Studies on intracellular transport of secretory proteins in the rat exocrine pancreas

Bieger, Wilfried; Martin-Achard, A; Bassler, Markus; Kern, H.

doi:10.1007/bf00224474

Cited by 61 publications

(3 citation statements)

References 28 publications

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“…At this time food coloured with azocarmine can be seen moving from the foregut into the midgut of the shrimp. Similar time scales for the completion of enzyme production and release have been reported for vertebrates (for references see Bieger et al 1976).…”

Section: The F-(fibrillar) Cellssupporting

confidence: 62%

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Mitotic E- and Secretory F-Cells in the Hepatopancreas of the Shrimp Penaeus Semisulcatus (Crustacea: Decapoda)

Al-Mohanna¹,

Nott²,

Lane³

1985

J. Mar. Biol. Ass.

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INTRODUCTIONIt is apparent, in a review on the decapod hepatopancreas (Gibson & Barker, 1979) that there is some consensus of opinion that the epithelium consists of E-, R-, F- and B-cells and M-cells (Al-Mohanna, Nott & Lane, 1985). Also, it is agreed that the gland produces enzymes and absorbs, digests and stores nutrients and excretes waste material. However, the apportionment of these functions to the different cells and the descriptions of the cytological processes involved are variously explained. Thus, the activity of proteases and amylases has been demonstrated in the secretion produced by the gland but the source of these enzymes is attributed to different cells and various modes of secretion are proposed. Also, no secretion granules of the zymogen type have been seen.There are probably two main reasons for the inconsistent interpretation of the activities of the cells. First, the different stages of the feeding and moult cycles are not taken into account and both these affect the cytology of the gland. Second, some of the functions have been deduced from observations of the fine structure without any experimental treatments to demonstrate more directly the processes involved. In the present work all the animals are taken at the same moult stage and observations are made throughout the feeding cycle. Also, aspects of the function are studied with markers which are administered in the diet and injected into the blood. The activities of hydrolytic enzymes associated with the different epithelial cells have been studied but these will be the subject of a separate publication dealing with the cytochemistry of the digestive processes.

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Section: The F-(fibrillar) Cellssupporting

confidence: 62%

“…In the vertebrates, pancreatic exocrine cells recommence secretory activity after a restitution phase (for references see Bieger et al 1976). In contrast, the F-cells of P. semisulcatus do not have a phase of restitution or renewed synthesis; they do not contain zymogen granules 4, 8, 12 and 24 h after feeding.…”

Section: The F-(fibrillar) Cellsmentioning

confidence: 99%

Mitotic E- and Secretory F-Cells in the Hepatopancreas of the Shrimp Penaeus Semisulcatus (Crustacea: Decapoda)

Al-Mohanna¹,

Nott²,

Lane³

1985

J. Mar. Biol. Ass.

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“…There is a clear dose-response relationship between the structural and biochemical changes of the pancreas in response to caerulein administration (Bieger et al, 1976b). Continuous infusion of maximal physiological doses of caerulein (0.25 µg/kg/h) causes rapid degranulation of the exocrine pancreas in rats (Bieger et al, 1976a). Administration with a supramaximal dose leads to vacuolization within the acinar cells, followed by regeneration of the pancreas (Tardini et al, 1971).…”

Section: Caerulein/cholecystokininmentioning

confidence: 99%

Experimental Acute Pancreatitis Models: History, Current Status, and Role in Translational Research

Yang

Yao

et al. 2020

Front. Physiol.

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Acute pancreatitis is a potentially severe inflammatory disease that may be associated with a substantial morbidity and mortality. Currently there is no specific treatment for the disease, which indicates an ongoing demand for research into its pathogenesis and development of new therapeutic strategies. Due to the unpredictable course of acute pancreatitis and relatively concealed anatomical site in the retro-peritoneum, research on the human pancreas remains challenging. As a result, for over the last 100 years studies on the pathogenesis of this disease have heavily relied on animal models. This review aims to summarize different animal models of acute pancreatitis from the past to present and discuss their main characteristics and applications. It identifies key studies that have enhanced our current understanding of the pathogenesis of acute pancreatitis and highlights the instrumental role of animal models in translational research for developing novel therapies.

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Exocrine Hyperstimulation but Not Pancreatic Duct Obstruction Increases the Susceptibility to Alcohol-Related Pancreatic Injury

Foitzik

Lewandrowski²,

Castillo³

et al. 1994

Arch Surg

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Studies on intracellular transport of secretory proteins in the rat exocrine pancreas

Cited by 61 publications

References 28 publications

Mitotic E- and Secretory F-Cells in the Hepatopancreas of the Shrimp Penaeus Semisulcatus (Crustacea: Decapoda)

Mitotic E- and Secretory F-Cells in the Hepatopancreas of the Shrimp Penaeus Semisulcatus (Crustacea: Decapoda)

Experimental Acute Pancreatitis Models: History, Current Status, and Role in Translational Research

Exocrine Hyperstimulation but Not Pancreatic Duct Obstruction Increases the Susceptibility to Alcohol-Related Pancreatic Injury

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