2008
DOI: 10.1007/s12034-008-0028-y
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Studies on in vitro release of CPM from semi-interpenetrating polymer network (IPN) composed of chitosan and glutamic acid

Abstract: Interpenetrating polymer network (IPN) beads consisting of chitosan-glutamic acid were prepared for in vitro study of controlled release of chlorpheniramine maleate (CPM). A viscous solution of chitosanglutamic acid was prepared in 2% acetic acid solution, extruded as droplets through a syringe to alkalimethanol solution and the precipitated beads were crosslinked using glutaraldehyde solution. Swelling and drug release studies were carried out. Transport of release medium through the semi-IPN depended upon it… Show more

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Cited by 24 publications
(16 citation statements)
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“…This is almost true for extrusion in long capillaries, but for short capillaries, the entry effect figures prominently and entrance effects are relatively numerous and complicated in short-tube flow of polymer melts [1,3,9,11,28,29]. For the case of a short capillary, Liang [11] obtained some semi-empirical quantitative relationships of the swell ratio with material characteristics and operational parameters [30].…”
Section: Introductionmentioning
confidence: 99%
“…This is almost true for extrusion in long capillaries, but for short capillaries, the entry effect figures prominently and entrance effects are relatively numerous and complicated in short-tube flow of polymer melts [1,3,9,11,28,29]. For the case of a short capillary, Liang [11] obtained some semi-empirical quantitative relationships of the swell ratio with material characteristics and operational parameters [30].…”
Section: Introductionmentioning
confidence: 99%
“…The IPN structure is an entangled network of two or more polymers, where at least one network has been crosslinked in the presence of the other . The IPNs provide synergistic effects by combining the individual properties of the polymers used, resulting in entirely new properties that can be not observed in either of the two individual networks alone.…”
Section: Resultsmentioning
confidence: 99%
“…15 In the present study the kinetic data were analyzed with the help of the following equation, which could be helpful in determining the mechanism of the release process:…”
Section: Release Kineticsmentioning
confidence: 99%