Studies on hypo-and hypercoagulability II. Coagulation and fibrin analyses in severe infectious and toxic conditions

Kúnz, F; Hörtnagl, Helmut; Kroesen, G.; Schennach, W; Egg, D.; Rumpl, E.; Aschauer, Rudolf; Holzknecht, F

doi:10.1007/bf01631523

Blut

1974

DOI: 10.1007/bf01631523

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Studies on hypo-and hypercoagulability II. Coagulation and fibrin analyses in severe infectious and toxic conditions

F Kúnz

Helmut Hörtnagl

G. Kroesen

et al.

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1976

1992

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Cited by 3 publications

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“…In such diseases, e.g., severe septic conditions 10 and acute respiratory distress," we found a considerably augmented lipid content in thrombi produced from platelet-poor plasma (PPP) and a platelet substitute. In CAD with chronic and more localized thrombus formation, no significant changes were observed 12 with this method.…”

mentioning

confidence: 99%

Increased lipid binding to thrombi in coronary artery disease. Findings in patients without premedication in native (not anticoagulated) test systems.

Kúnz

Pechlaner

Erhart

et al. 1992

Arterioscler Thromb

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Thrombi and clots were produced from native (i.e., not anticoagulated) platelet-rich and platelet-poor plasma from patients with coronary artery disease and control subjects who had not taken any medication known to influence plasma lipids, coagulation, or platelet aggregation. The clotting times were recorded, and the lipid content of clots, thrombi, platelets, plasma, and high density lipoprotein was analyzed. Thrombi produced from native platelet-rich plasma were 46% heavier in coronary artery disease patients and contained about 20% more phospholipids and free cholesterol and about twice the amount of triglycerides and esterifled cholesterol in both absolute and relative amounts with respect to the corresponding lipids of plasma plus platelets. The elevated content of lipids not only increases the size of the thrombi but also changes their quality because of an increased content in plasmatic lipids, as platelets contain only trace amounts of triglycerides and cholesterol esters. In agreement herewith, fibrinogen and maximal amplitude on the thrombelastogram were increased in coronary artery disease patients, whereas the thrombus-forming time and clotting times of platelet-poor and platelet-rich plasma were shortened, indicating accelerated coagulation and activation of platelets. Analysis of these results suggests a disturbed interrelation in coronary artery disease between lipids and hemostasis, in which platelets, high density lipoprotein, and lipoproteins rich in triglycerides and cholesterol esters may play a role.

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mentioning

confidence: 99%

Increased lipid binding to thrombi in coronary artery disease. Findings in patients without premedication in native (not anticoagulated) test systems.

Kúnz

Pechlaner

Erhart

et al. 1992

Arterioscler Thromb

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Increased complexing of plasmatic lipids with fibrins in hyperlipoproteinaemias

et al. 1976

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Clot lipids in ischaemic heart disease

1983

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Studies on hypo-and hypercoagulability II. Coagulation and fibrin analyses in severe infectious and toxic conditions

Cited by 3 publications

References 37 publications

Increased lipid binding to thrombi in coronary artery disease. Findings in patients without premedication in native (not anticoagulated) test systems.

Increased lipid binding to thrombi in coronary artery disease. Findings in patients without premedication in native (not anticoagulated) test systems.

Increased complexing of plasmatic lipids with fibrins in hyperlipoproteinaemias

Clot lipids in ischaemic heart disease

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