Studies on intraluminal esophageal manometry for various esophageal disorders.

Lower esophageal sphincter pressure (LESP) was measured before and after endoscopic injection sclerotherapy (EIS) in 41 patients with esophageal varices in order to evaluate the effects of the therapy on the reflux prevention mechanisms. LESP was measured by the infusion method before, upon completion of EIS and 6 months after EIS. The magnitude of the decreases in LESP were significantly greater in patients who had ulcers following EIS than in those who did not. A close correlation was noted between the incidence of clinical symptoms of reflux esophagitis (such as heartburn and retrosternal pain), ulcer formation and decreases in LESP. This finding suggests that ulcer formation by EIS affects the reflux prevention mechanisms of the lower esophageal sphincter. However, disorders of the lower esophageal sphincter seem, transient and also reversible because decreases in LESP recovered and the patients' clinical symptoms improved within 6 months of the EIS.

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Effects of Endoscopic Injection Sclerotherapy for Esophageal Varices on the Reflux Prevention Mechanisms of the Lower Esophageal Sphincter

Suzuki

Fujita

Takahashi

et al. 1991

Digestive Endoscopy

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Studies on intraluminal esophageal manometry for various esophageal disorders.

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Effects of Endoscopic Injection Sclerotherapy for Esophageal Varices on the Reflux Prevention Mechanisms of the Lower Esophageal Sphincter

Effects of Endoscopic Injection Sclerotherapy for Esophageal Varices on the Reflux Prevention Mechanisms of the Lower Esophageal Sphincter

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