants of HMWGP.

Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid

“…While this article was in preparation, another group independently reported a high prevalence of anti-Neu5Gc antibodies in normal human sera, using a different approach (39). The findings of both studies stand in contrast to previous reports of the prevalence of anti-Neu5Gc antibodies in normal humans, ranging only from 0-10% for the IgG class to 3.8-13.8% for the IgM class (40)(41)(42). This disparity can be explained by the greater sensitivity and lower background of the assays we used, the use of an optimal control target (identical except for Neu5Ac in place of Neu5Gc), and the checks for specificity (blockade by chimpanzee but not human serum, or by free Neu5Gc but not free Neu5Ac).…”

“…Some other diseases such as hepatitis, liver cirrhosis, infectious mononucleosis, rheumatoid arthritis, syphilis, and lepromatous leprosy are claimed to be associated with ''Hanganutziu-Deicher'' heterophile anti-Neu5Gc antibodies (40)(41)(42). Such antibodies could play a role in initiation or progression or simply arise from immune dysregulation that allows preexisting memory B cells to expand.…”

Comparison of Milk Oligosaccharides Pattern in Colostrum of Different Horse Breeds

“…For example, such oligosaccharides account for about 6% of the oligosaccharides in cows’ colostrum . On the contrary, milk oligosaccharides decorated with Neu5Gc are absent in human colostrum, which is considered as beneficial because blood antibodies against Neu5Gc are present in several diseases such as acute and chronic hepatitis, hyperacute transplant rejection, and cancer. ,− …”