Studies on High Molecular Weight Aliphatic Amines and their Salts. VII. The Systems Octylamine—, Dodecylamine— and Octadecylamine—Water

Ralston, A. W.; Hoerr, C. W.; Hoffman, Everett J.

doi:10.1021/ja01259a009

Cited by 45 publications

(26 citation statements)

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“…This result indicated that the ionic complex played an irreplaceable role in breviscapine encapsulation. The resultant nanoparticles had a positive zeta potential (19.8 mV), which could be attributed to the octadecylamine with an added ammonium group [35] . It has been demonstrated that nanoparticles with a positive charge are [36] .…”

Section: Discussionmentioning

confidence: 99%

Development of ionic-complex-based nanostructured lipid carriers to improve the pharmacokinetic profiles of breviscapine

Zheng

Shan

et al. 2013

Acta Pharmacol Sin

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Aim: Breviscapine isolated from the Chinese herb Erigeron breviscapus (Vant) Hand-Mazz is widely used to treat cardiovascular and cerebrovascular diseases. The aim of this study was to improve the pharmacokinetic profiles of breviscapine using nanostructured lipid carrier based on an ionic complex formation. Methods: Breviscapine nanostructured lipid carrier (Bre-NLC) was prepared using the thin film homogenization method. The morphology of Bre-NLCs was determined using transmission electron microscopy. The mean particle size, polydispersity index, zeta-potential analysis and entrapment efficiency were analized. In vitro release was studied using the dialysis method. In vitro stability was studied in fresh plasma and liver slurry of rats. In vivo pharmacokinetics was analyzed in rats after intravenous injection of a dose equivalent to breviscapine (10 mg/kg). Results: The Bre-NLCs were spherical with a mean particle size of ~170 nm, a zeta potential of ~20 mV and a high entrapment efficiency of ~89%. Compared with a commercially available solution, a substantial decrease in the cumulative release of breviscapine was found for the Bre-NLCs. The NLC has a significantly protective effect against the liver enzyme degradation of breviscapine. After intravenous administration in rats, the Bre-NLCs exhibited a 32 times increase in the AUC 0-t and a 12 times increase in T 1/2 as compared to the commercially available breviscapine solution. Conclusion:The results demonstrate that the NLC has great potential to use as a novel sustained release system for breviscapine.

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Section: Discussionmentioning

confidence: 99%

Development of ionic-complex-based nanostructured lipid carriers to improve the pharmacokinetic profiles of breviscapine

Zheng

Shan

et al. 2013

Acta Pharmacol Sin

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“…The approximations made in Eqs. [4] and [5] underestimate the counter-ion binding at the lower mass fractions. In Figs.…”

Section: Solution Phase Lmentioning

confidence: 93%

Self-Assembly in the System Decanoic Acid–Butylamine–Water

Karlsson

Friman

Lindström

et al. 2001

Journal of Colloid and Interface Science

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“…Analogy to the monolayer-confined synthesis, octylamine/water bilayer systems was employed by Adair et al (1998) to grow a number of nanoscale platelets including CdS, (Adair and Suvaci, 2000;Adair et al, 1998) Ag (Yener et al, 2002) and SiO 2 (Wang et al, 2006) at ambient condition. When mixed with water under appropriate weight ratio, the amines will orient in such a way that allows organic layer and aqueous layer to alternate in the solution, mainly because of the amphiphilic nature of the organic molecules (Adair et al, 1998;Ralston et al, 1942). The thickness of each layer is directly related to the amine to water weight ratio, which provides an effective pathway to manipulate the template thereby the nanoparticle thickness during synthesis.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Calcium Carbonate Particles in Octylamine/Water Bilayer Systems

Wang

White

Adair

2014

KONA

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Calcium carbonate particles with various shapes and morphologies were prepared via precipitation in an octylamine/water self-assembly bilayer systems. Crystal structure and shape of the CaCO 3 particles were determined by the water to octylamine molar ratio R of the bilayer. At R = 16.0, phase pure calcite particles with a "hopper crystal" morphology were formed, the average particle size of the hopper crystal is 10 μm with welldefined edges on the hopper faces. Decrease the R ratio to 7.2 eventually leads to the formation of 3 μm tabular CaCO 3 particles which are predominated by vaterite structure. For an intermediate R of 10.8, spherical vaterite aggregates and rhombohedral calcite particles were produced. Thermal decomposition of the CaCO 3 particles was observed at around 710°C. The mechanism of particle evolution in the self-assembly bilayer, particularly the formation of "hopper crystal" calcite was discussed.

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Studies on High Molecular Weight Aliphatic Amines and their Salts. VII. The Systems Octylamine—, Dodecylamine— and Octadecylamine—Water

Cited by 45 publications

References 0 publications

Development of ionic-complex-based nanostructured lipid carriers to improve the pharmacokinetic profiles of breviscapine

Development of ionic-complex-based nanostructured lipid carriers to improve the pharmacokinetic profiles of breviscapine

Self-Assembly in the System Decanoic Acid–Butylamine–Water

Synthesis of Calcium Carbonate Particles in Octylamine/Water Bilayer Systems

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