Studies on Human Pharmaceuticals in Jordanian Wastewater Samples

Al-Tarawneh, Ibrahim; El-Dosoky, M.F.; Alawi, Mahmoud A.; Batarseh, Mufeed; Widyasari, Arum; Kreuzig, Robert; Bahadir, Müfit

doi:10.1002/clen.201300920

Cited by 11 publications

(14 citation statements)

References 41 publications

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“…This value is also in agreement with the concentration reported by Al-Tarawneh et al i.e. 3600 ng/L in Jordan [106]. Lower concentrations of CBZ (< 200 ng/L) in STP influents have been reported in Japan (137 ng/L) [52], Greece (114 ng/L) [104] and Vietnam (190 ng/) [93].…”

Section: Anti-convulsantsupporting

confidence: 91%

Occurrence and Distribution of 17 Targeted Human Pharmaceuticals in Various Aquatic Environmental Matrices in Southeast Asia with Particular Reference to Malaysia: A Comprehensive Review

et al. 2021

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Abstract. This review focuses on the occurrence and distribution of 17 targeted human pharmaceutical compounds from the most common therapeutic classes. These include one analgesic (acetaminophen), three non-steroidal anti-inflammatory drugs (NSAIDs) (acetylsalicylic acid, diclofenac, ibuprofen), two antidiabetic drugs (gliclazide, metformin), three antihistamines (cetirizine, chlorphenamine, ranitidine), four antihypertensives (amlodipine, atenolol, metoprolol, prazosin), one lipid regulator (simvastatin), one anti-convulsant (carbamazepine), one bronchodilator agent (salbutamol) and one stimulant (caffeine) which have been detected globally in various aquatic environmental matrices such as surface water, drinking water, ground water, seawater, influent and effluent of municipal wastewater treatment plants (WWTPs), hospital and industrial treatment plants, among others. The most common analytical method used involved solid phase extraction (SPE) and liquid chromatography coupled to mass spectrometry. The concentrations of all drugs investigated in all aqueous matrices varied from 0.5 to 85,000 ng/L for the highest concentration in the aqueous matrices in Southeast Asia. This review provides the first compilation on human pharmaceuticals in Southeast Asia in surface water, domestic wastewater (influent and effluent) and drinking water. Resumen. Esta revisión se centró en la aparición y distribución de 17 fármacos de uso humano pertenecientes a las clases terapéuticas más comunes y consiste en un analgésico (acetaminofeno), tres medicamentos antiinflamatorios no esteroideos (AINE) (ácido acetilsalicílico, diclofenaco, ibuprofeno), dos antidiabéticos (gliclazida, metformina), tres antihistamínicos (cetirizina, clorfenamina, ranitidina), cuatro antihipertensivos ( atenolol, metoprolol, prazosina), un regulador de lípidos (simvastatina), un anticonvulsivo (carbamazepina), un agente broncodilatador (salbutamol) y un estimulante (cafeína), y que se han detectado globalmente en varios tipos de matrices ambientales acuáticas como el agua superficial, agua potable, agua subterránea, agua de mar, afluente y efluente de plantas de tratamiento de aguas residuales municipales (EDAR), plantas de tratamiento hospitalarias e industriales entre otras. El método analítico más utilizado involucró extracción en fase sólida (SPE) y cromatografía líquida acoplada a espectrometría de masas. Las concentraciones de todos los fármacos investigados en todas las matrices acuosas variaron de 0,5 a 85.000 ng / L, y presentaron la concentración más alta en las matrices acuosas en el país del sudeste asiático. Esta revisión proporciona el primer informe recopilatorio sobre un estudio de productos farmacéuticos humanos que se ha realizado en el sudeste asiático y se centra en aguas superficiales, aguas residuales domésticas (afluentes y efluentes) y agua potable.

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Section: Anti-convulsantsupporting

confidence: 91%

Occurrence and Distribution of 17 Targeted Human Pharmaceuticals in Various Aquatic Environmental Matrices in Southeast Asia with Particular Reference to Malaysia: A Comprehensive Review

et al. 2021

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“…This condition would partly explain the increase in antibiotic concentrations in effluent compared with influent, as also suggested in other studies [45,46]. Another explanation could be the presence of antibiotic conjugates or metabolites, which were cleaved back to their mother forms during the treatment process [46,47].…”

Section: Concentration and Removal Of Phacs And Antibiotics In Assamra Wwtpsupporting

confidence: 53%

Pharmaceutical and Antibiotic Pollutant Levels in Wastewater and the Waters of the Zarqa River, Jordan

et al. 2021

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Assamra wastewater treatment plant (WWTP) is the largest treatment facility in Jordan. Treated wastewater is discharged into the Zarqa River (ZR) and used to irrigate fodder and vegetables. ZR also includes surface runoff, stormwater, and raw wastewater illegally discharged into the river. This study examined pharmaceutically active compounds (PhAC) in water resources in the ZR basin. Samples of WWTP influent and effluent and river water from four sites along ZR were collected. Concentrations of 18 target antibiotics, one stimulant, and 15 other PhACs were determined in the samples. Five antibiotics were detected in WWTP influent (510–860 ng L−1 for ∑Antibiotics) and six in the effluent (2300–2600 ng L−1 for ∑Antibiotics). Concentrations in the effluent of all antibiotics except clarithromycin increased by 2- to 5-fold compared with those in influent, while clarithromycin concentration decreased by around 4- fold (from 308 to 82 ng L−1). WWTP influent and effluent samples contained 14 non-antibiotic PhACs, one simulant, and six antibiotics at detectable concentrations. The dominant PhACs were paracetamol (74% of ∑PhACs) in the influent and carbamazepine (78% of ∑PhACs) in the effluent. At ZR sampling sites, carbamazepine was the dominant PhAC in all cases (800–2700 ng L−1). The antibiotics detected in WWTP effluent were also detected at the ZR sites. In summary, water in ZR is contaminated with PhACs, including antibiotics, and wastewater discharge seems to be the main pathway for this contamination. The occurrence of antibiotics and other PhACs in the irrigated soil requires investigation to assess their fate.

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“…This was observed in seven WWTPs in Tunisia, where removal efficiencies were −40% in six plants that utilized AS process and −78% in the seventh WWTP which deployed AS/AL (Moslah et al 2017 ). Negative removal (−43%) was also observed in the Al-Salt WWTP in Jordan which used RBC with extended aeration as treatment processes (Al-Tarawneh et al 2014 ). Low removal of carbamazepine was also observed in different WWTPs in Jordan; in the old As-Samra WWTP (0% with AS/WSP), the new As-Samra WWTP (22.5% with AS/extended aeration), Abu-Nsair WWTP (27% with RBC/extended aeration), and Al-Aqaba WWTP (33% with AS/WSP) (Al-Tarawneh et al 2014 ; Al-Mashaqbeh et al 2019b ).…”

Section: Resultsmentioning

confidence: 92%

“…Eight pharmaceutical compounds were among the 20 most frequently studied EPs in raw wastewater. Of these, the highest concentrations were observed for clavulanic acid (26,620–51,460 ng/L), diclofenac (800–35,333 ng/L), ibuprofen (700–34,000 ng/L), carbamazepine (73–3600 ng/L), erythromycin (1.5–3010 ng/L), atenolol (62–2198 ng/L), and sulfamethoxazole (12.1–900 ng/L) (Alahmad and Alawi 2010 ; Gasser et al 2010 ; Al-Tarawneh et al 2014 ; Al Qarni et al 2016 ; Fries et al 2016 ; Moslah et al 2017 ; Al-Mashaqbeh et al 2018 ; Al-Mashaqbeh et al 2019b ; Al-Maadheed et al 2019 ; Craddock et al 2020 ).…”

Section: Resultsmentioning

confidence: 98%

“…Pharmaceuticals were also detected in TWW, with carbamazepine (concentration range 41–17,000 ng/L), atenolol (23.5–2380 ng/L), diclofenac (70–40,000 ng/L), erythromycin (2.4–1187 ng/L), ibuprofen (<10–40,000 ng/L), naproxen(2.94–1300 ng/L), and sulfamethoxazole (5.5–517.5 ng/L) counting as the most-investigated compounds in the MENA region (Avisar et al 2009 ; Alahmad and Alawi, 2010 ; Alidina et al 2014 ; Malchi et al 2014 ; Al-Tarawneh et al 2014 ; Zemann et al 2014 ; Zemann et al 2015 ; Al Qarni et al 2016 ; Fries et al 2016 ; Moslah et al 2017 ; Al-Maadheed et al 2019 ; Al-Mashaqbeh et al 2019b ; Khazri et al 2019 ; Picó et al 2019 ; Craddock et al 2020 ). Significantly, TWW in most cases is reused for irrigation (of green areas, farms, trees n public parks, or fields) or groundwater replenishment.…”

Section: Resultsmentioning

confidence: 99%

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A review on occurrence of emerging pollutants in waters of the MENA region

Haddaoui¹,

Mateo-Sagasta

2021

Environ Sci Pollut Res

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Little is known about the occurrence of emerging pollutants (EPs) in waters in the Middle East and North Africa (MENA) region despite the extensive use of low-quality water there. Available data dealing with the sources, occurrence and removal of EPs within the MENA region in different categories of water is collected, presented and analyzed in this literature review. According to the collected database, the occurrence and removal efficiency of EPs in the water matrix in the MENA region is available, respectively, for 13 and six countries of the 18 in total; no available data is registered for the rest. Altogether, 290 EPs have been observed in different water matrices across the MENA countries, stemming mainly from industrial effluents, agricultural practices, and discharge or reuse of treated wastewater (TWW). Pharmaceutical compounds figure among the most frequently reported compounds in wastewater, TWW, surface water, and drinking water. Nevertheless, pesticides are the most frequently detected pollutants in groundwater. Worryingly, 57 cases of EPs have been reported in different fresh and drinking waters, exceeding World Health Organization (WHO) and European Commission (EC) thresholds. Overall, pharmaceuticals, organic compounds, and pesticides are the most concerning EP groups. The review revealed the ineffectiveness of treatment processes used in the region to remove EPs. Negative removals of some EPs such as carbamazepine, erythromycin, and sulfamethoxazole were recorded, suggesting their possible accumulation or release during treatment. This underlines the need to set in place and strengthen control measures, treatment procedures, standards, and policies for such pollutants in the region.

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Studies on Human Pharmaceuticals in Jordanian Wastewater Samples

Cited by 11 publications

References 41 publications

Occurrence and Distribution of 17 Targeted Human Pharmaceuticals in Various Aquatic Environmental Matrices in Southeast Asia with Particular Reference to Malaysia: A Comprehensive Review

Occurrence and Distribution of 17 Targeted Human Pharmaceuticals in Various Aquatic Environmental Matrices in Southeast Asia with Particular Reference to Malaysia: A Comprehensive Review

Pharmaceutical and Antibiotic Pollutant Levels in Wastewater and the Waters of the Zarqa River, Jordan

A review on occurrence of emerging pollutants in waters of the MENA region

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